Incidental Mutation 'IGL01665:Ints7'
ID 103300
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Ints7
Ensembl Gene ENSMUSG00000037461
Gene Name integrator complex subunit 7
Synonyms 5930412E23Rik
Accession Numbers
Essential gene? Probably essential (E-score: 0.952) question?
Stock # IGL01665
Quality Score
Status
Chromosome 1
Chromosomal Location 191307748-191355800 bp(+) (GRCm39)
Type of Mutation splice site
DNA Base Change (assembly) C to T at 191345331 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000141741 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000045450] [ENSMUST00000193569] [ENSMUST00000194785] [ENSMUST00000194877]
AlphaFold no structure available at present
Predicted Effect probably benign
Transcript: ENSMUST00000045450
SMART Domains Protein: ENSMUSP00000036277
Gene: ENSMUSG00000037461

DomainStartEndE-ValueType
SCOP:d1gw5a_ 76 530 1e-10 SMART
low complexity region 937 960 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000193569
Predicted Effect noncoding transcript
Transcript: ENSMUST00000193961
Predicted Effect probably benign
Transcript: ENSMUST00000194785
Predicted Effect probably benign
Transcript: ENSMUST00000194877
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a subunit of the integrator complex. The integrator complex associates with the C-terminal domain of RNA polymerase II and mediates 3'-end processing of the small nuclear RNAs U1 and U2. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2010]
Allele List at MGI
Other mutations in this stock
Total: 27 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acsbg1 T A 9: 54,530,004 (GRCm39) I231L probably benign Het
Adcyap1 T A 17: 93,507,506 (GRCm39) V22D probably damaging Het
Adgra3 T C 5: 50,164,272 (GRCm39) T236A possibly damaging Het
Adipor2 A T 6: 119,338,887 (GRCm39) L122H probably benign Het
Atp1a4 T C 1: 172,074,291 (GRCm39) I321V probably benign Het
Bhmt2 A T 13: 93,799,661 (GRCm39) Y258* probably null Het
C230029F24Rik T A 1: 49,377,253 (GRCm39) noncoding transcript Het
Ccpg1 T A 9: 72,913,159 (GRCm39) F232I probably damaging Het
Cd83 A T 13: 43,955,153 (GRCm39) T195S probably benign Het
Cdcp3 G T 7: 130,848,386 (GRCm39) G847* probably null Het
Cfap70 G A 14: 20,453,186 (GRCm39) T897M probably damaging Het
Cyp3a11 T A 5: 145,805,475 (GRCm39) M181L probably benign Het
Frem2 C T 3: 53,457,083 (GRCm39) V2090I probably benign Het
Gm45234 A G 6: 124,723,571 (GRCm39) probably benign Het
Gm7964 T A 7: 83,406,341 (GRCm39) noncoding transcript Het
Igsf9 T A 1: 172,319,738 (GRCm39) C39* probably null Het
Il1rap A T 16: 26,541,463 (GRCm39) D568V probably damaging Het
Lsamp C T 16: 41,964,375 (GRCm39) R250* probably null Het
Oit3 T A 10: 59,274,731 (GRCm39) D23V probably damaging Het
Pcdh17 T A 14: 84,684,442 (GRCm39) L303Q probably damaging Het
Pcdhb1 T A 18: 37,400,450 (GRCm39) N800K probably benign Het
Plce1 A G 19: 38,513,331 (GRCm39) D210G probably benign Het
Plekhb2 T A 1: 34,908,411 (GRCm39) Y152N probably damaging Het
Rbp3 T C 14: 33,678,088 (GRCm39) S679P probably benign Het
Rps6kc1 T C 1: 190,643,854 (GRCm39) T2A possibly damaging Het
Tmem167 T A 13: 90,246,504 (GRCm39) S9R probably damaging Het
Xpnpep1 A T 19: 52,985,463 (GRCm39) S522T probably benign Het
Other mutations in Ints7
