Incidental Mutation 'IGL01663:Il10'
ID 103229
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Il10
Ensembl Gene ENSMUSG00000016529
Gene Name interleukin 10
Synonyms cytokine synthesis inhibitory factor, IL-10
Accession Numbers
Essential gene? Possibly essential (E-score: 0.741) question?
Stock # IGL01663
Quality Score
Status
Chromosome 1
Chromosomal Location 130947582-130952711 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 130949151 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamic Acid to Glycine at position 104 (E104G)
Ref Sequence ENSEMBL: ENSMUSP00000016673 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000016673]
AlphaFold P18893
PDB Structure X-ray structure of mouse interleukin-10 mutant - S1_E8del, C149Y [X-RAY DIFFRACTION]
Predicted Effect probably benign
Transcript: ENSMUST00000016673
AA Change: E104G

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000016673
Gene: ENSMUSG00000016529
AA Change: E104G

DomainStartEndE-ValueType
low complexity region 6 13 N/A INTRINSIC
IL10 37 173 1.05e-103 SMART
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: This gene encodes an anti-inflammatory cytokine that is a member of the class-2 cytokine family. The encoded protein is secreted by cells of both the innate and adaptive immune systems and is crucial for limiting the immune response to a broad range of pathogens. It also has been shown to suppress autoimmune responses. This protein mediates it's immunosuppressive signal through a specific interleukin 10 receptor complex. Aberrant functioning of this gene is associated with numerous immune disorders including graft-versus-host disease, and increased susceptibility to HIV-1 infection and rheumatoid arthritis. [provided by RefSeq, Sep 2015]
PHENOTYPE: Homozygotes for a targeted null mutation exhibit retarded growth, anemia, chronic enterocolitis, a high incidence of colorectal adenocarcinomas, and altered responses to various infectious organisms such as Mycobacterium bovis and Leishmania donovani. [provided by MGI curators]
Allele List at MGI

All alleles(14) : Targeted(14) 
Other mutations in this stock
Total: 33 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acaca A G 11: 84,168,628 (GRCm39) I1085V possibly damaging Het
Adamts16 T C 13: 70,941,260 (GRCm39) T376A probably benign Het
Aifm3 T A 16: 17,320,650 (GRCm39) probably null Het
Ankrd16 A G 2: 11,783,473 (GRCm39) E25G probably damaging Het
Ano6 T A 15: 95,865,495 (GRCm39) probably null Het
Cdh18 T C 15: 23,446,077 (GRCm39) I509T possibly damaging Het
Cdon A G 9: 35,394,510 (GRCm39) T919A possibly damaging Het
Clca3a2 G A 3: 144,522,916 (GRCm39) P148L probably damaging Het
Dnph1 G T 17: 46,809,408 (GRCm39) R74L probably benign Het
Epha6 C T 16: 59,596,007 (GRCm39) A895T probably damaging Het
Exoc3l4 T A 12: 111,395,845 (GRCm39) probably benign Het
Fbll1 A G 11: 35,688,648 (GRCm39) I205T probably damaging Het
Frem2 T A 3: 53,424,434 (GRCm39) H3001L probably damaging Het
Galk2 A G 2: 125,825,099 (GRCm39) N432D probably benign Het
Gm7535 A C 17: 18,131,619 (GRCm39) probably benign Het
Il1a T C 2: 129,146,637 (GRCm39) K152R probably benign Het
Kdm1b T A 13: 47,227,213 (GRCm39) N568K probably damaging Het
Kmt2c A C 5: 25,515,668 (GRCm39) L2725R probably damaging Het
Krba1 G T 6: 48,388,688 (GRCm39) L527F probably damaging Het
Lrp2 A G 2: 69,259,050 (GRCm39) S4547P probably benign Het
Nin G T 12: 70,090,439 (GRCm39) A992E possibly damaging Het
Or11g7 G A 14: 50,690,607 (GRCm39) V33M probably benign Het
Or5p81 T A 7: 108,267,098 (GRCm39) H158Q probably benign Het
Pcdhb1 A G 18: 37,400,186 (GRCm39) I712M possibly damaging Het
Prmt2 C T 10: 76,053,143 (GRCm39) probably null Het
Rbm20 T G 19: 53,829,426 (GRCm39) V608G probably damaging Het
Smarcc2 C T 10: 128,324,846 (GRCm39) probably benign Het
Speer3 A T 5: 13,843,236 (GRCm39) R48* probably null Het
Tlr1 A T 5: 65,082,416 (GRCm39) N720K possibly damaging Het
Tnfrsf21 A T 17: 43,398,702 (GRCm39) M603L probably benign Het
Ttc3 T A 16: 94,210,590 (GRCm39) probably null Het
Usp4 C A 9: 108,243,079 (GRCm39) A249E possibly damaging Het
Wdr20 T A 12: 110,759,948 (GRCm39) V278E probably damaging Het
Other mutations in Il10
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01664:Il10 APN 1 130,949,214 (GRCm39) missense possibly damaging 0.95
R0139:Il10 UTSW 1 130,950,271 (GRCm39) missense probably damaging 0.98
R1244:Il10 UTSW 1 130,951,953 (GRCm39) missense probably damaging 0.99
R1471:Il10 UTSW 1 130,949,110 (GRCm39) nonsense probably null
R2034:Il10 UTSW 1 130,951,922 (GRCm39) missense probably benign
R2063:Il10 UTSW 1 130,947,770 (GRCm39) missense probably damaging 1.00
R5624:Il10 UTSW 1 130,951,940 (GRCm39) missense probably benign 0.32
R7650:Il10 UTSW 1 130,949,192 (GRCm39) missense probably benign 0.13
R7840:Il10 UTSW 1 130,947,805 (GRCm39) missense probably benign
R8280:Il10 UTSW 1 130,947,749 (GRCm39) missense possibly damaging 0.91
Z1177:Il10 UTSW 1 130,949,132 (GRCm39) missense probably damaging 1.00
Posted On 2014-01-21