Incidental Mutation 'IGL00674:Prl3d3'
| ID |
10352 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Prl3d3
|
| Ensembl Gene |
ENSMUSG00000062201 |
| Gene Name |
prolactin family 3, subfamily d, member 3 |
| Synonyms |
Plig, PL-Ig |
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.057)
|
| Stock # |
IGL00674
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
13 |
| Chromosomal Location |
27340777-27346576 bp(+) (GRCm39) |
| Type of Mutation |
critical splice donor site (2 bp from exon) |
| DNA Base Change (assembly) |
T to C
at 27343114 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000153035
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000073601]
[ENSMUST00000223958]
|
| AlphaFold |
A0A0M6L0J6 |
| Predicted Effect |
probably null
Transcript: ENSMUST00000073601
|
| SMART Domains |
Protein: ENSMUSP00000073286
Gene: ENSMUSG00000062201
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Hormone_1
|
16 |
223 |
9.9e-72 |
PFAM |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000223958
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 19 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Atad2 |
T |
A |
15: 57,971,782 (GRCm39) |
Q365L |
possibly damaging |
Het |
| Cd2ap |
A |
T |
17: 43,119,676 (GRCm39) |
N492K |
probably benign |
Het |
| Fam114a1 |
T |
A |
5: 65,137,347 (GRCm39) |
S97T |
probably benign |
Het |
| Fbxw8 |
C |
T |
5: 118,233,658 (GRCm39) |
M324I |
possibly damaging |
Het |
| Gpx6 |
A |
G |
13: 21,497,978 (GRCm39) |
|
probably benign |
Het |
| Kbtbd3 |
A |
G |
9: 4,329,949 (GRCm39) |
T108A |
probably benign |
Het |
| Lrrd1 |
T |
C |
5: 3,899,773 (GRCm39) |
I26T |
possibly damaging |
Het |
| Mark1 |
C |
T |
1: 184,644,303 (GRCm39) |
G454S |
probably benign |
Het |
| Mrpl20 |
T |
C |
4: 155,893,041 (GRCm39) |
F91L |
probably benign |
Het |
| Nt5c3b |
A |
T |
11: 100,323,735 (GRCm39) |
|
probably benign |
Het |
| Osbpl2 |
T |
C |
2: 179,792,051 (GRCm39) |
Y252H |
possibly damaging |
Het |
| Pard3 |
A |
G |
8: 128,115,159 (GRCm39) |
N626D |
probably damaging |
Het |
| Pbrm1 |
C |
T |
14: 30,840,733 (GRCm39) |
P1612S |
probably damaging |
Het |
| Sall4 |
T |
C |
2: 168,597,700 (GRCm39) |
D380G |
probably damaging |
Het |
| Sema3b |
A |
C |
9: 107,481,240 (GRCm39) |
|
probably null |
Het |
| Spred1 |
C |
T |
2: 117,008,339 (GRCm39) |
P415L |
probably damaging |
Het |
| Tnc |
T |
A |
4: 63,883,844 (GRCm39) |
D1958V |
probably damaging |
Het |
| Tnfsf15 |
A |
G |
4: 63,652,483 (GRCm39) |
|
probably benign |
Het |
| Usp24 |
T |
A |
4: 106,229,876 (GRCm39) |
|
probably benign |
Het |
|
| Other mutations in Prl3d3 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01124:Prl3d3
|
APN |
13 |
27,343,090 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R0627:Prl3d3
|
UTSW |
13 |
27,340,830 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R2063:Prl3d3
|
UTSW |
13 |
27,346,304 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4989:Prl3d3
|
UTSW |
13 |
27,343,072 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R5665:Prl3d3
|
UTSW |
13 |
27,343,064 (GRCm39) |
splice site |
probably null |
|
|
R6254:Prl3d3
|
UTSW |
13 |
27,341,453 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R6682:Prl3d3
|
UTSW |
13 |
27,345,023 (GRCm39) |
missense |
probably benign |
0.44 |
|
R6727:Prl3d3
|
UTSW |
13 |
27,341,147 (GRCm39) |
splice site |
probably null |
|
|
R6793:Prl3d3
|
UTSW |
13 |
27,345,044 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6953:Prl3d3
|
UTSW |
13 |
27,345,029 (GRCm39) |
missense |
probably benign |
0.17 |
|
R6979:Prl3d3
|
UTSW |
13 |
27,341,545 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R7503:Prl3d3
|
UTSW |
13 |
27,345,096 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8872:Prl3d3
|
UTSW |
13 |
27,346,324 (GRCm39) |
missense |
possibly damaging |
0.63 |
|
R9258:Prl3d3
|
UTSW |
13 |
27,344,931 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
| Posted On |
2012-12-06 |
Incidental Mutation