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00904:Ints7 APN 1 191,328,276 (GRCm39) splice site probably null
IGL01285:Ints7 APN 1 191,347,890 (GRCm39) missense probably benign 0.00
IGL01289:Ints7 APN 1 191,347,890 (GRCm39) missense probably benign 0.00
IGL01572:Ints7 APN 1 191,347,905 (GRCm39) missense possibly damaging 0.71
IGL02059:Ints7 APN 1 191,347,872 (GRCm39) missense probably benign 0.23
IGL02684:Ints7 APN 1 191,345,749 (GRCm39) critical splice acceptor site probably null
IGL02686:Ints7 APN 1 191,318,704 (GRCm39) missense probably damaging 1.00
IGL02812:Ints7 APN 1 191,351,853 (GRCm39) missense probably damaging 1.00
IGL03119:Ints7 APN 1 191,342,477 (GRCm39) missense probably damaging 1.00
IGL03162:Ints7 APN 1 191,353,524 (GRCm39) utr 3 prime probably benign
PIT4810001:Ints7 UTSW 1 191,328,348 (GRCm39) missense probably damaging 0.99
R0294:Ints7 UTSW 1 191,344,003 (GRCm39) missense possibly damaging 0.91
R0479:Ints7 UTSW 1 191,346,666 (GRCm39) splice site probably null
R0698:Ints7 UTSW 1 191,326,576 (GRCm39) missense probably damaging 0.97
R1420:Ints7 UTSW 1 191,345,169 (GRCm39) missense possibly damaging 0.73
R1680:Ints7 UTSW 1 191,353,274 (GRCm39) splice site probably null
R1781:Ints7 UTSW 1 191,328,396 (GRCm39) missense possibly damaging 0.95
R2141:Ints7 UTSW 1 191,336,972 (GRCm39) missense possibly damaging 0.73
R2291:Ints7 UTSW 1 191,338,315 (GRCm39) splice site probably null
R4718:Ints7 UTSW 1 191,315,389 (GRCm39) missense possibly damaging 0.60
R4741:Ints7 UTSW 1 191,351,747 (GRCm39) missense probably benign 0.29
R4797:Ints7 UTSW 1 191,329,045 (GRCm39) missense probably damaging 1.00
R4812:Ints7 UTSW 1 191,326,542 (GRCm39) missense possibly damaging 0.73
R4826:Ints7 UTSW 1 191,344,018 (GRCm39) missense probably damaging 0.97
R4870:Ints7 UTSW 1 191,328,443 (GRCm39) missense probably damaging 0.97
R5169:Ints7 UTSW 1 191,345,202 (GRCm39) missense probably benign 0.00
R5281:Ints7 UTSW 1 191,347,883 (GRCm39) missense possibly damaging 0.90
R5694:Ints7 UTSW 1 191,318,730 (GRCm39) missense probably damaging 1.00
R5752:Ints7 UTSW 1 191,308,005 (GRCm39) missense probably benign 0.00
R6048:Ints7 UTSW 1 191,353,524 (GRCm39) utr 3 prime probably benign
R6341:Ints7 UTSW 1 191,345,239 (GRCm39) missense probably damaging 1.00
R6419:Ints7 UTSW 1 191,334,414 (GRCm39) missense possibly damaging 0.69
R7037:Ints7 UTSW 1 191,351,717 (GRCm39) missense probably benign 0.16
R7163:Ints7 UTSW 1 191,349,949 (GRCm39) missense possibly damaging 0.67
R7603:Ints7 UTSW 1 191,328,336 (GRCm39) missense probably damaging 1.00
R7801:Ints7 UTSW 1 191,347,859 (GRCm39) missense possibly damaging 0.84
R7899:Ints7 UTSW 1 191,353,427 (GRCm39) missense probably damaging 1.00
R8034:Ints7 UTSW 1 191,345,183 (GRCm39) frame shift probably null
R8034:Ints7 UTSW 1 191,345,180 (GRCm39) frame shift probably null
R8231:Ints7 UTSW 1 191,328,465 (GRCm39) nonsense probably null
R8251:Ints7 UTSW 1 191,353,545 (GRCm39) missense unknown
R8520:Ints7 UTSW 1 191,314,603 (GRCm39) missense probably damaging 1.00
R8966:Ints7 UTSW 1 191,351,717 (GRCm39) missense probably benign 0.16
R9198:Ints7 UTSW 1 191,351,872 (GRCm39) missense probably benign 0.42
R9382:Ints7 UTSW 1 191,351,793 (GRCm39) missense probably damaging 1.00
Z1177:Ints7 UTSW 1 191,342,570 (GRCm39) missense probably benign 0.06
Posted On 2014-01-21