Mutagenetix > Incidental Mutations

Incidental Mutation 'IGL01667:Zfp362'

103346

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Zfp362

Ensembl Gene

ENSMUSG00000028799

Gene Name

zinc finger protein 362

Synonyms

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.229) question?

Stock #

IGL01667

Quality Score

Status

Chromosome

Chromosomal Location

128773088-128806045 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 128787109 bp

Zygosity

Heterozygous

Amino Acid Change

Leucine to Proline at position 141 (L141P)

Ref Sequence

ENSEMBL: ENSMUSP00000128499 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000071108] [ENSMUST00000106072] [ENSMUST00000170934]

Predicted Effect

probably benign
Transcript: ENSMUST00000071108
AA Change: L154P

PolyPhen 2 Score 0.012 (Sensitivity: 0.96; Specificity: 0.78)

SMART Domains

Protein: ENSMUSP00000065733
Gene: ENSMUSG00000028799
AA Change: L154P

Domain	Start	End	E-Value	Type
low complexity region	1	14	N/A	INTRINSIC
low complexity region	128	150	N/A	INTRINSIC
low complexity region	200	211	N/A	INTRINSIC
ZnF_C2H2	225	247	2.75e-3	SMART
ZnF_C2H2	253	275	1.98e-4	SMART
ZnF_C2H2	281	303	1.38e-3	SMART
ZnF_C2H2	309	333	3.49e-5	SMART
ZnF_C2H2	339	361	1.08e-1	SMART
ZnF_C2H2	369	391	7.26e-3	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000106072
AA Change: L154P

PolyPhen 2 Score 0.012 (Sensitivity: 0.96; Specificity: 0.78)

SMART Domains

Protein: ENSMUSP00000101686
Gene: ENSMUSG00000028799
AA Change: L154P

Domain	Start	End	E-Value	Type
low complexity region	1	14	N/A	INTRINSIC
low complexity region	128	150	N/A	INTRINSIC
low complexity region	200	211	N/A	INTRINSIC
ZnF_C2H2	225	247	2.75e-3	SMART
ZnF_C2H2	253	275	1.98e-4	SMART
ZnF_C2H2	281	303	1.38e-3	SMART
ZnF_C2H2	309	333	3.49e-5	SMART
ZnF_C2H2	339	361	1.08e-1	SMART
ZnF_C2H2	369	391	7.26e-3	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000138371

Predicted Effect

probably damaging
Transcript: ENSMUST00000170934
AA Change: L141P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000128499
Gene: ENSMUSG00000028799
AA Change: L141P

Domain	Start	End	E-Value	Type
low complexity region	115	137	N/A	INTRINSIC
low complexity region	187	198	N/A	INTRINSIC
ZnF_C2H2	212	234	2.75e-3	SMART
ZnF_C2H2	240	262	1.98e-4	SMART
ZnF_C2H2	268	290	1.38e-3	SMART
ZnF_C2H2	296	320	3.49e-5	SMART
ZnF_C2H2	326	348	1.08e-1	SMART

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 34 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Akap13	A	G	7: 75,570,019	T57A	probably damaging	Het
Akna	G	T	4: 63,379,159	T886N	probably benign	Het
Aqp9	A	G	9: 71,138,213	V38A	probably benign	Het
Awat2	C	T	X: 100,404,254	G124D	probably damaging	Het
Camsap1	A	G	2: 25,945,281		probably benign	Het
Catsperg2	T	C	7: 29,710,133	Y545C	probably damaging	Het
Cldn23	A	G	8: 35,825,920	F138S	possibly damaging	Het
Clec4a3	A	C	6: 122,952,860		probably benign	Het
Dlgap3	C	A	4: 127,233,897	T786K	probably benign	Het
Dnah2	A	C	11: 69,544,395	S50A	probably benign	Het
Dnah2	A	T	11: 69,520,941	I285N	probably damaging	Het
Dnah7a	A	G	1: 53,547,292	Y1467H	probably damaging	Het
Fgf22	C	T	10: 79,756,754	P115L	probably damaging	Het
Fzd2	G	T	11: 102,605,782	V351L	possibly damaging	Het
Gapdhs	T	A	7: 30,736,637	E174V	possibly damaging	Het
Gjc2	A	C	11: 59,177,518	I46S	probably damaging	Het
Gm5581	T	C	6: 131,167,772		noncoding transcript	Het
Krt2	C	A	15: 101,816,330	V282L	possibly damaging	Het
Myh15	G	A	16: 49,195,579	V1873M	probably benign	Het
Myo1b	T	C	1: 51,760,377	T931A	probably damaging	Het
Myo6	A	T	9: 80,289,893	K965N	unknown	Het
Olfr1441	T	C	19: 12,422,756	V149A	probably benign	Het
Pcnx3	T	C	19: 5,686,630	R160G	probably benign	Het
Slc22a16	T	C	10: 40,585,018	I272T	probably damaging	Het
Slc35b4	A	G	6: 34,167,675	Y82H	possibly damaging	Het
Spdya	T	C	17: 71,556,259	M1T	probably null	Het
St6gal1	A	G	16: 23,321,424	N115S	probably benign	Het
Tbc1d12	A	T	19: 38,914,300		probably benign	Het
Tfrc	A	G	16: 32,624,443		probably benign	Het
Trip11	A	C	12: 101,878,862	F1539C	probably damaging	Het
Ttn	A	T	2: 76,781,078	I15624N	possibly damaging	Het
Vmn1r169	A	T	7: 23,577,800	M206L	probably benign	Het
Zfp692	A	G	11: 58,311,553	H378R	probably damaging	Het
Zfp799	T	C	17: 32,821,820	Q52R	possibly damaging	Het

Other mutations in Zfp362

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01939:Zfp362	APN	4	128787053	missense	probably benign
Zax	UTSW	4	128790260	missense	possibly damaging	0.71
Zebulon	UTSW	4	128786015	missense	probably damaging	1.00
R1471:Zfp362	UTSW	4	128787200	missense	probably benign
R1892:Zfp362	UTSW	4	128790264	missense	probably benign	0.17
R1901:Zfp362	UTSW	4	128790276	missense	probably damaging	1.00
R2058:Zfp362	UTSW	4	128786987	missense	possibly damaging	0.71
R3739:Zfp362	UTSW	4	128786889	splice site	probably benign
R6772:Zfp362	UTSW	4	128790260	missense	possibly damaging	0.71
R6900:Zfp362	UTSW	4	128786015	missense	probably damaging	1.00
R6901:Zfp362	UTSW	4	128786015	missense	probably damaging	1.00
R7105:Zfp362	UTSW	4	128774526	missense	probably damaging	0.99
R7348:Zfp362	UTSW	4	128777217	missense	possibly damaging	0.88
R7629:Zfp362	UTSW	4	128786055	missense	probably damaging	1.00
R7712:Zfp362	UTSW	4	128777410	missense	probably benign	0.14
R7763:Zfp362	UTSW	4	128787031	missense	probably benign
Z1177:Zfp362	UTSW	4	128774550	missense	probably damaging	0.99

Posted On

2014-01-21