Incidental Mutation 'IGL01674:Olfr1097'
ID103574
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr1097
Ensembl Gene ENSMUSG00000075170
Gene Nameolfactory receptor 1097
SynonymsMOR206-2, GA_x6K02T2Q125-48376288-48375341
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.050) question?
Stock #IGL01674
Quality Score
Status
Chromosome2
Chromosomal Location86886773-86892216 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to C at 86890749 bp
ZygosityHeterozygous
Amino Acid Change Tyrosine to Cysteine at position 142 (Y142C)
Ref Sequence ENSEMBL: ENSMUSP00000150400 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000111576] [ENSMUST00000217403]
Predicted Effect probably benign
Transcript: ENSMUST00000111576
AA Change: Y142C

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000107202
Gene: ENSMUSG00000075170
AA Change: Y142C

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 8e-52 PFAM
Pfam:7tm_1 41 312 4.2e-20 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000217403
AA Change: Y142C

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 36 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Arhgef39 A G 4: 43,497,590 L222P probably damaging Het
Art3 T A 5: 92,403,614 Y17* probably null Het
Cadps2 A G 6: 23,355,852 L859P probably damaging Het
Celsr2 A G 3: 108,414,843 Y218H probably damaging Het
Ces5a A G 8: 93,502,219 V461A probably damaging Het
Clic4 C A 4: 135,238,893 V51L probably benign Het
Col6a3 A G 1: 90,802,514 L1083P probably damaging Het
Cul5 T C 9: 53,635,007 E328G probably damaging Het
Erap1 T C 13: 74,664,231 probably benign Het
Fn1 G A 1: 71,606,741 P1527L probably damaging Het
Gm20547 T A 17: 34,881,655 Q63L probably benign Het
Gm5089 T C 14: 122,436,163 T49A unknown Het
Ippk T C 13: 49,449,264 L362S probably damaging Het
Krt23 T C 11: 99,486,767 M138V probably benign Het
Magi3 A G 3: 104,105,721 probably benign Het
Mcc T A 18: 44,491,156 I266F probably benign Het
Mcph1 A G 8: 18,631,519 E224G probably damaging Het
Neurod4 A T 10: 130,271,018 L129H probably damaging Het
Olfr1230 T A 2: 89,296,670 N200I probably damaging Het
Olfr126 T A 17: 37,609,962 D263V probably damaging Het
Olfr1449 T C 19: 12,935,562 S275P probably damaging Het
Piezo2 A T 18: 63,027,559 I2342N probably damaging Het
Pnpt1 A G 11: 29,155,787 Q632R probably benign Het
Ppp2r2c T C 5: 36,940,226 M252T possibly damaging Het
Ppp4r2 A G 6: 100,864,683 N142D possibly damaging Het
Prex2 G T 1: 11,170,741 K1024N probably damaging Het
Rimklb T A 6: 122,459,170 I150F probably damaging Het
Slco4c1 T C 1: 96,842,493 Q282R probably damaging Het
Tmem92 T C 11: 94,778,693 E148G probably damaging Het
Traf7 T C 17: 24,510,375 probably benign Het
Ubr5 G A 15: 37,998,379 T1622M probably damaging Het
Vmn1r5 T A 6: 56,985,926 S195R probably damaging Het
Vmn2r67 C T 7: 85,136,443 V785I probably damaging Het
Ythdc2 G A 18: 44,860,404 D839N probably benign Het
Zfp184 T C 13: 21,950,225 probably benign Het
Zfp654 T C 16: 64,784,641 N525S probably benign Het
Other mutations in Olfr1097
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00336:Olfr1097 APN 2 86890245 missense probably benign
IGL02089:Olfr1097 APN 2 86891116 missense possibly damaging 0.86
IGL02201:Olfr1097 APN 2 86891076 missense probably damaging 0.97
IGL02426:Olfr1097 APN 2 86890620 missense probably damaging 1.00
IGL02469:Olfr1097 APN 2 86891155 missense possibly damaging 0.91
IGL02489:Olfr1097 APN 2 86890995 missense probably damaging 1.00
IGL02817:Olfr1097 APN 2 86890593 missense probably benign
R0042:Olfr1097 UTSW 2 86890491 missense probably damaging 1.00
R0605:Olfr1097 UTSW 2 86890419 missense possibly damaging 0.65
R1867:Olfr1097 UTSW 2 86890612 missense probably damaging 0.98
R2412:Olfr1097 UTSW 2 86890834 missense probably benign 0.01
R4465:Olfr1097 UTSW 2 86891150 missense probably benign
R4520:Olfr1097 UTSW 2 86891019 missense probably benign 0.20
R5185:Olfr1097 UTSW 2 86890602 missense probably benign 0.42
R5329:Olfr1097 UTSW 2 86890620 missense probably damaging 1.00
R5496:Olfr1097 UTSW 2 86890314 missense probably damaging 1.00
R5496:Olfr1097 UTSW 2 86890315 missense probably damaging 1.00
R5847:Olfr1097 UTSW 2 86890332 missense probably damaging 0.99
R6288:Olfr1097 UTSW 2 86890882 missense probably benign 0.01
R6906:Olfr1097 UTSW 2 86890747 missense probably benign
R7161:Olfr1097 UTSW 2 86890649 missense probably benign 0.01
R7256:Olfr1097 UTSW 2 86890612 missense probably damaging 0.98
R7404:Olfr1097 UTSW 2 86890873 missense probably benign 0.05
Posted On2014-01-21