Incidental Mutation 'IGL01672:Or5p1'
ID 103504
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Or5p1
Ensembl Gene ENSMUSG00000094612
Gene Name olfactory receptor family 5 subfamily P member 1
Synonyms MOR204-11, GA_x6K02T2PBJ9-10646917-10647849, Olfr491
Accession Numbers
Essential gene? Probably non essential (E-score: 0.097) question?
Stock # IGL01672
Quality Score
Status
Chromosome 7
Chromosomal Location 107916103-107917035 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 107916725 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Glutamic Acid at position 208 (V208E)
Ref Sequence ENSEMBL: ENSMUSP00000150694 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000053179] [ENSMUST00000209545] [ENSMUST00000214605]
AlphaFold Q8VG06
Predicted Effect probably benign
Transcript: ENSMUST00000053179
AA Change: V208E

PolyPhen 2 Score 0.020 (Sensitivity: 0.95; Specificity: 0.80)
SMART Domains Protein: ENSMUSP00000061188
Gene: ENSMUSG00000094612
AA Change: V208E

DomainStartEndE-ValueType
Pfam:7tm_4 31 307 3.4e-50 PFAM
Pfam:7tm_1 41 290 5.4e-20 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000209545
AA Change: V208E

PolyPhen 2 Score 0.020 (Sensitivity: 0.95; Specificity: 0.80)
Predicted Effect probably benign
Transcript: ENSMUST00000214605
AA Change: V208E

