Incidental Mutation 'IGL01667:Olfr1441'
ID103326
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr1441
Ensembl Gene ENSMUSG00000050815
Gene Nameolfactory receptor 1441
SynonymsGA_x6K02T2RE5P-2753221-2754177, MOR215-2
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.076) question?
Stock #IGL01667
Quality Score
Status
Chromosome19
Chromosomal Location12417433-12423569 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to C at 12422756 bp
ZygosityHeterozygous
Amino Acid Change Valine to Alanine at position 149 (V149A)
Ref Sequence ENSEMBL: ENSMUSP00000150739 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000059033] [ENSMUST00000214153] [ENSMUST00000216506]
Predicted Effect probably benign
Transcript: ENSMUST00000059033
AA Change: V149A

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000061963
Gene: ENSMUSG00000050815
AA Change: V149A

DomainStartEndE-ValueType
Pfam:7tm_4 32 309 2.7e-52 PFAM
Pfam:7tm_1 42 313 5e-19 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000214153
AA Change: V149A

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
Predicted Effect probably benign
Transcript: ENSMUST00000216506
AA Change: V149A

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 34 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Akap13 A G 7: 75,570,019 T57A probably damaging Het
Akna G T 4: 63,379,159 T886N probably benign Het
Aqp9 A G 9: 71,138,213 V38A probably benign Het
Awat2 C T X: 100,404,254 G124D probably damaging Het
Camsap1 A G 2: 25,945,281 probably benign Het
Catsperg2 T C 7: 29,710,133 Y545C probably damaging Het
Cldn23 A G 8: 35,825,920 F138S possibly damaging Het
Clec4a3 A C 6: 122,952,860 probably benign Het
Dlgap3 C A 4: 127,233,897 T786K probably benign Het
Dnah2 A C 11: 69,544,395 S50A probably benign Het
Dnah2 A T 11: 69,520,941 I285N probably damaging Het
Dnah7a A G 1: 53,547,292 Y1467H probably damaging Het
Fgf22 C T 10: 79,756,754 P115L probably damaging Het
Fzd2 G T 11: 102,605,782 V351L possibly damaging Het
Gapdhs T A 7: 30,736,637 E174V possibly damaging Het
Gjc2 A C 11: 59,177,518 I46S probably damaging Het
Gm5581 T C 6: 131,167,772 noncoding transcript Het
Krt2 C A 15: 101,816,330 V282L possibly damaging Het
Myh15 G A 16: 49,195,579 V1873M probably benign Het
Myo1b T C 1: 51,760,377 T931A probably damaging Het
Myo6 A T 9: 80,289,893 K965N unknown Het
Pcnx3 T C 19: 5,686,630 R160G probably benign Het
Slc22a16 T C 10: 40,585,018 I272T probably damaging Het
Slc35b4 A G 6: 34,167,675 Y82H possibly damaging Het
Spdya T C 17: 71,556,259 M1T probably null Het
St6gal1 A G 16: 23,321,424 N115S probably benign Het
Tbc1d12 A T 19: 38,914,300 probably benign Het
Tfrc A G 16: 32,624,443 probably benign Het
Trip11 A C 12: 101,878,862 F1539C probably damaging Het
Ttn A T 2: 76,781,078 I15624N possibly damaging Het
Vmn1r169 A T 7: 23,577,800 M206L probably benign Het
Zfp362 A G 4: 128,787,109 L141P probably damaging Het
Zfp692 A G 11: 58,311,553 H378R probably damaging Het
Zfp799 T C 17: 32,821,820 Q52R possibly damaging Het
Other mutations in Olfr1441
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01446:Olfr1441 APN 19 12422801 missense possibly damaging 0.91
IGL01653:Olfr1441 APN 19 12422372 missense probably benign
IGL01903:Olfr1441 APN 19 12422683 missense probably benign 0.00
IGL02547:Olfr1441 APN 19 12422311 start codon destroyed probably benign 0.38
IGL02571:Olfr1441 APN 19 12422886 missense possibly damaging 0.79
IGL03310:Olfr1441 APN 19 12422927 missense probably benign
R0539:Olfr1441 UTSW 19 12422809 missense probably damaging 0.97
R0918:Olfr1441 UTSW 19 12423235 missense probably benign 0.25
R1463:Olfr1441 UTSW 19 12422888 missense probably benign 0.41
R4301:Olfr1441 UTSW 19 12422717 missense probably damaging 0.98
R4785:Olfr1441 UTSW 19 12422977 missense probably damaging 0.99
R5513:Olfr1441 UTSW 19 12422683 missense probably benign 0.00
R6188:Olfr1441 UTSW 19 12422610 missense probably benign 0.01
R6411:Olfr1441 UTSW 19 12422986 missense probably benign 0.08
R6625:Olfr1441 UTSW 19 12422841 missense probably damaging 1.00
R6944:Olfr1441 UTSW 19 12423264 missense probably benign
R7425:Olfr1441 UTSW 19 12422840 missense probably damaging 1.00
R7465:Olfr1441 UTSW 19 12423145 missense probably damaging 1.00
Posted On2014-01-21