Incidental Mutation 'IGL01670:Or5w18'
ID 103445
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Or5w18
Ensembl Gene ENSMUSG00000068815
Gene Name olfactory receptor family 5 subfamily W member 18
Synonyms MOR177-14, Olfr1143, GA_x6K02T2Q125-49303473-49304405
Accession Numbers
Essential gene? Probably non essential (E-score: 0.144) question?
Stock # IGL01670
Quality Score
Status
Chromosome 2
Chromosomal Location 87632735-87633679 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 87633224 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Alanine at position 164 (T164A)
Ref Sequence ENSEMBL: ENSMUSP00000088210 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000090708] [ENSMUST00000099852] [ENSMUST00000111568]
AlphaFold Q8VEU8
Predicted Effect probably benign
Transcript: ENSMUST00000090708
AA Change: T164A

PolyPhen 2 Score 0.101 (Sensitivity: 0.93; Specificity: 0.86)
SMART Domains Protein: ENSMUSP00000088210
Gene: ENSMUSG00000068815
AA Change: T164A

DomainStartEndE-ValueType
Pfam:7tm_4 35 312 2.6e-45 PFAM
Pfam:7tm_1 45 294 5.8e-20 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000099852
AA Change: T160A

PolyPhen 2 Score 0.083 (Sensitivity: 0.93; Specificity: 0.85)
SMART Domains Protein: ENSMUSP00000097438
Gene: ENSMUSG00000068815
AA Change: T160A

DomainStartEndE-ValueType
Pfam:7tm_4 31 307 2e-41 PFAM
Pfam:7tm_1 41 290 4.3e-14 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000111568
AA Change: T160A

PolyPhen 2 Score 0.083 (Sensitivity: 0.93; Specificity: 0.85)
SMART Domains Protein: ENSMUSP00000107194
Gene: ENSMUSG00000068815
AA Change: T160A

