Incidental Mutation 'IGL01660:Actl11'
ID103151
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Actl11
Ensembl Gene ENSMUSG00000066368
Gene Nameactin-like 11
Synonyms
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.075) question?
Stock #IGL01660
Quality Score
Status
Chromosome9
Chromosomal Location107928469-107932461 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to C at 107929048 bp
ZygosityHeterozygous
Amino Acid Change Valine to Alanine at position 190 (V190A)
Ref Sequence ENSEMBL: ENSMUSP00000082150 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000085073]
Predicted Effect probably benign
Transcript: ENSMUST00000085073
AA Change: V190A

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000082150
Gene: ENSMUSG00000066368
AA Change: V190A

DomainStartEndE-ValueType
low complexity region 223 239 N/A INTRINSIC
low complexity region 301 309 N/A INTRINSIC
low complexity region 374 391 N/A INTRINSIC
low complexity region 492 507 N/A INTRINSIC
low complexity region 697 710 N/A INTRINSIC
ACTIN 858 1207 4.26e-81 SMART
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 38 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
9130011E15Rik A T 19: 45,940,476 L393H probably damaging Het
Acta2 A G 19: 34,251,791 I66T probably damaging Het
Ankub1 T A 3: 57,690,396 Y51F possibly damaging Het
Ccdc63 G A 5: 122,110,964 S434L possibly damaging Het
Cdan1 T A 2: 120,725,653 I711F possibly damaging Het
Cep170b C A 12: 112,744,160 N1474K probably damaging Het
Cyp2c40 A G 19: 39,786,810 S333P probably damaging Het
Dars A G 1: 128,415,344 probably benign Het
Dock3 T A 9: 107,032,364 probably benign Het
Dsp A G 13: 38,176,495 I359V possibly damaging Het
Fut8 T G 12: 77,450,258 L414* probably null Het
Gja1 A G 10: 56,388,448 Y301C probably damaging Het
Glipr1l1 T C 10: 112,072,279 S161P probably damaging Het
Gpat4 A T 8: 23,175,338 probably null Het
Grhl1 T A 12: 24,608,578 probably null Het
Hectd3 T C 4: 116,996,372 V181A possibly damaging Het
Htr2a T A 14: 74,705,754 I258N probably damaging Het
Hyou1 T A 9: 44,381,117 D83E possibly damaging Het
Myh10 T A 11: 68,785,889 L862Q probably benign Het
Nkx2-2 T C 2: 147,185,913 S36G probably benign Het
Nsun2 T A 13: 69,623,249 V326E probably benign Het
Nuak2 T C 1: 132,331,570 V362A probably benign Het
Nyap2 G A 1: 81,191,927 C133Y probably damaging Het
Oas2 T C 5: 120,741,223 T351A probably benign Het
Olfr1025-ps1 T C 2: 85,918,564 I213T probably benign Het
Olfr279 C T 15: 98,498,195 T241I probably damaging Het
Pde4d A T 13: 109,938,072 I404F probably damaging Het
Pga5 A G 19: 10,675,092 S95P probably damaging Het
Pitpnm2 A T 5: 124,123,194 D947E probably damaging Het
Pla2g10 C T 16: 13,728,086 R28H probably damaging Het
Prlr A G 15: 10,317,590 D84G probably damaging Het
Rbm15b C T 9: 106,885,709 G420D probably damaging Het
Tbcd A G 11: 121,605,327 T1063A probably benign Het
Tmc2 C T 2: 130,260,224 Q770* probably null Het
Tpo T C 12: 30,119,400 probably benign Het
Vim A G 2: 13,574,813 N128D probably damaging Het
Vmn1r21 A T 6: 57,844,237 I74N probably damaging Het
Vmn2r52 A C 7: 10,159,180 I677M probably damaging Het
Other mutations in Actl11
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01081:Actl11 APN 9 107928982 missense possibly damaging 0.49
IGL01396:Actl11 APN 9 107928765 missense possibly damaging 0.71
IGL01622:Actl11 APN 9 107928576 missense probably benign 0.03
IGL01623:Actl11 APN 9 107928576 missense probably benign 0.03
IGL01912:Actl11 APN 9 107929645 missense probably damaging 0.98
IGL02002:Actl11 APN 9 107929330 missense probably benign 0.08
IGL02266:Actl11 APN 9 107931183 missense possibly damaging 0.76
IGL02535:Actl11 APN 9 107929937 missense possibly damaging 0.71
IGL02692:Actl11 APN 9 107929308 missense probably benign 0.06
IGL02744:Actl11 APN 9 107929862 missense probably benign 0.04
IGL02864:Actl11 APN 9 107928987 missense probably benign 0.25
IGL03037:Actl11 APN 9 107930095 missense probably damaging 0.99
IGL03085:Actl11 APN 9 107929550 missense probably damaging 0.98
R0167:Actl11 UTSW 9 107929770 missense probably damaging 1.00
R0304:Actl11 UTSW 9 107929768 missense probably damaging 1.00
R0959:Actl11 UTSW 9 107931235 missense probably damaging 1.00
R1499:Actl11 UTSW 9 107931483 missense probably damaging 1.00
R1616:Actl11 UTSW 9 107931936 missense probably benign 0.39
R1694:Actl11 UTSW 9 107930008 missense probably damaging 1.00
R1927:Actl11 UTSW 9 107929537 missense possibly damaging 0.88
R2081:Actl11 UTSW 9 107930197 missense probably benign
R2939:Actl11 UTSW 9 107931210 missense possibly damaging 0.84
R3427:Actl11 UTSW 9 107929770 missense probably damaging 1.00
R4812:Actl11 UTSW 9 107931130 missense probably damaging 0.99
R4843:Actl11 UTSW 9 107929492 missense possibly damaging 0.61
R4972:Actl11 UTSW 9 107929956 missense probably benign 0.07
R4989:Actl11 UTSW 9 107931416 missense probably damaging 1.00
R4996:Actl11 UTSW 9 107931735 missense possibly damaging 0.77
R5320:Actl11 UTSW 9 107931004 missense possibly damaging 0.73
R5546:Actl11 UTSW 9 107929633 missense probably benign 0.00
R5810:Actl11 UTSW 9 107929221 missense probably benign 0.23
R6302:Actl11 UTSW 9 107929573 missense probably benign 0.12
R6412:Actl11 UTSW 9 107929917 missense probably benign 0.01
R6835:Actl11 UTSW 9 107930562 missense probably benign
R6891:Actl11 UTSW 9 107929147 missense probably benign 0.03
R7195:Actl11 UTSW 9 107928870 nonsense probably null
R7212:Actl11 UTSW 9 107928657 missense probably damaging 0.99
X0024:Actl11 UTSW 9 107930505 missense probably benign 0.01
Z1176:Actl11 UTSW 9 107931700 missense probably benign 0.20
Posted On2014-01-21