Incidental Mutation 'IGL01676:Trim67'
ID103646
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Trim67
Ensembl Gene ENSMUSG00000036913
Gene Nametripartite motif-containing 67
SynonymsD130049O21Rik
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.228) question?
Stock #IGL01676
Quality Score
Status
Chromosome8
Chromosomal Location124793092-124834713 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to T at 124815160 bp
ZygosityHeterozygous
Amino Acid Change Isoleucine to Phenylalanine at position 366 (I366F)
Ref Sequence ENSEMBL: ENSMUSP00000148625 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000041106] [ENSMUST00000167588] [ENSMUST00000211867]
Predicted Effect possibly damaging
Transcript: ENSMUST00000041106
AA Change: I366F

PolyPhen 2 Score 0.507 (Sensitivity: 0.88; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000040601
Gene: ENSMUSG00000036913
AA Change: I366F

DomainStartEndE-ValueType
RING 7 157 1.41e-4 SMART
BBOX 198 248 4.65e-5 SMART
BBOX 285 327 3.04e-9 SMART
BBC 334 460 1.18e-28 SMART
FN3 498 579 1.75e-6 SMART
Pfam:SPRY 635 755 1.3e-13 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000167588
AA Change: I366F

PolyPhen 2 Score 0.507 (Sensitivity: 0.88; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000130343
Gene: ENSMUSG00000036913
AA Change: I366F

DomainStartEndE-ValueType
RING 7 157 1.41e-4 SMART
BBOX 198 248 4.65e-5 SMART
BBOX 285 327 3.04e-9 SMART
BBC 334 460 1.18e-28 SMART
FN3 498 579 1.75e-6 SMART
Pfam:SPRY 633 756 3.6e-17 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000211867
AA Change: I366F

PolyPhen 2 Score 0.507 (Sensitivity: 0.88; Specificity: 0.90)
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 30 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acsm4 A T 7: 119,708,643 R334S probably benign Het
Adamts3 A T 5: 89,677,754 F1075L probably benign Het
Adamts3 A G 5: 89,881,543 V30A possibly damaging Het
Bpifb5 A G 2: 154,229,049 N223D possibly damaging Het
Cacna1e T C 1: 154,398,476 R2228G probably damaging Het
Cacna1e T C 1: 154,412,450 E1894G probably damaging Het
Calr4 A G 4: 109,244,250 K110E probably damaging Het
Catsperz G T 19: 6,925,053 Y24* probably null Het
Clec9a T G 6: 129,421,155 S219A probably benign Het
Csrnp3 T A 2: 65,948,992 I16N probably damaging Het
Ddx19a A G 8: 110,980,989 probably null Het
Diaph1 G A 18: 37,856,188 Q905* probably null Het
Dnah10 T C 5: 124,803,328 M2743T possibly damaging Het
Ears2 A T 7: 122,044,558 D392E probably benign Het
Fsip1 T C 2: 118,240,384 probably benign Het
Gm9268 A G 7: 43,024,709 N397S probably damaging Het
Ighv1-74 T C 12: 115,802,703 Y98C possibly damaging Het
Igsf10 T C 3: 59,326,011 K1767R probably benign Het
Igsf10 C T 3: 59,329,335 A1142T probably benign Het
Lpar6 A G 14: 73,239,570 N324D probably benign Het
Lrit1 T A 14: 37,057,437 L109Q probably damaging Het
Nlrp4f A T 13: 65,195,119 D237E possibly damaging Het
Oas1h G T 5: 120,871,834 G324V probably damaging Het
Pak1 T G 7: 97,883,531 D179E probably benign Het
Prop1 T A 11: 50,952,129 Q77L probably damaging Het
Scn10a A T 9: 119,672,165 Y184* probably null Het
Sdk1 T C 5: 142,127,836 F1546S probably damaging Het
Vmn2r94 T G 17: 18,257,010 M380L probably benign Het
Zfand3 T G 17: 30,135,363 S51R possibly damaging Het
Zfp36l3 T C X: 53,775,657 S197G probably benign Het
Other mutations in Trim67
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00817:Trim67 APN 8 124815060 splice site probably benign
IGL01779:Trim67 APN 8 124828121 missense probably damaging 1.00
IGL02057:Trim67 APN 8 124823130 missense probably benign 0.00
IGL02201:Trim67 APN 8 124794058 missense probably benign 0.26
IGL02304:Trim67 APN 8 124825952 missense probably damaging 1.00
R0068:Trim67 UTSW 8 124794568 missense probably damaging 0.97
R0241:Trim67 UTSW 8 124823190 missense probably damaging 0.99
R0319:Trim67 UTSW 8 124823227 missense probably damaging 0.98
R0471:Trim67 UTSW 8 124794658 missense probably benign 0.01
R1171:Trim67 UTSW 8 124829081 missense probably damaging 0.97
R1175:Trim67 UTSW 8 124817035 missense probably damaging 0.99
R1444:Trim67 UTSW 8 124823193 missense probably benign 0.01
R1596:Trim67 UTSW 8 124826139 missense probably damaging 0.97
R1706:Trim67 UTSW 8 124794421 missense probably damaging 1.00
R4951:Trim67 UTSW 8 124794667 missense probably benign
R5200:Trim67 UTSW 8 124824850 missense probably damaging 0.99
R5787:Trim67 UTSW 8 124794312 nonsense probably null
R6023:Trim67 UTSW 8 124815104 missense probably damaging 0.99
R6290:Trim67 UTSW 8 124823179 missense probably benign 0.00
R6536:Trim67 UTSW 8 124794342 missense possibly damaging 0.51
R7315:Trim67 UTSW 8 124794330 missense probably benign 0.18
R7660:Trim67 UTSW 8 124820285 missense probably damaging 1.00
R8432:Trim67 UTSW 8 124794062 small deletion probably benign
R8446:Trim67 UTSW 8 124793991 missense probably damaging 0.99
R8713:Trim67 UTSW 8 124820335 missense probably null 0.06
Z1088:Trim67 UTSW 8 124817041 missense probably damaging 0.99
Posted On2014-01-21