PolyPhen 2 Score 0.020 (Sensitivity: 0.95; Specificity: 0.80)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 46 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A2m A G 6: 121,618,316 (GRCm39) E203G probably damaging Het
Ano1 G T 7: 144,209,412 (GRCm39) Q206K probably damaging Het
Ap4e1 T A 2: 126,894,109 (GRCm39) S620T probably damaging Het
Arfip1 A T 3: 84,455,339 (GRCm39) probably benign Het
Atp8a2 A T 14: 59,928,982 (GRCm39) M1024K probably benign Het
Brap T C 5: 121,816,908 (GRCm39) probably benign Het
Calcrl T A 2: 84,175,414 (GRCm39) T287S probably damaging Het
Clptm1l G A 13: 73,755,992 (GRCm39) probably null Het
Cpb1 T A 3: 20,329,585 (GRCm39) Q47L probably null Het
Cse1l T C 2: 166,771,887 (GRCm39) I402T probably damaging Het
Dnah17 A G 11: 117,932,986 (GRCm39) S3591P probably damaging Het
Dst T G 1: 34,264,774 (GRCm39) I2322S probably damaging Het
Dync2h1 G A 9: 7,118,884 (GRCm39) R2194* probably null Het
Ecpas A G 4: 58,814,041 (GRCm39) V1355A probably benign Het
Eno4 A G 19: 58,931,977 (GRCm39) N30S possibly damaging Het
Ero1a A C 14: 45,529,887 (GRCm39) S349A probably benign Het
Fat1 C T 8: 45,493,737 (GRCm39) T3938I probably benign Het
Focad T C 4: 88,278,827 (GRCm39) probably null Het
Gnai3 A T 3: 108,016,775 (GRCm39) I343N probably damaging Het
Golph3 T C 15: 12,349,643 (GRCm39) V221A probably benign Het
Gpr153 C A 4: 152,364,370 (GRCm39) S142* probably null Het
Itpr1 C A 6: 108,357,993 (GRCm39) Y557* probably null Het
Nat8f5 A G 6: 85,794,934 (GRCm39) Y9H probably damaging Het
Nbas T C 12: 13,429,650 (GRCm39) V1045A possibly damaging Het
Nol8 T C 13: 49,828,883 (GRCm39) V1047A possibly damaging Het
Or2t48 A C 11: 58,419,948 (GRCm39) L288R probably benign Het
Osbpl1a G A 18: 12,899,881 (GRCm39) T178I probably damaging Het
Palld T A 8: 62,330,536 (GRCm39) I114F probably benign Het
Pcca A T 14: 122,927,557 (GRCm39) Y440F probably benign Het
Pclo T C 5: 14,728,549 (GRCm39) probably benign Het
Piwil1 T C 5: 128,827,037 (GRCm39) M599T possibly damaging Het
Pkd1l2 T A 8: 117,807,471 (GRCm39) Y189F possibly damaging Het
Plscr3 A G 11: 69,738,508 (GRCm39) K91R possibly damaging Het
Rars1 A T 11: 35,699,380 (GRCm39) C638S probably damaging Het
Relb T A 7: 19,345,619 (GRCm39) H406L probably benign Het
Ros1 G T 10: 51,977,899 (GRCm39) T1449K possibly damaging Het
Samd3 A T 10: 26,146,067 (GRCm39) N364I possibly damaging Het
Scn2a T A 2: 65,582,278 (GRCm39) I1542N probably damaging Het
Sdk1 T A 5: 142,170,930 (GRCm39) M1931K probably benign Het
Sphk2 T C 7: 45,361,077 (GRCm39) D309G possibly damaging Het
Stil T C 4: 114,889,986 (GRCm39) S825P probably damaging Het
Swt1 C T 1: 151,270,359 (GRCm39) probably null Het
Virma C T 4: 11,527,792 (GRCm39) R1228C probably damaging Het
Xirp2 T A 2: 67,338,846 (GRCm39) H362Q probably benign Het
Zfp451 C A 1: 33,801,247 (GRCm39) M1056I probably benign Het
Zfp458 T A 13: 67,405,300 (GRCm39) M380L probably benign Het
Other mutations in Or5p1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01731:Or5p1 APN 7 107,916,682 (GRCm39) missense probably benign 0.01
IGL02227:Or5p1 APN 7 107,916,408 (GRCm39) nonsense probably null
IGL02624:Or5p1 APN 7 107,916,130 (GRCm39) missense probably benign 0.38
IGL03164:Or5p1 APN 7 107,916,901 (GRCm39) missense probably damaging 1.00
R0143:Or5p1 UTSW 7 107,916,202 (GRCm39) missense probably benign 0.00
R0217:Or5p1 UTSW 7 107,916,505 (GRCm39) missense probably benign 0.00
R0295:Or5p1 UTSW 7 107,916,892 (GRCm39) missense probably benign 0.42
R2100:Or5p1 UTSW 7 107,916,761 (GRCm39) missense probably benign 0.04
R2379:Or5p1 UTSW 7 107,916,499 (GRCm39) missense probably benign 0.25
R4178:Or5p1 UTSW 7 107,916,565 (GRCm39) missense probably damaging 1.00
R4365:Or5p1 UTSW 7 107,916,313 (GRCm39) missense probably benign 0.02
R4734:Or5p1 UTSW 7 107,916,959 (GRCm39) missense probably damaging 1.00
R4828:Or5p1 UTSW 7 107,916,677 (GRCm39) missense probably benign 0.00
R6424:Or5p1 UTSW 7 107,916,412 (GRCm39) missense probably benign 0.01
R6784:Or5p1 UTSW 7 107,916,989 (GRCm39) missense probably damaging 0.98
R7109:Or5p1 UTSW 7 107,916,959 (GRCm39) missense probably damaging 1.00
R7348:Or5p1 UTSW 7 107,916,920 (GRCm39) missense possibly damaging 0.58
R7590:Or5p1 UTSW 7 107,916,386 (GRCm39) missense probably benign 0.00
R8124:Or5p1 UTSW 7 107,916,984 (GRCm39) missense possibly damaging 0.48
R8782:Or5p1 UTSW 7 107,916,296 (GRCm39) missense probably damaging 0.99
X0060:Or5p1 UTSW 7 107,916,427 (GRCm39) missense probably benign 0.06
Posted On 2014-01-21