Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01659:Trim16'

103110

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Trim16

Ensembl Gene

ENSMUSG00000047821

Gene Name

tripartite motif-containing 16

Synonyms

9130006M08Rik, EBBP

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL01659

Quality Score

Status

Chromosome

Chromosomal Location

62711034-62733774 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 62711521 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Glutamic Acid to Glycine at position 64 (E64G)

Ref Sequence

ENSEMBL: ENSMUSP00000055542 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000055006] [ENSMUST00000072639] [ENSMUST00000108703]

AlphaFold

no structure available at present

Predicted Effect

probably benign
Transcript: ENSMUST00000055006
AA Change: E64G

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)

SMART Domains

Protein: ENSMUSP00000055542
Gene: ENSMUSG00000047821
AA Change: E64G

Domain	Start	End	E-Value	Type
Blast:BBOX	64	113	6e-24	BLAST
BBOX	117	157	3.24e-4	SMART
coiled coil region	171	196	N/A	INTRINSIC
coiled coil region	237	265	N/A	INTRINSIC
PRY	364	417	1.41e-22	SMART
SPRY	418	543	6.4e-27	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000072639
AA Change: E64G

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)

SMART Domains

Protein: ENSMUSP00000072432
Gene: ENSMUSG00000047821
AA Change: E64G

Domain	Start	End	E-Value	Type
Blast:BBOX	64	113	5e-24	BLAST
BBOX	117	157	3.24e-4	SMART
coiled coil region	171	196	N/A	INTRINSIC
coiled coil region	237	265	N/A	INTRINSIC
PRY	364	417	1.41e-22	SMART
Pfam:SPRY	418	483	1.4e-6	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000108703

SMART Domains

Protein: ENSMUSP00000104343
Gene: ENSMUSG00000047821

Domain	Start	End	E-Value	Type
Blast:BBOX	1	26	9e-10	BLAST
BBOX	30	70	3.24e-4	SMART
coiled coil region	84	109	N/A	INTRINSIC
coiled coil region	150	178	N/A	INTRINSIC
PRY	277	330	1.41e-22	SMART
SPRY	331	456	6.4e-27	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000147942

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a tripartite motif (TRIM) family member that contains two B box domains and a coiled-coiled region that are characteristic of the B box zinc finger protein family. While it lacks a RING domain found in other TRIM proteins, the encoded protein can homodimerize or heterodimerize with other TRIM proteins and has E3 ubiquitin ligase activity. This gene is also a tumor suppressor and is involved in secretory autophagy. [provided by RefSeq, Jan 2017]

Allele List at MGI

Other mutations in this stock

Total: 17 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adam32	A	T	8: 25,360,790 (GRCm39)		probably benign	Het
Ankrd11	A	G	8: 123,622,110 (GRCm39)	S581P	probably damaging	Het
Arl13b	T	C	16: 62,623,113 (GRCm39)	S370G	possibly damaging	Het
Cdr2	G	T	7: 120,557,772 (GRCm39)	A251E	probably damaging	Het
Clec4a4	A	T	6: 123,000,894 (GRCm39)	E202D	probably damaging	Het
Col14a1	T	A	15: 55,309,568 (GRCm39)		probably benign	Het
Dhfr	A	T	13: 92,492,178 (GRCm39)		probably null	Het
Flnc	A	G	6: 29,448,670 (GRCm39)	T1303A	probably damaging	Het
Mug1	A	T	6: 121,847,619 (GRCm39)		probably benign	Het
Napepld	A	G	5: 21,880,714 (GRCm39)	V227A	probably damaging	Het
Nf1	A	G	11: 79,450,275 (GRCm39)	E487G	probably benign	Het
Nlrp2	A	G	7: 5,331,034 (GRCm39)	L454P	probably damaging	Het
Or8k18	A	T	2: 86,085,529 (GRCm39)	C169*	probably null	Het
Rad51	T	A	2: 118,949,183 (GRCm39)	I61K	probably benign	Het
Rfx8	A	T	1: 39,709,733 (GRCm39)	H431Q	probably damaging	Het
Sspo	A	G	6: 48,451,377 (GRCm39)	N2725S	probably damaging	Het
Zfp879	T	C	11: 50,729,281 (GRCm39)	Y39C	probably damaging	Het

