Incidental Mutation 'IGL01667:Zfp362'
ID103346
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Zfp362
Ensembl Gene ENSMUSG00000028799
Gene Namezinc finger protein 362
Synonyms
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.229) question?
Stock #IGL01667
Quality Score
Status
Chromosome4
Chromosomal Location128773088-128806045 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to G at 128787109 bp
ZygosityHeterozygous
Amino Acid Change Leucine to Proline at position 141 (L141P)
Ref Sequence ENSEMBL: ENSMUSP00000128499 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000071108] [ENSMUST00000106072] [ENSMUST00000170934]
Predicted Effect probably benign
Transcript: ENSMUST00000071108
AA Change: L154P

PolyPhen 2 Score 0.012 (Sensitivity: 0.96; Specificity: 0.78)
SMART Domains Protein: ENSMUSP00000065733
Gene: ENSMUSG00000028799
AA Change: L154P

DomainStartEndE-ValueType
low complexity region 1 14 N/A INTRINSIC
low complexity region 128 150 N/A INTRINSIC
low complexity region 200 211 N/A INTRINSIC
ZnF_C2H2 225 247 2.75e-3 SMART
ZnF_C2H2 253 275 1.98e-4 SMART
ZnF_C2H2 281 303 1.38e-3 SMART
ZnF_C2H2 309 333 3.49e-5 SMART
ZnF_C2H2 339 361 1.08e-1 SMART
ZnF_C2H2 369 391 7.26e-3 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000106072
AA Change: L154P

PolyPhen 2 Score 0.012 (Sensitivity: 0.96; Specificity: 0.78)
SMART Domains Protein: ENSMUSP00000101686
Gene: ENSMUSG00000028799
AA Change: L154P

DomainStartEndE-ValueType
low complexity region 1 14 N/A INTRINSIC
low complexity region 128 150 N/A INTRINSIC
low complexity region 200 211 N/A INTRINSIC
ZnF_C2H2 225 247 2.75e-3 SMART
ZnF_C2H2 253 275 1.98e-4 SMART
ZnF_C2H2 281 303 1.38e-3 SMART
ZnF_C2H2 309 333 3.49e-5 SMART
ZnF_C2H2 339 361 1.08e-1 SMART
ZnF_C2H2 369 391 7.26e-3 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000138371
Predicted Effect probably damaging
Transcript: ENSMUST00000170934
AA Change: L141P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000128499
Gene: ENSMUSG00000028799
AA Change: L141P

DomainStartEndE-ValueType
low complexity region 115 137 N/A INTRINSIC
low complexity region 187 198 N/A INTRINSIC
ZnF_C2H2 212 234 2.75e-3 SMART
ZnF_C2H2 240 262 1.98e-4 SMART
ZnF_C2H2 268 290 1.38e-3 SMART
ZnF_C2H2 296 320 3.49e-5 SMART
ZnF_C2H2 326 348 1.08e-1 SMART
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 34 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Akap13 A G 7: 75,570,019 T57A probably damaging Het
Akna G T 4: 63,379,159 T886N probably benign Het
Aqp9 A G 9: 71,138,213 V38A probably benign Het
Awat2 C T X: 100,404,254 G124D probably damaging Het
Camsap1 A G 2: 25,945,281 probably benign Het
Catsperg2 T C 7: 29,710,133 Y545C probably damaging Het
Cldn23 A G 8: 35,825,920 F138S possibly damaging Het
Clec4a3 A C 6: 122,952,860 probably benign Het
Dlgap3 C A 4: 127,233,897 T786K probably benign Het
Dnah2 A C 11: 69,544,395 S50A probably benign Het
Dnah2 A T 11: 69,520,941 I285N probably damaging Het
Dnah7a A G 1: 53,547,292 Y1467H probably damaging Het
Fgf22 C T 10: 79,756,754 P115L probably damaging Het
Fzd2 G T 11: 102,605,782 V351L possibly damaging Het
Gapdhs T A 7: 30,736,637 E174V possibly damaging Het
Gjc2 A C 11: 59,177,518 I46S probably damaging Het
Gm5581 T C 6: 131,167,772 noncoding transcript Het
Krt2 C A 15: 101,816,330 V282L possibly damaging Het
Myh15 G A 16: 49,195,579 V1873M probably benign Het
Myo1b T C 1: 51,760,377 T931A probably damaging Het
Myo6 A T 9: 80,289,893 K965N unknown Het
Olfr1441 T C 19: 12,422,756 V149A probably benign Het
Pcnx3 T C 19: 5,686,630 R160G probably benign Het
Slc22a16 T C 10: 40,585,018 I272T probably damaging Het
Slc35b4 A G 6: 34,167,675 Y82H possibly damaging Het
Spdya T C 17: 71,556,259 M1T probably null Het
St6gal1 A G 16: 23,321,424 N115S probably benign Het
Tbc1d12 A T 19: 38,914,300 probably benign Het
Tfrc A G 16: 32,624,443 probably benign Het
Trip11 A C 12: 101,878,862 F1539C probably damaging Het
Ttn A T 2: 76,781,078 I15624N possibly damaging Het
Vmn1r169 A T 7: 23,577,800 M206L probably benign Het
Zfp692 A G 11: 58,311,553 H378R probably damaging Het
Zfp799 T C 17: 32,821,820 Q52R possibly damaging Het
Other mutations in Zfp362
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01939:Zfp362 APN 4 128787053 missense probably benign
Zax UTSW 4 128790260 missense possibly damaging 0.71
Zebulon UTSW 4 128786015 missense probably damaging 1.00
R1471:Zfp362 UTSW 4 128787200 missense probably benign
R1892:Zfp362 UTSW 4 128790264 missense probably benign 0.17
R1901:Zfp362 UTSW 4 128790276 missense probably damaging 1.00
R2058:Zfp362 UTSW 4 128786987 missense possibly damaging 0.71
R3739:Zfp362 UTSW 4 128786889 splice site probably benign
R6772:Zfp362 UTSW 4 128790260 missense possibly damaging 0.71
R6900:Zfp362 UTSW 4 128786015 missense probably damaging 1.00
R6901:Zfp362 UTSW 4 128786015 missense probably damaging 1.00
R7105:Zfp362 UTSW 4 128774526 missense probably damaging 0.99
R7348:Zfp362 UTSW 4 128777217 missense possibly damaging 0.88
R7629:Zfp362 UTSW 4 128786055 missense probably damaging 1.00
R7712:Zfp362 UTSW 4 128777410 missense probably benign 0.14
R7763:Zfp362 UTSW 4 128787031 missense probably benign
Z1177:Zfp362 UTSW 4 128774550 missense probably damaging 0.99
Posted On2014-01-21