Incidental Mutation 'IGL01674:Zfp654'
ID |
103583 |
Institutional Source |
Australian Phenomics Network
(link to record)
|
Gene Symbol |
Zfp654
|
Ensembl Gene |
ENSMUSG00000047141 |
Gene Name |
zinc finger protein 654 |
Synonyms |
Gm5488, 1600021C16Rik, 1810008K20Rik |
Accession Numbers |
|
Essential gene? |
Possibly essential
(E-score: 0.723)
|
Stock # |
IGL01674
|
Quality Score |
|
Status
|
|
Chromosome |
16 |
Chromosomal Location |
64600710-64672015 bp(-) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
T to C
at 64605004 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Asparagine to Serine
at position 525
(N525S)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000052946
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000052588]
[ENSMUST00000207826]
|
AlphaFold |
Q9DAU9 |
Predicted Effect |
probably benign
Transcript: ENSMUST00000052588
AA Change: N525S
PolyPhen 2
Score 0.017 (Sensitivity: 0.95; Specificity: 0.80)
|
SMART Domains |
Protein: ENSMUSP00000052946 Gene: ENSMUSG00000047141 AA Change: N525S
Domain | Start | End | E-Value | Type |
ZnF_C2H2
|
25 |
47 |
1.69e-3 |
SMART |
low complexity region
|
117 |
132 |
N/A |
INTRINSIC |
low complexity region
|
150 |
167 |
N/A |
INTRINSIC |
ZnF_C2H2
|
197 |
222 |
1.25e-1 |
SMART |
ZnF_C2H2
|
238 |
260 |
4.65e-1 |
SMART |
ZnF_C2H2
|
266 |
290 |
4.98e-1 |
SMART |
ZnF_C2H2
|
295 |
319 |
7.49e0 |
SMART |
ZnF_C2H2
|
534 |
554 |
1.49e2 |
SMART |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000207826
AA Change: N1066S
PolyPhen 2
Score 0.008 (Sensitivity: 0.96; Specificity: 0.76)
|
Coding Region Coverage |
|
Validation Efficiency |
|
Allele List at MGI |
|
Other mutations in this stock |
Total: 36 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
Arhgef39 |
A |
G |
4: 43,497,590 (GRCm39) |
L222P |
probably damaging |
Het |
Art3 |
T |
A |
5: 92,551,473 (GRCm39) |
Y17* |
probably null |
Het |
Cadps2 |
A |
G |
6: 23,355,851 (GRCm39) |
L859P |
probably damaging |
Het |
Celsr2 |
A |
G |
3: 108,322,159 (GRCm39) |
Y218H |
probably damaging |
Het |
Ces5a |
A |
G |
8: 94,228,847 (GRCm39) |
V461A |
probably damaging |
Het |
Clic4 |
C |
A |
4: 134,966,204 (GRCm39) |
V51L |
probably benign |
Het |
Col6a3 |
A |
G |
1: 90,730,236 (GRCm39) |
L1083P |
probably damaging |
Het |
Cul5 |
T |
C |
9: 53,546,307 (GRCm39) |
E328G |
probably damaging |
Het |
Erap1 |
T |
C |
13: 74,812,350 (GRCm39) |
|
probably benign |
Het |
Fn1 |
G |
A |
1: 71,645,900 (GRCm39) |
P1527L |
probably damaging |
Het |
Gm20547 |
T |
A |
17: 35,100,631 (GRCm39) |
Q63L |
probably benign |
Het |
Gm5089 |
T |
C |
14: 122,673,575 (GRCm39) |
T49A |
unknown |
Het |
Ippk |
T |
C |
13: 49,602,740 (GRCm39) |
L362S |
probably damaging |
Het |
Krt23 |
T |
C |
11: 99,377,593 (GRCm39) |
M138V |
probably benign |
Het |
Magi3 |
A |
G |
3: 104,013,037 (GRCm39) |
|
probably benign |
Het |
Mcc |
T |
A |
18: 44,624,223 (GRCm39) |
I266F |
probably benign |
Het |
Mcph1 |
A |
G |
8: 18,681,535 (GRCm39) |
E224G |
probably damaging |
Het |
Neurod4 |
A |
T |
10: 130,106,887 (GRCm39) |
L129H |
probably damaging |
Het |
Or14j5 |
T |
A |
17: 37,920,853 (GRCm39) |
D263V |
probably damaging |
Het |
Or4c123 |
T |
A |
2: 89,127,014 (GRCm39) |
N200I |
probably damaging |
Het |
Or5b24 |
T |
C |
19: 12,912,926 (GRCm39) |
S275P |
probably damaging |
Het |
Or8h7 |
T |
C |
2: 86,721,093 (GRCm39) |
Y142C |
probably benign |
Het |
Piezo2 |
A |
T |
18: 63,160,630 (GRCm39) |
I2342N |
probably damaging |
Het |
Pnpt1 |
A |
G |
11: 29,105,787 (GRCm39) |
Q632R |
