Incidental Mutation 'IGL01667:Zfp362'
ID 103346
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Zfp362
Ensembl Gene ENSMUSG00000028799
Gene Name zinc finger protein 362
Synonyms
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.296) question?
Stock # IGL01667
Quality Score
Status
Chromosome 4
Chromosomal Location 128773088-128806045 bp(-) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) A to G at 128787109 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Leucine to Proline at position 141 (L141P)
Ref Sequence ENSEMBL: ENSMUSP00000128499 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000071108] [ENSMUST00000106072] [ENSMUST00000170934]
AlphaFold B1ASA5
Predicted Effect probably benign
Transcript: ENSMUST00000071108
AA Change: L154P

PolyPhen 2 Score 0.012 (Sensitivity: 0.96; Specificity: 0.78)
SMART Domains Protein: ENSMUSP00000065733
Gene: ENSMUSG00000028799
AA Change: L154P

DomainStartEndE-ValueType
low complexity region 1 14 N/A INTRINSIC
low complexity region 128 150 N/A INTRINSIC
low complexity region 200 211 N/A INTRINSIC
ZnF_C2H2 225 247 2.75e-3 SMART
ZnF_C2H2 253 275 1.98e-4 SMART
ZnF_C2H2 281 303 1.38e-3 SMART
ZnF_C2H2 309 333 3.49e-5 SMART
ZnF_C2H2 339 361 1.08e-1 SMART
ZnF_C2H2 369 391 7.26e-3 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000106072
AA Change: L154P

PolyPhen 2 Score 0.012 (Sensitivity: 0.96; Specificity: 0.78)
SMART Domains Protein: ENSMUSP00000101686
Gene: ENSMUSG00000028799
AA Change: L154P

DomainStartEndE-ValueType
low complexity region 1 14 N/A INTRINSIC
low complexity region 128 150 N/A INTRINSIC
low complexity region 200 211 N/A INTRINSIC
ZnF_C2H2 225 247 2.75e-3 SMART
ZnF_C2H2 253 275 1.98e-4 SMART
ZnF_C2H2 281 303 1.38e-3 SMART
ZnF_C2H2 309 333 3.49e-5 SMART
ZnF_C2H2 339 361 1.08e-1 SMART
ZnF_C2H2 369 391 7.26e-3 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000138371
Predicted Effect probably damaging
Transcript: ENSMUST00000170934
AA Change: L141P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000128499
Gene: ENSMUSG00000028799
AA Change: L141P

DomainStartEndE-ValueType
low complexity region 115 137 N/A INTRINSIC
low complexity region 187 198 N/A INTRINSIC
ZnF_C2H2 212 234 2.75e-3 SMART
ZnF_C2H2 240 262 1.98e-4 SMART
ZnF_C2H2 268 290 1.38e-3 SMART
ZnF_C2H2 296 320 3.49e-5 SMART
ZnF_C2H2 326 348 1.08e-1 SMART
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 34 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Akap13 A G 7: 75,570,019 T57A probably damaging Het
Akna G T 4: 63,379,159 T886N probably benign Het
Aqp9 A G 9: 71,138,213 V38A probably benign Het
Awat2 C T X: 100,404,254 G124D probably damaging Het
Camsap1 A G 2: 25,945,281 probably benign Het
Catsperg2 T C 7: 29,710,133 Y545C probably damaging Het
Cldn23 A G 8: 35,825,920 F138S possibly damaging Het
Clec4a3 A C 6: 122,952,860 probably benign Het
Dlgap3 C A 4: 127,233,897 T786K probably benign Het
Dnah2 A C 11: 69,544,395 S50A probably benign Het
Dnah2 A T 11: 69,520,941 I285N probably damaging Het
Dnah7a A G 1: 53,547,292 Y1467H probably damaging Het
Fgf22 C T 10: 79,756,754 P115L probably damaging Het
Fzd2 G T 11: 102,605,782 V351L possibly damaging Het
Gapdhs T A 7: 30,736,637 E174V possibly damaging Het
Gjc2 A C 11: 59,177,518 I46S probably damaging Het
Gm5581 T C 6: 131,167,772 noncoding transcript Het
Krt2 C A 15: 101,816,330 V282L possibly damaging Het
Myh15 G A 16: 49,195,579 V1873M probably benign Het
Myo1b T C 1: 51,760,377 T931A probably damaging Het
Myo6 A T 9: 80,289,893 K965N unknown Het
Olfr1441 T C 19: 12,422,756 V149A probably benign Het
Pcnx3 T C 19: 5,686,630 R160G probably benign Het
Slc22a16 T C 10: 40,585,018 I272T probably damaging Het
Slc35b4 A G 6: 34,167,675 Y82H possibly damaging Het
Spdya T C 17: 71,556,259 M1T probably null Het
St6gal1 A G 16: 23,321,424 N115S probably benign Het
Tbc1d12 A T 19: 38,914,300 probably benign Het
Tfrc A G 16: 32,624,443 probably benign Het
Trip11 A C 12: 101,878,862 F1539C probably damaging Het
Ttn A T 2: 76,781,078 I15624N possibly damaging Het
Vmn1r169 A T 7: 23,577,800 M206L probably benign Het
Zfp692 A G 11: 58,311,553 H378R probably damaging Het
Zfp799 T C 17: 32,821,820 Q52R possibly damaging Het
Other mutations in Zfp362
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01939:Zfp362 APN 4 128787053 missense probably benign
trek UTSW 4 128785976 missense probably damaging 1.00
Zax UTSW 4 128790260 missense possibly damaging 0.71
Zebulon UTSW 4 128786015 missense probably damaging 1.00
R1471:Zfp362 UTSW 4 128787200 missense probably benign
R1892:Zfp362 UTSW 4 128790264 missense probably benign 0.17
R1901:Zfp362 UTSW 4 128790276 missense probably damaging 1.00
R2058:Zfp362 UTSW 4 128786987 missense possibly damaging 0.71
R3739:Zfp362 UTSW 4 128786889 splice site probably benign
R6772:Zfp362 UTSW 4 128790260 missense possibly damaging 0.71
R6900:Zfp362 UTSW 4 128786015 missense probably damaging 1.00
R6901:Zfp362 UTSW 4 128786015 missense probably damaging 1.00
R7105:Zfp362 UTSW 4 128774526 missense probably damaging 0.99
R7348:Zfp362 UTSW 4 128777217 missense possibly damaging 0.88
R7629:Zfp362 UTSW 4 128786055 missense probably damaging 1.00
R7712:Zfp362 UTSW 4 128777410 missense probably benign 0.14
R7763:Zfp362 UTSW 4 128787031 missense probably benign
R8434:Zfp362 UTSW 4 128785976 missense probably damaging 1.00
R8508:Zfp362 UTSW 4 128774606 missense probably damaging 1.00
R9432:Zfp362 UTSW 4 128777187 missense probably damaging 1.00
R9567:Zfp362 UTSW 4 128794888 start codon destroyed unknown
Z1177:Zfp362 UTSW 4 128774550 missense probably damaging 0.99
Posted On 2014-01-21