Incidental Mutation 'IGL01663:Il10'
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Il10
Ensembl Gene ENSMUSG00000016529
Gene Nameinterleukin 10
SynonymsIL-10, cytokine synthesis inhibitory factor
Accession Numbers

Ncbi RefSeq: NM_010548.2; MGI:96537

Is this an essential gene? Probably essential (E-score: 0.818) question?
Stock #IGL01663
Quality Score
Chromosomal Location131019845-131024974 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to G at 131021414 bp
Amino Acid Change Glutamic Acid to Glycine at position 104 (E104G)
Ref Sequence ENSEMBL: ENSMUSP00000016673 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000016673]
PDB Structure X-ray structure of mouse interleukin-10 mutant - S1_E8del, C149Y [X-RAY DIFFRACTION]
Predicted Effect probably benign
Transcript: ENSMUST00000016673
AA Change: E104G

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000016673
Gene: ENSMUSG00000016529
AA Change: E104G

low complexity region 6 13 N/A INTRINSIC
IL10 37 173 1.05e-103 SMART
Coding Region Coverage
Validation Efficiency
MGI Phenotype Strain: 1857199; 3521569
FUNCTION: This gene encodes an anti-inflammatory cytokine that is a member of the class-2 cytokine family. The encoded protein is secreted by cells of both the innate and adaptive immune systems and is crucial for limiting the immune response to a broad range of pathogens. It also has been shown to suppress autoimmune responses. This protein mediates it's immunosuppressive signal through a specific interleukin 10 receptor complex. Aberrant functioning of this gene is associated with numerous immune disorders including graft-versus-host disease, and increased susceptibility to HIV-1 infection and rheumatoid arthritis. [provided by RefSeq, Sep 2015]
PHENOTYPE: Homozygotes for a targeted null mutation exhibit retarded growth, anemia, chronic enterocolitis, a high incidence of colorectal adenocarcinomas, and altered responses to various infectious organisms such as Mycobacterium bovis and Leishmania donovani. [provided by MGI curators]
Allele List at MGI

All alleles(14) : Targeted(14

Other mutations in this stock
Total: 33 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acaca A G 11: 84,277,802 I1085V possibly damaging Het
Adamts16 T C 13: 70,793,141 T376A probably benign Het
Aifm3 T A 16: 17,502,786 probably null Het
Ankrd16 A G 2: 11,778,662 E25G probably damaging Het
Ano6 T A 15: 95,967,614 probably null Het
Cdh18 T C 15: 23,445,991 I509T possibly damaging Het
Cdon A G 9: 35,483,214 T919A possibly damaging Het
Clca3a2 G A 3: 144,817,155 P148L probably damaging Het
Dnph1 G T 17: 46,498,482 R74L probably benign Het
Epha6 C T 16: 59,775,644 A895T probably damaging Het
Exoc3l4 T A 12: 111,429,411 probably benign Het
Fbll1 A G 11: 35,797,821 I205T probably damaging Het
Frem2 T A 3: 53,517,013 H3001L probably damaging Het
Galk2 A G 2: 125,983,179 N432D probably benign Het
Gm7535 A C 17: 17,911,357 probably benign Het
Il1a T C 2: 129,304,717 K152R probably benign Het
Kdm1b T A 13: 47,073,737 N568K probably damaging Het
Kmt2c A C 5: 25,310,670 L2725R probably damaging Het
Krba1 G T 6: 48,411,754 L527F probably damaging Het
Lrp2 A G 2: 69,428,706 S4547P probably benign Het
Nin G T 12: 70,043,665 A992E possibly damaging Het
Olfr510 T A 7: 108,667,891 H158Q probably benign Het
Olfr740 G A 14: 50,453,150 V33M probably benign Het
Pcdhb1 A G 18: 37,267,133 I712M possibly damaging Het
Prmt2 C T 10: 76,217,309 probably null Het
Rbm20 T G 19: 53,840,995 V608G probably damaging Het
Smarcc2 C T 10: 128,488,977 probably benign Het
Speer3 A T 5: 13,793,222 R48* probably null Het
Tlr1 A T 5: 64,925,073 N720K possibly damaging Het
Tnfrsf21 A T 17: 43,087,811 M603L probably benign Het
Ttc3 T A 16: 94,409,731 probably null Het
Usp4 C A 9: 108,365,880 A249E possibly damaging Het
Wdr20 T A 12: 110,793,514 V278E probably damaging Het
Other mutations in Il10
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01664:Il10 APN 1 131021477 missense possibly damaging 0.95
R0139:Il10 UTSW 1 131022534 missense probably damaging 0.98
R1244:Il10 UTSW 1 131024216 missense probably damaging 0.99
R1471:Il10 UTSW 1 131021373 nonsense probably null
R2034:Il10 UTSW 1 131024185 missense probably benign
R2063:Il10 UTSW 1 131020033 missense probably damaging 1.00
R5624:Il10 UTSW 1 131024203 missense probably benign 0.32
R7650:Il10 UTSW 1 131021455 missense probably benign 0.13
R7840:Il10 UTSW 1 131020068 missense probably benign
R8280:Il10 UTSW 1 131020012 missense possibly damaging 0.91
Z1177:Il10 UTSW 1 131021395 missense probably damaging 1.00
Posted On2014-01-21