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 1.5e-44 PFAM
Pfam:7tm_1 41 290 2.8e-16 PFAM
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 46 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acy1 A C 9: 106,314,006 (GRCm39) probably benign Het
Add1 C A 5: 34,777,407 (GRCm39) Q57K probably damaging Het
Alms1 A G 6: 85,655,132 (GRCm39) E3226G probably benign Het
Arl1 G T 10: 88,577,884 (GRCm39) R151L probably damaging Het
Cabs1 T A 5: 88,127,869 (GRCm39) D173E possibly damaging Het
Cdc34b T C 11: 94,632,845 (GRCm39) L15P probably benign Het
Cdyl2 A G 8: 117,351,092 (GRCm39) V13A probably damaging Het
Chd7 G T 4: 8,827,033 (GRCm39) R1026L probably damaging Het
Cldn34b4 T C X: 75,441,195 (GRCm39) S151P probably damaging Het
Col14a1 T A 15: 55,192,662 (GRCm39) I25N unknown Het
Crisp4 T A 1: 18,198,901 (GRCm39) T178S probably benign Het
Csmd2 C T 4: 128,407,164 (GRCm39) probably benign Het
Csmd3 T G 15: 47,475,225 (GRCm39) N2454H probably damaging Het
Cytip A T 2: 58,023,785 (GRCm39) I345N probably damaging Het
Frem2 A T 3: 53,564,358 (GRCm39) S50T possibly damaging Het
Gm9747 C T 1: 82,211,870 (GRCm39) probably benign Het
Gpr37 A G 6: 25,669,833 (GRCm39) F337S probably damaging Het
Herc1 A G 9: 66,394,342 (GRCm39) E4182G probably damaging Het
Isyna1 C T 8: 71,049,706 (GRCm39) P511L probably benign Het
Kdm4a T C 4: 118,017,698 (GRCm39) Y456C probably damaging Het
Kera A T 10: 97,444,939 (GRCm39) R99S possibly damaging Het
Larp7-ps T C 4: 92,079,737 (GRCm39) probably null Het
Mcm2 A G 6: 88,864,614 (GRCm39) probably benign Het
Myl12a T C 17: 71,303,848 (GRCm39) T10A probably benign Het
Nav3 A G 10: 109,550,102 (GRCm39) V1876A possibly damaging Het
Nkx6-1 T A 5: 101,809,806 (GRCm39) Q247L probably benign Het
Nol8 A C 13: 49,814,784 (GRCm39) K297N possibly damaging Het
Or4c119 T A 2: 88,987,261 (GRCm39) Y86F probably benign Het
Or51e1 A T 7: 102,358,772 (GRCm39) Q102L probably damaging Het
Pard3b A T 1: 62,250,807 (GRCm39) N579Y probably damaging Het
Pdcd11 T A 19: 47,094,743 (GRCm39) L509H probably damaging Het
Prss29 T C 17: 25,541,437 (GRCm39) S266P probably benign Het
Rapgef3 G T 15: 97,647,543 (GRCm39) H766N probably benign Het
Rasa1 A T 13: 85,373,609 (GRCm39) S818T probably damaging Het
Rtn4ip1 A G 10: 43,804,322 (GRCm39) M1V probably null Het
Sall1 A T 8: 89,758,199 (GRCm39) V635D probably benign Het
Slc35b4 C T 6: 34,147,484 (GRCm39) V35I probably benign Het
Slc5a11 G A 7: 122,869,172 (GRCm39) A587T probably benign Het
Slc6a21 T C 7: 44,937,557 (GRCm39) V616A possibly damaging Het
Sorl1 A G 9: 41,912,788 (GRCm39) S1398P possibly damaging Het
Srcap A G 7: 127,127,604 (GRCm39) K390E probably damaging Het
Sycp2 C T 2: 178,019,843 (GRCm39) E558K probably benign Het
Tcf20 T C 15: 82,739,564 (GRCm39) N629S possibly damaging Het
Tmem154 A G 3: 84,591,537 (GRCm39) Y29C probably damaging Het
Tmtc3 A G 10: 100,282,987 (GRCm39) I856T probably benign Het
Zswim6 A G 13: 107,865,101 (GRCm39) noncoding transcript Het
Other mutations in Or5w18
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01086:Or5w18 APN 2 87,633,544 (GRCm39) nonsense probably null
IGL02503:Or5w18 APN 2 87,632,864 (GRCm39) missense probably benign 0.01
R0316:Or5w18 UTSW 2 87,633,525 (GRCm39) missense probably damaging 0.98
R1381:Or5w18 UTSW 2 87,633,480 (GRCm39) missense probably damaging 1.00
R1496:Or5w18 UTSW 2 87,633,212 (GRCm39) missense probably benign 0.00
R1753:Or5w18 UTSW 2 87,633,106 (GRCm39) missense probably benign 0.06
R2013:Or5w18 UTSW 2 87,632,847 (GRCm39) missense probably damaging 0.97
R2370:Or5w18 UTSW 2 87,633,159 (GRCm39) missense probably benign 0.35
R3810:Or5w18 UTSW 2 87,633,396 (GRCm39) missense possibly damaging 0.90
R3812:Or5w18 UTSW 2 87,633,396 (GRCm39) missense possibly damaging 0.90
R3909:Or5w18 UTSW 2 87,633,031 (GRCm39) missense probably benign
R4227:Or5w18 UTSW 2 87,633,219 (GRCm39) missense probably damaging 0.97
R5753:Or5w18 UTSW 2 87,633,596 (GRCm39) missense probably benign 0.05
R6516:Or5w18 UTSW 2 87,633,114 (GRCm39) missense possibly damaging 0.81
R9101:Or5w18 UTSW 2 87,632,924 (GRCm39) missense probably damaging 1.00
R9144:Or5w18 UTSW 2 87,633,482 (GRCm39) missense probably benign 0.02
Z1177:Or5w18 UTSW 2 87,633,572 (GRCm39) missense probably damaging 1.00
Posted On 2014-01-21