Incidental Mutation 'IGL01659:Olfr1049'
ID103103
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr1049
Ensembl Gene ENSMUSG00000075194
Gene Nameolfactory receptor 1049
SynonymsGA_x6K02T2Q125-47735396-47734470, MOR187-1
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.055) question?
Stock #IGL01659
Quality Score
Status
Chromosome2
Chromosomal Location86254357-86258328 bp(-) (GRCm38)
Type of Mutationnonsense
DNA Base Change (assembly) A to T at 86255185 bp
ZygosityHeterozygous
Amino Acid Change Cysteine to Stop codon at position 169 (C169*)
Ref Sequence ENSEMBL: ENSMUSP00000149360 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000099899] [ENSMUST00000216185]
Predicted Effect probably null
Transcript: ENSMUST00000099899
AA Change: C169*
SMART Domains Protein: ENSMUSP00000097483
Gene: ENSMUSG00000075194
AA Change: C169*

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 4.9e-54 PFAM
Pfam:7tm_1 41 290 5.6e-18 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000216185
AA Change: C169*
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 17 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adam32 A T 8: 24,870,774 probably benign Het
Ankrd11 A G 8: 122,895,371 S581P probably damaging Het
Arl13b T C 16: 62,802,750 S370G possibly damaging Het
Cdr2 G T 7: 120,958,549 A251E probably damaging Het
Clec4a4 A T 6: 123,023,935 E202D probably damaging Het
Col14a1 T A 15: 55,446,172 probably benign Het
Dhfr A T 13: 92,355,670 probably null Het
Flnc A G 6: 29,448,671 T1303A probably damaging Het
Mug1 A T 6: 121,870,660 probably benign Het
Napepld A G 5: 21,675,716 V227A probably damaging Het
Nf1 A G 11: 79,559,449 E487G probably benign Het
Nlrp2 A G 7: 5,328,035 L454P probably damaging Het
Rad51 T A 2: 119,118,702 I61K probably benign Het
Rfx8 A T 1: 39,670,573 H431Q probably damaging Het
Sspo A G 6: 48,474,443 N2725S probably damaging Het
Trim16 A G 11: 62,820,695 E64G probably benign Het
Zfp879 T C 11: 50,838,454 Y39C probably damaging Het
Other mutations in Olfr1049
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL03371:Olfr1049 APN 2 86255591 missense possibly damaging 0.88
IGL03378:Olfr1049 APN 2 86255019 missense possibly damaging 0.91
R1529:Olfr1049 UTSW 2 86255241 missense probably damaging 1.00
R1761:Olfr1049 UTSW 2 86255039 missense probably damaging 1.00
R1951:Olfr1049 UTSW 2 86255096 missense probably benign 0.01
R3499:Olfr1049 UTSW 2 86254841 missense possibly damaging 0.91
R3974:Olfr1049 UTSW 2 86255591 missense possibly damaging 0.88
R4094:Olfr1049 UTSW 2 86255330 missense probably damaging 1.00
R4191:Olfr1049 UTSW 2 86255322 missense probably benign 0.03
R4659:Olfr1049 UTSW 2 86255013 nonsense probably null
R6431:Olfr1049 UTSW 2 86255358 missense probably benign 0.01
R7006:Olfr1049 UTSW 2 86255228 missense probably benign 0.01
R7090:Olfr1049 UTSW 2 86255076 missense probably damaging 1.00
Posted On2014-01-21