Incidental Mutation 'IGL01673:Vmn1r74'
ID103554
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Vmn1r74
Ensembl Gene ENSMUSG00000047655
Gene Namevomeronasal 1 receptor 74
SynonymsV1rg5
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.062) question?
Stock #IGL01673
Quality Score
Status
Chromosome7
Chromosomal Location11833980-11853276 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to T at 11847390 bp
ZygosityHeterozygous
Amino Acid Change Isoleucine to Phenylalanine at position 206 (I206F)
Ref Sequence ENSEMBL: ENSMUSP00000154746 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000050416] [ENSMUST00000228471]
Predicted Effect possibly damaging
Transcript: ENSMUST00000050416
AA Change: I206F

PolyPhen 2 Score 0.944 (Sensitivity: 0.80; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000055148
Gene: ENSMUSG00000047655
AA Change: I206F

DomainStartEndE-ValueType
Pfam:7tm_1 22 290 1.3e-7 PFAM
Pfam:V1R 34 296 1.2e-31 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000210930
Predicted Effect possibly damaging
Transcript: ENSMUST00000228471
AA Change: I206F

PolyPhen 2 Score 0.944 (Sensitivity: 0.80; Specificity: 0.95)
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 21 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Cpz A T 5: 35,512,547 V262E probably benign Het
Cyp4f14 A G 17: 32,911,151 probably null Het
Ddx46 G T 13: 55,653,048 V339F probably damaging Het
Gpn1 T G 5: 31,494,835 C21W probably damaging Het
Gpr63 A T 4: 25,008,014 Q246L probably benign Het
Hsp90b1 T A 10: 86,693,432 M658L probably damaging Het
Immp2l T C 12: 41,068,321 S4P probably benign Het
Krtap9-5 A T 11: 99,949,551 *359C probably null Het
Lgals7 A G 7: 28,866,196 probably benign Het
Mak G T 13: 41,048,223 probably null Het
Mrps18c A G 5: 100,798,806 R13G possibly damaging Het
Myo7a A G 7: 98,054,708 V1946A probably benign Het
Nfyc T C 4: 120,779,110 probably benign Het
Nkx2-4 C T 2: 147,083,914 V343M possibly damaging Het
Olfr1105 T C 2: 87,033,387 Y278C probably damaging Het
Olfr924 T C 9: 38,849,020 V302A probably benign Het
Rapgef4 G T 2: 72,241,437 S743I probably damaging Het
Tcf7 A G 11: 52,256,996 C210R probably damaging Het
Ubqln3 T A 7: 104,142,398 I162F probably benign Het
Vmn1r216 A G 13: 23,099,471 Q108R probably damaging Het
Wdr64 T C 1: 175,800,356 I872T possibly damaging Het
Other mutations in Vmn1r74
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01608:Vmn1r74 APN 7 11847633 missense probably damaging 0.98
IGL03023:Vmn1r74 APN 7 11847330 missense possibly damaging 0.46
IGL03409:Vmn1r74 APN 7 11847313 missense probably damaging 0.99
R0393:Vmn1r74 UTSW 7 11847315 missense possibly damaging 0.79
R1488:Vmn1r74 UTSW 7 11847583 missense probably benign 0.02
R1707:Vmn1r74 UTSW 7 11847577 missense probably damaging 0.98
R1998:Vmn1r74 UTSW 7 11847375 missense probably damaging 1.00
R1999:Vmn1r74 UTSW 7 11847375 missense probably damaging 1.00
R2139:Vmn1r74 UTSW 7 11847316 missense probably damaging 1.00
R4027:Vmn1r74 UTSW 7 11846971 missense probably damaging 0.98
R4576:Vmn1r74 UTSW 7 11846769 unclassified probably null
R4619:Vmn1r74 UTSW 7 11847471 missense possibly damaging 0.61
R4619:Vmn1r74 UTSW 7 11847476 missense probably damaging 1.00
R5371:Vmn1r74 UTSW 7 11847057 missense probably damaging 1.00
R5606:Vmn1r74 UTSW 7 11846895 missense probably benign 0.01
R6464:Vmn1r74 UTSW 7 11847204 missense possibly damaging 0.87
R6901:Vmn1r74 UTSW 7 11847441 missense probably benign 0.00
R6920:Vmn1r74 UTSW 7 11847648 missense probably benign 0.01
R7223:Vmn1r74 UTSW 7 11846967 nonsense probably null
R7231:Vmn1r74 UTSW 7 11846961 missense probably benign 0.34
R7418:Vmn1r74 UTSW 7 11847154 missense possibly damaging 0.88
R8135:Vmn1r74 UTSW 7 11847603 missense probably benign 0.36
RF049:Vmn1r74 UTSW 7 11847140 frame shift probably null
RF063:Vmn1r74 UTSW 7 11847140 frame shift probably null
Z1176:Vmn1r74 UTSW 7 11847009 missense probably benign
Posted On2014-01-21