Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01670:Tmem154'

103447

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Tmem154

Ensembl Gene

ENSMUSG00000056498

Gene Name

transmembrane protein 154

Synonyms

9930117H01Rik

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.056) question?

Stock #

IGL01670

Quality Score

Status

Chromosome

Chromosomal Location

84666192-84704575 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 84684230 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Tyrosine to Cysteine at position 29 (Y29C)

Ref Sequence

ENSEMBL: ENSMUSP00000103310 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000107682] [ENSMUST00000154148]

AlphaFold

Q8C4Q9

Predicted Effect

probably damaging
Transcript: ENSMUST00000107682
AA Change: Y29C

PolyPhen 2 Score 0.983 (Sensitivity: 0.75; Specificity: 0.96)

SMART Domains

Protein: ENSMUSP00000103310
Gene: ENSMUSG00000056498
AA Change: Y29C

Domain	Start	End	E-Value	Type
signal peptide	1	22	N/A	INTRINSIC
Pfam:TMEM154	24	163	6.2e-52	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000129417

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000134890

Predicted Effect

probably benign
Transcript: ENSMUST00000154148

SMART Domains

Protein: ENSMUSP00000116393
Gene: ENSMUSG00000102805

Domain	Start	End	E-Value	Type
Arfaptin	1	227	7.15e-121	SMART

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 46 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Acy1	A	C	9: 106,436,807		probably benign	Het
Add1	C	A	5: 34,620,063	Q57K	probably damaging	Het
Alms1	A	G	6: 85,678,150	E3226G	probably benign	Het
Arl1	G	T	10: 88,742,022	R151L	probably damaging	Het
Cabs1	T	A	5: 87,980,010	D173E	possibly damaging	Het
Cdc34b	T	C	11: 94,742,019	L15P	probably benign	Het
Cdyl2	A	G	8: 116,624,353	V13A	probably damaging	Het
Chd7	G	T	4: 8,827,033	R1026L	probably damaging	Het
Cldn34b4	T	C	X: 76,397,589	S151P	probably damaging	Het
Col14a1	T	A	15: 55,329,266	I25N	unknown	Het
Crisp4	T	A	1: 18,128,677	T178S	probably benign	Het
Csmd2	C	T	4: 128,513,371		probably benign	Het
Csmd3	T	G	15: 47,611,829	N2454H	probably damaging	Het
Cytip	A	T	2: 58,133,773	I345N	probably damaging	Het
Frem2	A	T	3: 53,656,937	S50T	possibly damaging	Het
Gm12666	T	C	4: 92,191,500		probably null	Het
Gm9747	C	T	1: 82,234,149		probably benign	Het
Gpr37	A	G	6: 25,669,834	F337S	probably damaging	Het
Herc1	A	G	9: 66,487,060	E4182G	probably damaging	Het
Isyna1	C	T	8: 70,597,056	P511L	probably benign	Het
Kdm4a	T	C	4: 118,160,501	Y456C	probably damaging	Het
Kera	A	T	10: 97,609,077	R99S	possibly damaging	Het
Mcm2	A	G	6: 88,887,632		probably benign	Het
Myl12a	T	C	17: 70,996,853	T10A	probably benign	Het
Nav3	A	G	10: 109,714,241	V1876A	possibly damaging	Het
Nkx6-1	T	A	5: 101,661,940	Q247L	probably benign	Het
Nol8	A	C	13: 49,661,308	K297N	possibly damaging	Het
Olfr1143	A	G	2: 87,802,880	T164A	probably benign	Het
Olfr1224-ps1	T	A	2: 89,156,917	Y86F	probably benign	Het
Olfr558	A	T	7: 102,709,565	Q102L	probably damaging	Het
Pard3b	A	T	1: 62,211,648	N579Y	probably damaging	Het
Pdcd11	T	A	19: 47,106,304	L509H	probably damaging	Het
Prss29	T	C	17: 25,322,463	S266P	probably benign	Het
Rapgef3	G	T	15: 97,749,662	H766N	probably benign	Het
Rasa1	A	T	13: 85,225,490	S818T	probably damaging	Het
Rtn4ip1	A	G	10: 43,928,326	M1V	probably null	Het
Sall1	A	T	8: 89,031,571	V635D	probably benign	Het
Slc35b4	C	T	6: 34,170,549	V35I	probably benign	Het
Slc5a11	G	A	7: 123,269,949	A587T	probably benign	Het
Slc6a21	T	C	7: 45,288,133	V616A	possibly damaging	Het
Sorl1	A	G	9: 42,001,492	S1398P	possibly damaging	Het
Srcap	A	G	7: 127,528,432	K390E	probably damaging	Het
Sycp2	C	T	2: 178,378,050	E558K	probably benign	Het
Tcf20	T	C	15: 82,855,363	N629S	possibly damaging	Het
Tmtc3	A	G	10: 100,447,125	I856T	probably benign	Het
Zswim6	A	G	13: 107,728,566		noncoding transcript	Het

Other mutations in Tmem154

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00331:Tmem154	APN	3	84684415	missense	probably benign	0.05
IGL01516:Tmem154	APN	3	84684590	missense	probably benign
IGL02955:Tmem154	APN	3	84684201	intron	probably benign
IGL03406:Tmem154	APN	3	84684260	missense	probably benign	0.00
R6245:Tmem154	UTSW	3	84684296	missense	possibly damaging	0.83
R6885:Tmem154	UTSW	3	84692506	missense	possibly damaging	0.95
R7287:Tmem154	UTSW	3	84690563	missense	possibly damaging	0.95
R9748:Tmem154	UTSW	3	84666386	missense	possibly damaging	0.96

Posted On

2014-01-21