Incidental Mutation 'IGL01657:Decr2'
ID103045
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Decr2
Ensembl Gene ENSMUSG00000036775
Gene Name2-4-dienoyl-Coenzyme A reductase 2, peroxisomal
Synonyms
Accession Numbers
Is this an essential gene? Non essential (E-score: 0.000) question?
Stock #IGL01657
Quality Score
Status
Chromosome17
Chromosomal Location26081211-26090329 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to A at 26082952 bp
ZygosityHeterozygous
Amino Acid Change Aspartic acid to Valine at position 268 (D268V)
Ref Sequence ENSEMBL: ENSMUSP00000045621 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000040907]
Predicted Effect probably damaging
Transcript: ENSMUST00000040907
AA Change: D268V

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000045621
Gene: ENSMUSG00000036775
AA Change: D268V

DomainStartEndE-ValueType
Blast:NDK 1 28 5e-9 BLAST
Pfam:adh_short 29 224 3.6e-44 PFAM
Pfam:KR 30 208 3.8e-11 PFAM
Pfam:adh_short_C2 35 271 6.4e-30 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000123056
Predicted Effect noncoding transcript
Transcript: ENSMUST00000134696
Predicted Effect noncoding transcript
Transcript: ENSMUST00000137672
Predicted Effect noncoding transcript
Transcript: ENSMUST00000150534
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 40 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adgrb3 A G 1: 25,826,493 F90L probably benign Het
Anapc4 T A 5: 52,864,626 Y683* probably null Het
Astn2 T G 4: 65,651,949 D773A probably damaging Het
Atp2b3 T C X: 73,545,360 probably benign Het
Atp8b5 T C 4: 43,291,693 M22T probably benign Het
Birc6 T A 17: 74,660,611 L4169H probably damaging Het
Cdc42bpa T C 1: 180,111,866 V81A probably benign Het
Clcn2 A T 16: 20,713,619 C80S probably damaging Het
Clu C T 14: 65,979,672 A318V possibly damaging Het
Csnk1g2 A G 10: 80,639,629 H378R probably benign Het
Dpp3 T C 19: 4,918,304 T247A possibly damaging Het
Eif4g1 A G 16: 20,682,216 N774D possibly damaging Het
Epha4 A T 1: 77,426,838 V344E probably damaging Het
Epha6 A C 16: 59,839,303 N817K probably benign Het
Ggcx T A 6: 72,429,958 probably null Het
Gm1965 C T 6: 89,146,666 noncoding transcript Het
Gmnn T C 13: 24,753,704 E101G probably damaging Het
Grik2 C T 10: 49,527,986 probably null Het
H2-M11 T A 17: 36,547,573 D86E probably benign Het
Il6st T A 13: 112,481,543 W164R probably damaging Het
Ilvbl G T 10: 78,576,768 V108L possibly damaging Het
Klk10 A G 7: 43,781,589 K19E possibly damaging Het
Mbd4 G T 6: 115,849,637 T131N probably damaging Het
Ncapd3 T C 9: 27,071,824 V956A possibly damaging Het
Nif3l1 A C 1: 58,455,612 T247P probably damaging Het
Nrcam T C 12: 44,559,800 V443A probably damaging Het
Olfr1260 A G 2: 89,977,877 Y33C probably damaging Het
Pigk T A 3: 152,722,520 H61Q probably damaging Het
Pla2g4d C A 2: 120,275,287 V431F possibly damaging Het
Pxt1 A T 17: 28,934,804 H18Q possibly damaging Het
Rpusd4 T C 9: 35,273,461 probably benign Het
Slc22a18 T G 7: 143,499,100 L354R probably damaging Het
Slc26a10 A G 10: 127,175,034 V443A probably damaging Het
Smpx A G X: 157,714,680 probably benign Het
Sptan1 A G 2: 30,018,479 S1751G probably benign Het
Ush2a C T 1: 188,826,461 T3629I probably benign Het
Vcan C T 13: 89,690,586 V2280M probably damaging Het
Vmn1r30 T C 6: 58,435,634 E71G probably benign Het
Vmn2r100 A T 17: 19,525,916 I446F possibly damaging Het
Vmn2r75 A T 7: 86,164,247 V449D probably damaging Het
Other mutations in Decr2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02023:Decr2 APN 17 26087380 missense probably benign 0.01
R0003:Decr2 UTSW 17 26083053 missense probably benign 0.00
R0003:Decr2 UTSW 17 26083053 missense probably benign 0.00
R1583:Decr2 UTSW 17 26083024 missense probably damaging 0.99
R1588:Decr2 UTSW 17 26083028 missense possibly damaging 0.91
R1903:Decr2 UTSW 17 26087413 missense probably damaging 0.99
R1968:Decr2 UTSW 17 26083079 missense probably benign 0.00
R2269:Decr2 UTSW 17 26083884 missense probably benign 0.03
R4758:Decr2 UTSW 17 26088940 missense probably damaging 0.96
R5021:Decr2 UTSW 17 26083006 missense probably damaging 1.00
R5174:Decr2 UTSW 17 26087469 splice site probably null
R6608:Decr2 UTSW 17 26083884 missense probably benign 0.30
R6661:Decr2 UTSW 17 26083587 missense possibly damaging 0.53
R8036:Decr2 UTSW 17 26082988 missense probably damaging 0.97
Posted On2014-01-21