Incidental Mutation 'IGL00661:Prl4a1'
ID 10354
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Prl4a1
Ensembl Gene ENSMUSG00000005891
Gene Name prolactin family 4, subfamily a, member 1
Synonyms Prlpa, PLP-A
Accession Numbers
Essential gene? Probably non essential (E-score: 0.077) question?
Stock # IGL00661
Quality Score
Status
Chromosome 13
Chromosomal Location 28200195-28207531 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 28205359 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Alanine at position 108 (V108A)
Ref Sequence ENSEMBL: ENSMUSP00000021779 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000021779]
AlphaFold O35256
Predicted Effect probably benign
Transcript: ENSMUST00000021779
AA Change: V108A

PolyPhen 2 Score 0.164 (Sensitivity: 0.92; Specificity: 0.87)
SMART Domains Protein: ENSMUSP00000021779
Gene: ENSMUSG00000005891
AA Change: V108A

DomainStartEndE-ValueType
Pfam:Hormone_1 17 227 1.8e-71 PFAM
Coding Region Coverage
Validation Efficiency
MGI Phenotype PHENOTYPE: Female mice homozygous for a knock-out allele are unable to adapt to hypobaric hypoxia during gestation, resulting in pregnancy failure. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 30 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
AAdacl4fm3 A G 4: 144,430,263 (GRCm39) V242A possibly damaging Het
Antxr2 T C 5: 98,152,155 (GRCm39) D152G probably benign Het
Blmh A T 11: 76,856,758 (GRCm39) K118* probably null Het
Bnip3 G A 7: 138,499,801 (GRCm39) P62L probably damaging Het
Catsperb A T 12: 101,554,357 (GRCm39) T684S probably damaging Het
Chd3 C A 11: 69,248,209 (GRCm39) K894N possibly damaging Het
Chkb T A 15: 89,311,794 (GRCm39) R133S probably benign Het
Dennd5a T C 7: 109,507,579 (GRCm39) N803S probably benign Het
Dync2li1 A T 17: 84,956,668 (GRCm39) D276V possibly damaging Het
Erap1 T C 13: 74,822,908 (GRCm39) probably benign Het
Hgsnat C T 8: 26,462,965 (GRCm39) V70M probably benign Het
Leprot T C 4: 101,509,673 (GRCm39) probably null Het
Lhcgr G A 17: 89,057,546 (GRCm39) A315V probably benign Het
Lrrn4 C T 2: 132,712,588 (GRCm39) V412I probably benign Het
Macrod2 G A 2: 140,261,824 (GRCm39) probably null Het
Mmaa G A 8: 80,008,199 (GRCm39) R13C probably damaging Het
Plpp4 T A 7: 128,918,023 (GRCm39) I66N probably damaging Het
Prss1 G T 6: 41,439,553 (GRCm39) K95N possibly damaging Het
Rasa2 C T 9: 96,459,606 (GRCm39) probably benign Het
Relb A G 7: 19,350,336 (GRCm39) V208A possibly damaging Het
Sema3d T C 5: 12,555,806 (GRCm39) S178P probably damaging Het
Slc18a1 A T 8: 69,526,383 (GRCm39) W102R probably benign Het
Slc39a8 A C 3: 135,563,873 (GRCm39) K239N probably benign Het
Stap1 A G 5: 86,229,132 (GRCm39) H100R probably benign Het
Suz12 T A 11: 79,889,918 (GRCm39) V143E probably damaging Het
Tmf1 A G 6: 97,153,455 (GRCm39) V206A probably benign Het
Trim16 T A 11: 62,728,058 (GRCm39) probably benign Het
Ube2b C T 11: 51,891,119 (GRCm39) probably null Het
Vmn1r223 T C 13: 23,434,254 (GRCm39) S283P probably damaging Het
Wrn T A 8: 33,809,173 (GRCm39) probably benign Het
Other mutations in Prl4a1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00087:Prl4a1 APN 13 28,205,443 (GRCm39) missense probably damaging 0.99
IGL02192:Prl4a1 APN 13 28,202,554 (GRCm39) missense possibly damaging 0.69
IGL03006:Prl4a1 APN 13 28,207,359 (GRCm39) missense probably damaging 1.00
IGL03071:Prl4a1 APN 13 28,204,246 (GRCm39) missense probably benign 0.32
R4974:Prl4a1 UTSW 13 28,207,308 (GRCm39) missense possibly damaging 0.89
R5208:Prl4a1 UTSW 13 28,202,467 (GRCm39) missense probably benign 0.33
R5946:Prl4a1 UTSW 13 28,202,499 (GRCm39) missense probably damaging 0.98
R6387:Prl4a1 UTSW 13 28,202,482 (GRCm39) missense possibly damaging 0.93
R7236:Prl4a1 UTSW 13 28,202,556 (GRCm39) missense probably benign
R8213:Prl4a1 UTSW 13 28,207,369 (GRCm39) nonsense probably null
R8445:Prl4a1 UTSW 13 28,205,445 (GRCm39) missense possibly damaging 0.89
R8828:Prl4a1 UTSW 13 28,207,307 (GRCm39) missense probably damaging 0.99
Posted On 2012-12-06