Other mutations in Trim16

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00661:Trim16	APN	11	62,728,058 (GRCm39)	splice site	probably benign
IGL01060:Trim16	APN	11	62,711,530 (GRCm39)	missense	probably benign	0.06
IGL01568:Trim16	APN	11	62,711,684 (GRCm39)	missense	probably benign	0.05
IGL02519:Trim16	APN	11	62,724,905 (GRCm39)	missense	possibly damaging	0.49
IGL02662:Trim16	APN	11	62,731,383 (GRCm39)	missense	possibly damaging	0.91
FR4589:Trim16	UTSW	11	62,711,521 (GRCm39)	intron	probably benign
FR4976:Trim16	UTSW	11	62,711,515 (GRCm39)	intron	probably benign
R0007:Trim16	UTSW	11	62,719,944 (GRCm39)	missense	probably benign	0.00
R0007:Trim16	UTSW	11	62,719,944 (GRCm39)	missense	probably benign	0.00
R0346:Trim16	UTSW	11	62,731,520 (GRCm39)	missense	probably benign	0.00
R0410:Trim16	UTSW	11	62,711,297 (GRCm39)	start gained	probably benign
R1725:Trim16	UTSW	11	62,711,331 (GRCm39)	start codon destroyed	possibly damaging	0.91
R3845:Trim16	UTSW	11	62,727,498 (GRCm39)	splice site	probably benign
R3879:Trim16	UTSW	11	62,731,433 (GRCm39)	missense	probably damaging	1.00
R5023:Trim16	UTSW	11	62,727,638 (GRCm39)	missense	probably benign	0.36
R5344:Trim16	UTSW	11	62,711,751 (GRCm39)	missense	probably damaging	1.00
R6919:Trim16	UTSW	11	62,731,695 (GRCm39)	missense	possibly damaging	0.86
R7490:Trim16	UTSW	11	62,724,949 (GRCm39)	missense	probably damaging	1.00
R7525:Trim16	UTSW	11	62,711,580 (GRCm39)	missense	probably damaging	1.00
R8354:Trim16	UTSW	11	62,727,587 (GRCm39)	missense	probably benign	0.01
R8439:Trim16	UTSW	11	62,741,414 (GRCm39)	missense	probably benign	0.10
R8754:Trim16	UTSW	11	62,731,763 (GRCm39)	missense	probably benign	0.01
R9581:Trim16	UTSW	11	62,727,557 (GRCm39)	missense	probably damaging	0.98
R9599:Trim16	UTSW	11	62,731,644 (GRCm39)	missense	probably damaging	0.97
R9789:Trim16	UTSW	11	62,720,026 (GRCm39)	critical splice donor site	probably null
X0026:Trim16	UTSW	11	62,719,963 (GRCm39)	missense	probably benign	0.02
Z1186:Trim16	UTSW	11	62,711,428 (GRCm39)	missense	probably benign
Z1186:Trim16	UTSW	11	62,731,675 (GRCm39)	missense	probably benign	0.00
Z1186:Trim16	UTSW	11	62,731,572 (GRCm39)	missense	probably benign
Z1186:Trim16	UTSW	11	62,727,643 (GRCm39)	missense	probably benign	0.00
Z1186:Trim16	UTSW	11	62,711,518 (GRCm39)	intron	probably benign
Z1186:Trim16	UTSW	11	62,711,516 (GRCm39)	intron	probably benign
Z1186:Trim16	UTSW	11	62,711,502 (GRCm39)	missense	probably benign
Z1187:Trim16	UTSW	11	62,731,675 (GRCm39)	missense	probably benign	0.00
Z1187:Trim16	UTSW	11	62,731,572 (GRCm39)	missense	probably benign
Z1187:Trim16	UTSW	11	62,727,643 (GRCm39)	missense	probably benign	0.00
Z1187:Trim16	UTSW	11	62,711,521 (GRCm39)	intron	probably benign