probably benign |
Het |
Ppp2r2c |
T |
C |
5: 37,097,570 (GRCm39) |
M252T |
possibly damaging |
Het |
Ppp4r2 |
A |
G |
6: 100,841,644 (GRCm39) |
N142D |
possibly damaging |
Het |
Prex2 |
G |
T |
1: 11,240,965 (GRCm39) |
K1024N |
probably damaging |
Het |
Rimklb |
T |
A |
6: 122,436,129 (GRCm39) |
I150F |
probably damaging |
Het |
Slco4c1 |
T |
C |
1: 96,770,218 (GRCm39) |
Q282R |
probably damaging |
Het |
Tmem92 |
T |
C |
11: 94,669,519 (GRCm39) |
E148G |
probably damaging |
Het |
Traf7 |
T |
C |
17: 24,729,349 (GRCm39) |
|
probably benign |
Het |
Ubr5 |
G |
A |
15: 37,998,623 (GRCm39) |
T1622M |
probably damaging |
Het |
Vmn1r5 |
T |
A |
6: 56,962,911 (GRCm39) |
S195R |
probably damaging |
Het |
Vmn2r67 |
C |
T |
7: 84,785,651 (GRCm39) |
V785I |
probably damaging |
Het |
Ythdc2 |
G |
A |
18: 44,993,471 (GRCm39) |
D839N |
probably benign |
Het |
Zfp184 |
T |
C |
13: 22,134,395 (GRCm39) |
|
probably benign |
Het |
|
Other mutations in Zfp654 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL02043:Zfp654
|
APN |
16 |
64,605,391 (GRCm39) |
missense |
probably benign |
0.00 |
IGL02205:Zfp654
|
APN |
16 |
64,606,329 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL02337:Zfp654
|
APN |
16 |
64,605,512 (GRCm39) |
missense |
probably benign |
0.00 |
IGL02398:Zfp654
|
APN |
16 |
64,606,381 (GRCm39) |
missense |
probably benign |
0.00 |
R0025:Zfp654
|
UTSW |
16 |
64,605,181 (GRCm39) |
missense |
probably benign |
0.31 |
R0025:Zfp654
|
UTSW |
16 |
64,605,181 (GRCm39) |
missense |
probably benign |
0.31 |
R0193:Zfp654
|
UTSW |
16 |
64,606,051 (GRCm39) |
missense |
possibly damaging |
0.76 |
R1276:Zfp654
|
UTSW |
16 |
64,605,699 (GRCm39) |
missense |
probably damaging |
1.00 |
R1851:Zfp654
|
UTSW |
16 |
64,605,491 (GRCm39) |
missense |
probably benign |
0.34 |
R4065:Zfp654
|
UTSW |
16 |
64,606,288 (GRCm39) |
missense |
possibly damaging |
0.87 |
R4872:Zfp654
|
UTSW |
16 |
64,606,145 (GRCm39) |
missense |
probably benign |
0.28 |
R5693:Zfp654
|
UTSW |
16 |
64,606,289 (GRCm39) |
missense |
probably benign |
0.00 |
R6362:Zfp654
|
UTSW |
16 |
64,606,457 (GRCm39) |
nonsense |
probably null |
|
R6483:Zfp654
|
UTSW |
16 |
64,612,310 (GRCm39) |
missense |
possibly damaging |
0.93 |
R6666:Zfp654
|
UTSW |
16 |
64,606,596 (GRCm39) |
missense |
probably benign |
0.25 |
R6852:Zfp654
|
UTSW |
16 |
64,606,961 (GRCm39) |
missense |
probably damaging |
1.00 |
R6917:Zfp654
|
UTSW |
16 |
64,606,834 (GRCm39) |
missense |
probably damaging |
0.98 |
R7289:Zfp654
|
UTSW |
16 |
64,605,523 (GRCm39) |
missense |
probably benign |
|
R7506:Zfp654
|
UTSW |
16 |
64,612,211 (GRCm39) |
missense |
probably damaging |
0.98 |
R7598:Zfp654
|
UTSW |
16 |
64,606,297 (GRCm39) |
missense |
possibly damaging |
0.49 |
R7721:Zfp654
|
UTSW |
16 |
64,606,570 (GRCm39) |
missense |
probably damaging |
1.00 |
R7791:Zfp654
|
UTSW |
16 |
64,603,634 (GRCm39) |
makesense |
probably null |
|
R7884:Zfp654
|
UTSW |
16 |
64,672,011 (GRCm39) |
missense |
probably damaging |
0.99 |
R7966:Zfp654
|
UTSW |
16 |
64,605,239 (GRCm39) |
missense |
probably damaging |
1.00 |
R8361:Zfp654
|
UTSW |
16 |
64,612,220 (GRCm39) |
missense |
probably damaging |
1.00 |
R8487:Zfp654
|
UTSW |
16 |
64,606,011 (GRCm39) |
nonsense |
probably null |
|
R8705:Zfp654
|
UTSW |
16 |
64,605,433 (GRCm39) |
missense |
possibly damaging |
0.46 |
R9074:Zfp654
|
UTSW |
16 |
64,611,496 (GRCm39) |
missense |
probably damaging |
0.96 |
Z1176:Zfp654
|
UTSW |
16 |
64,606,571 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Posted On |
2014-01-21 |