Incidental Mutation 'IGL01667:Vmn1r169'
ID103350
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Vmn1r169
Ensembl Gene ENSMUSG00000094602
Gene Namevomeronasal 1 receptor 169
SynonymsGm4232
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.067) question?
Stock #IGL01667
Quality Score
Status
Chromosome7
Chromosomal Location23575526-23578849 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to T at 23577800 bp
ZygosityHeterozygous
Amino Acid Change Methionine to Leucine at position 206 (M206L)
Ref Sequence ENSEMBL: ENSMUSP00000154343 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000170290] [ENSMUST00000226669] [ENSMUST00000227547] [ENSMUST00000227932] [ENSMUST00000228832]
Predicted Effect probably benign
Transcript: ENSMUST00000170290
AA Change: M206L

PolyPhen 2 Score 0.172 (Sensitivity: 0.92; Specificity: 0.87)
SMART Domains Protein: ENSMUSP00000126133
Gene: ENSMUSG00000094602
AA Change: M206L

DomainStartEndE-ValueType
Pfam:TAS2R 8 295 4e-14 PFAM
Pfam:V1R 41 295 2.1e-21 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000226669
AA Change: M206L

PolyPhen 2 Score 0.172 (Sensitivity: 0.92; Specificity: 0.87)
Predicted Effect probably benign
Transcript: ENSMUST00000227547
AA Change: M206L

PolyPhen 2 Score 0.172 (Sensitivity: 0.92; Specificity: 0.87)
Predicted Effect probably benign
Transcript: ENSMUST00000227932
AA Change: M206L

PolyPhen 2 Score 0.172 (Sensitivity: 0.92; Specificity: 0.87)
Predicted Effect probably benign
Transcript: ENSMUST00000228832
AA Change: M206L

PolyPhen 2 Score 0.172 (Sensitivity: 0.92; Specificity: 0.87)
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 34 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Akap13 A G 7: 75,570,019 T57A probably damaging Het
Akna G T 4: 63,379,159 T886N probably benign Het
Aqp9 A G 9: 71,138,213 V38A probably benign Het
Awat2 C T X: 100,404,254 G124D probably damaging Het
Camsap1 A G 2: 25,945,281 probably benign Het
Catsperg2 T C 7: 29,710,133 Y545C probably damaging Het
Cldn23 A G 8: 35,825,920 F138S possibly damaging Het
Clec4a3 A C 6: 122,952,860 probably benign Het
Dlgap3 C A 4: 127,233,897 T786K probably benign Het
Dnah2 A C 11: 69,544,395 S50A probably benign Het
Dnah2 A T 11: 69,520,941 I285N probably damaging Het
Dnah7a A G 1: 53,547,292 Y1467H probably damaging Het
Fgf22 C T 10: 79,756,754 P115L probably damaging Het
Fzd2 G T 11: 102,605,782 V351L possibly damaging Het
Gapdhs T A 7: 30,736,637 E174V possibly damaging Het
Gjc2 A C 11: 59,177,518 I46S probably damaging Het
Gm5581 T C 6: 131,167,772 noncoding transcript Het
Krt2 C A 15: 101,816,330 V282L possibly damaging Het
Myh15 G A 16: 49,195,579 V1873M probably benign Het
Myo1b T C 1: 51,760,377 T931A probably damaging Het
Myo6 A T 9: 80,289,893 K965N unknown Het
Olfr1441 T C 19: 12,422,756 V149A probably benign Het
Pcnx3 T C 19: 5,686,630 R160G probably benign Het
Slc22a16 T C 10: 40,585,018 I272T probably damaging Het
Slc35b4 A G 6: 34,167,675 Y82H possibly damaging Het
Spdya T C 17: 71,556,259 M1T probably null Het
St6gal1 A G 16: 23,321,424 N115S probably benign Het
Tbc1d12 A T 19: 38,914,300 probably benign Het
Tfrc A G 16: 32,624,443 probably benign Het
Trip11 A C 12: 101,878,862 F1539C probably damaging Het
Ttn A T 2: 76,781,078 I15624N possibly damaging Het
Zfp362 A G 4: 128,787,109 L141P probably damaging Het
Zfp692 A G 11: 58,311,553 H378R probably damaging Het
Zfp799 T C 17: 32,821,820 Q52R possibly damaging Het
Other mutations in Vmn1r169
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00897:Vmn1r169 APN 7 23577594 missense probably damaging 1.00
IGL01019:Vmn1r169 APN 7 23577186 start codon destroyed probably null 0.99
IGL02246:Vmn1r169 APN 7 23577236 missense probably benign 0.09
IGL03303:Vmn1r169 APN 7 23578009 missense probably benign 0.40
R1345:Vmn1r169 UTSW 7 23577822 missense probably damaging 1.00
R6471:Vmn1r169 UTSW 7 23577545 missense probably benign 0.25
R7120:Vmn1r169 UTSW 7 23578019 missense probably benign 0.00
R7268:Vmn1r169 UTSW 7 23577428 missense probably benign 0.00
R7541:Vmn1r169 UTSW 7 23577987 missense probably benign 0.04
Posted On2014-01-21