Z1187:Trim16	UTSW	11	62,711,520 (GRCm39)	intron	probably benign
Z1187:Trim16	UTSW	11	62,711,516 (GRCm39)	intron	probably benign
Z1187:Trim16	UTSW	11	62,711,502 (GRCm39)	missense	probably benign
Z1187:Trim16	UTSW	11	62,711,428 (GRCm39)	missense	probably benign
Z1188:Trim16	UTSW	11	62,711,502 (GRCm39)	missense	probably benign
Z1188:Trim16	UTSW	11	62,711,516 (GRCm39)	intron	probably benign
Z1188:Trim16	UTSW	11	62,711,521 (GRCm39)	intron	probably benign
Z1188:Trim16	UTSW	11	62,727,643 (GRCm39)	missense	probably benign	0.00
Z1188:Trim16	UTSW	11	62,731,572 (GRCm39)	missense	probably benign
Z1188:Trim16	UTSW	11	62,731,675 (GRCm39)	missense	probably benign	0.00
Z1188:Trim16	UTSW	11	62,711,428 (GRCm39)	missense	probably benign
Z1189:Trim16	UTSW	11	62,731,675 (GRCm39)	missense	probably benign	0.00
Z1189:Trim16	UTSW	11	62,731,572 (GRCm39)	missense	probably benign
Z1189:Trim16	UTSW	11	62,727,643 (GRCm39)	missense	probably benign	0.00
Z1189:Trim16	UTSW	11	62,711,520 (GRCm39)	intron	probably benign
Z1189:Trim16	UTSW	11	62,711,517 (GRCm39)	intron	probably benign
Z1189:Trim16	UTSW	11	62,711,516 (GRCm39)	intron	probably benign
Z1189:Trim16	UTSW	11	62,711,502 (GRCm39)	missense	probably benign
Z1189:Trim16	UTSW	11	62,711,428 (GRCm39)	missense	probably benign
Z1190:Trim16	UTSW	11	62,731,675 (GRCm39)	missense	probably benign	0.00
Z1190:Trim16	UTSW	11	62,731,572 (GRCm39)	missense	probably benign
Z1190:Trim16	UTSW	11	62,727,643 (GRCm39)	missense	probably benign	0.00
Z1190:Trim16	UTSW	11	62,711,521 (GRCm39)	intron	probably benign
Z1190:Trim16	UTSW	11	62,711,519 (GRCm39)	intron	probably benign
Z1190:Trim16	UTSW	11	62,711,516 (GRCm39)	intron	probably benign
Z1190:Trim16	UTSW	11	62,711,502 (GRCm39)	missense	probably benign
Z1190:Trim16	UTSW	11	62,711,428 (GRCm39)	missense	probably benign
Z1191:Trim16	UTSW	11	62,711,502 (GRCm39)	missense	probably benign
Z1191:Trim16	UTSW	11	62,711,428 (GRCm39)	missense	probably benign
Z1191:Trim16	UTSW	11	62,731,675 (GRCm39)	missense	probably benign	0.00
Z1191:Trim16	UTSW	11	62,731,572 (GRCm39)	missense	probably benign
Z1191:Trim16	UTSW	11	62,727,643 (GRCm39)	missense	probably benign	0.00
Z1191:Trim16	UTSW	11	62,711,516 (GRCm39)	intron	probably benign
Z1192:Trim16	UTSW	11	62,711,428 (GRCm39)	missense	probably benign
Z1192:Trim16	UTSW	11	62,731,675 (GRCm39)	missense	probably benign	0.00
Z1192:Trim16	UTSW	11	62,731,572 (GRCm39)	missense	probably benign
Z1192:Trim16	UTSW	11	62,727,643 (GRCm39)	missense	probably benign	0.00
Z1192:Trim16	UTSW	11	62,711,521 (GRCm39)	intron	probably benign
Z1192:Trim16	UTSW	11	62,711,516 (GRCm39)	intron	probably benign
Z1192:Trim16	UTSW	11	62,711,502 (GRCm39)	missense	probably benign

Posted On

2014-01-21