Incidental Mutation 'IGL01669:Ceacam18'
ID103402
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Ceacam18
Ensembl Gene ENSMUSG00000030472
Gene Namecarcinoembryonic antigen-related cell adhesion molecule 18
Synonyms2010110O04Rik
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.062) question?
Stock #IGL01669
Quality Score
Status
Chromosome7
Chromosomal Location43634707-43649295 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) G to A at 43645515 bp
ZygosityHeterozygous
Amino Acid Change Glycine to Glutamic Acid at position 333 (G333E)
Ref Sequence ENSEMBL: ENSMUSP00000032663 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000032663]
Predicted Effect probably damaging
Transcript: ENSMUST00000032663
AA Change: G333E

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000032663
Gene: ENSMUSG00000030472
AA Change: G333E

DomainStartEndE-ValueType
signal peptide 1 28 N/A INTRINSIC
IG_like 36 135 1.03e2 SMART
IG_like 148 226 5.56e0 SMART
IGc2 248 305 5.24e-7 SMART
transmembrane domain 334 356 N/A INTRINSIC
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 40 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acsl4 G T X: 142,343,188 D313E probably damaging Het
Aifm3 A C 16: 17,503,541 K453T probably benign Het
Anks1b T C 10: 90,897,238 probably benign Het
Arfgef1 T C 1: 10,159,615 D1287G probably damaging Het
Bcl3 G A 7: 19,812,491 Q140* probably null Het
Bnipl T G 3: 95,242,734 R316S probably damaging Het
Cacna1i T A 15: 80,391,757 H1916Q probably benign Het
Ccdc171 C T 4: 83,681,195 A749V probably damaging Het
Cul7 G T 17: 46,658,715 M969I possibly damaging Het
Cylc2 A G 4: 51,228,360 T144A probably benign Het
Cyp2c50 A T 19: 40,098,051 H294L probably damaging Het
D430041D05Rik T C 2: 104,254,961 K1081R probably damaging Het
D930020B18Rik A G 10: 121,683,961 K456R probably benign Het
Drd2 A G 9: 49,402,089 N186S possibly damaging Het
Fanci A T 7: 79,449,177 E1306D probably benign Het
Fbxl21 T A 13: 56,527,709 probably benign Het
Galk2 T A 2: 125,887,887 Y63N probably damaging Het
Git2 T C 5: 114,767,105 D97G probably damaging Het
Gm8258 T A 5: 104,776,074 noncoding transcript Het
Irf4 G T 13: 30,757,471 S270I probably damaging Het
Itgb3 C A 11: 104,633,390 probably benign Het
Itpr2 A C 6: 146,180,229 I2299R probably damaging Het
Lig4 T C 8: 9,973,673 I36V probably benign Het
Nedd9 A G 13: 41,338,635 V133A probably damaging Het
Nup133 A C 8: 123,939,130 Y185* probably null Het
Olfr1162 T C 2: 88,049,784 Y280C possibly damaging Het
Olfr623 A T 7: 103,660,987 F88I probably benign Het
Olfr788 A G 10: 129,473,211 H173R probably damaging Het
Pgbd5 T A 8: 124,374,399 T373S possibly damaging Het
Ppp1r8 T C 4: 132,828,169 E246G probably benign Het
Rmnd5b C T 11: 51,627,900 V89M probably damaging Het
Rnf123 T C 9: 108,058,356 I969V probably damaging Het
Ror2 A G 13: 53,111,088 I656T probably damaging Het
Sgsm1 T C 5: 113,263,490 E503G probably benign Het
Smgc T A 15: 91,860,684 S381T possibly damaging Het
Tlr4 T G 4: 66,841,267 F766V possibly damaging Het
Tnc T C 4: 64,000,701 T1162A probably damaging Het
Usp39 A G 6: 72,338,493 V156A probably damaging Het
Zdhhc5 A G 2: 84,691,194 Y352H probably damaging Het
Zfp646 A G 7: 127,878,965 T105A probably benign Het
Other mutations in Ceacam18
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00426:Ceacam18 APN 7 43639356 missense probably benign 0.00
IGL00585:Ceacam18 APN 7 43637011 missense possibly damaging 0.90
R0001:Ceacam18 UTSW 7 43636876 missense possibly damaging 0.58
R0227:Ceacam18 UTSW 7 43639391 missense probably damaging 1.00
R1524:Ceacam18 UTSW 7 43639355 missense possibly damaging 0.95
R1647:Ceacam18 UTSW 7 43639265 missense possibly damaging 0.78
R1768:Ceacam18 UTSW 7 43648494 missense probably benign 0.00
R1828:Ceacam18 UTSW 7 43639456 missense probably benign 0.19
R3751:Ceacam18 UTSW 7 43641948 missense probably damaging 1.00
R4870:Ceacam18 UTSW 7 43641904 missense probably damaging 1.00
R5259:Ceacam18 UTSW 7 43637112 critical splice donor site probably null
R5358:Ceacam18 UTSW 7 43637073 missense possibly damaging 0.57
R5368:Ceacam18 UTSW 7 43642034 missense probably benign 0.08
R5810:Ceacam18 UTSW 7 43636958 missense probably benign 0.00
R5817:Ceacam18 UTSW 7 43641841 missense probably benign 0.07
R5835:Ceacam18 UTSW 7 43636958 missense probably benign 0.00
R7113:Ceacam18 UTSW 7 43641976 missense probably benign
R7138:Ceacam18 UTSW 7 43639282 missense possibly damaging 0.80
R7275:Ceacam18 UTSW 7 43641884 missense probably damaging 1.00
R7502:Ceacam18 UTSW 7 43636874 missense probably damaging 0.99
Posted On2014-01-21