Incidental Mutation 'IGL01664:Olfr668'
ID103253
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr668
Ensembl Gene ENSMUSG00000057770
Gene Nameolfactory receptor 668
SynonymsGA_x6K02T2PBJ9-7554614-7553658, MOR34-3
Accession Numbers
Is this an essential gene? Possibly non essential (E-score: 0.301) question?
Stock #IGL01664
Quality Score
Status
Chromosome7
Chromosomal Location104922291-104928057 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to C at 104925104 bp
ZygosityHeterozygous
Amino Acid Change Tyrosine to Cysteine at position 220 (Y220C)
Ref Sequence ENSEMBL: ENSMUSP00000150824 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000164391] [ENSMUST00000215359] [ENSMUST00000217177]
Predicted Effect probably damaging
Transcript: ENSMUST00000164391
AA Change: Y220C

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000130975
Gene: ENSMUSG00000057770
AA Change: Y220C

DomainStartEndE-ValueType
Pfam:7tm_4 33 313 7.2e-103 PFAM
Pfam:7TM_GPCR_Srsx 37 210 4.7e-10 PFAM
Pfam:7tm_1 43 295 4.6e-18 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000215359
AA Change: Y220C

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Predicted Effect probably benign
Transcript: ENSMUST00000217177
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 19 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Col19a1 T A 1: 24,561,335 Y42F unknown Het
Ddx31 T C 2: 28,875,835 probably benign Het
Fbln2 G A 6: 91,233,457 D128N probably damaging Het
Fgf7 G T 2: 126,035,987 M91I probably benign Het
Gm28539 A G 16: 18,836,773 H31R possibly damaging Het
Hivep1 T G 13: 42,159,279 V1665G probably benign Het
Ifih1 T C 2: 62,611,700 probably benign Het
Il10 G T 1: 131,021,477 R125L possibly damaging Het
Kalrn C T 16: 34,294,161 R574H probably damaging Het
Lmln A G 16: 33,080,987 E251G probably benign Het
Olfr1507 T C 14: 52,490,545 N57D probably benign Het
Olfr681 T A 7: 105,122,216 L253Q probably damaging Het
Otol1 A G 3: 70,027,797 D374G probably benign Het
Pcdhb15 T C 18: 37,474,261 V182A probably benign Het
Polr3e T C 7: 120,931,317 probably benign Het
Sectm1a A T 11: 121,069,044 S149T possibly damaging Het
Slfn10-ps A G 11: 83,035,935 noncoding transcript Het
Sox1ot A G 8: 12,430,670 noncoding transcript Het
Tnik G T 3: 28,638,479 G895C probably damaging Het
Other mutations in Olfr668
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02250:Olfr668 APN 7 104925015 missense probably damaging 1.00
IGL02743:Olfr668 APN 7 104924868 missense probably damaging 0.98
IGL03105:Olfr668 APN 7 104925764 unclassified probably benign
IGL03252:Olfr668 APN 7 104925387 missense probably benign 0.16
IGL03387:Olfr668 APN 7 104925373 missense probably benign 0.01
R1534:Olfr668 UTSW 7 104925414 missense possibly damaging 0.95
R2509:Olfr668 UTSW 7 104925687 missense probably benign 0.40
R2510:Olfr668 UTSW 7 104925687 missense probably benign 0.40
R4739:Olfr668 UTSW 7 104924810 missense possibly damaging 0.91
R4995:Olfr668 UTSW 7 104925735 missense probably benign 0.01
R5071:Olfr668 UTSW 7 104925493 missense probably benign
R5074:Olfr668 UTSW 7 104925493 missense probably benign
R5208:Olfr668 UTSW 7 104925726 missense probably benign
R5293:Olfr668 UTSW 7 104925279 missense probably benign 0.00
R6061:Olfr668 UTSW 7 104925392 missense probably benign 0.28
R6063:Olfr668 UTSW 7 104925392 missense probably benign 0.28
R6064:Olfr668 UTSW 7 104925392 missense probably benign 0.28
R6172:Olfr668 UTSW 7 104925296 missense probably benign 0.40
R6492:Olfr668 UTSW 7 104925645 missense possibly damaging 0.60
R6933:Olfr668 UTSW 7 104925123 missense probably benign 0.21
R7040:Olfr668 UTSW 7 104925510 missense probably benign 0.02
R7587:Olfr668 UTSW 7 104925056 missense probably benign 0.28
R7841:Olfr668 UTSW 7 104924859 missense possibly damaging 0.59
R7869:Olfr668 UTSW 7 104925104 missense probably damaging 1.00
R7902:Olfr668 UTSW 7 104925350 missense probably damaging 1.00
R7924:Olfr668 UTSW 7 104924859 missense possibly damaging 0.59
R7952:Olfr668 UTSW 7 104925104 missense probably damaging 1.00
R7985:Olfr668 UTSW 7 104925350 missense probably damaging 1.00
Z1177:Olfr668 UTSW 7 104924993 missense probably damaging 1.00
Posted On2014-01-21