Incidental Mutation 'IGL01677:Olfr669'
ID103661
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr669
Ensembl Gene ENSMUSG00000073916
Gene Nameolfactory receptor 669
SynonymsMOR34-6, GA_x6K02T2PBJ9-7567376-7568329
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.142) question?
Stock #IGL01677
Quality Score
Status
Chromosome7
Chromosomal Location104934240-104940477 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to C at 104938645 bp
ZygosityHeterozygous
Amino Acid Change Serine to Proline at position 40 (S40P)
Ref Sequence ENSEMBL: ENSMUSP00000150928 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000098164] [ENSMUST00000210138] [ENSMUST00000214260]
Predicted Effect probably benign
Transcript: ENSMUST00000098164
AA Change: S40P

PolyPhen 2 Score 0.008 (Sensitivity: 0.96; Specificity: 0.76)
SMART Domains Protein: ENSMUSP00000095767
Gene: ENSMUSG00000073916
AA Change: S40P

DomainStartEndE-ValueType
Pfam:7tm_4 33 313 8.7e-103 PFAM
Pfam:7TM_GPCR_Srsx 37 209 1.9e-10 PFAM
Pfam:7tm_1 43 295 2.7e-18 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000210138
AA Change: S40P

PolyPhen 2 Score 0.008 (Sensitivity: 0.96; Specificity: 0.76)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000211559
Predicted Effect probably benign
Transcript: ENSMUST00000214260
AA Change: S40P

PolyPhen 2 Score 0.008 (Sensitivity: 0.96; Specificity: 0.76)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 33 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Arap3 T A 18: 37,996,647 M154L probably benign Het
Asph T C 4: 9,607,853 D131G probably damaging Het
Cdc45 G A 16: 18,787,000 T429I probably benign Het
Cnga3 C T 1: 37,244,918 R101* probably null Het
Cp T C 3: 19,966,434 I197T probably damaging Het
Cyp4b1 T C 4: 115,636,282 D77G probably damaging Het
Dnah5 G T 15: 28,367,782 W2771L probably damaging Het
Fas G A 19: 34,318,818 V177I probably benign Het
Gde1 A G 7: 118,694,487 probably benign Het
Hyou1 T C 9: 44,382,012 S223P probably benign Het
Klre1 G T 6: 129,582,043 G75C probably damaging Het
Lama1 T C 17: 67,779,148 C1461R probably benign Het
Map3k7 T C 4: 32,017,158 probably benign Het
Mrpl18 A T 17: 12,911,688 I178N probably damaging Het
Nckap1 T C 2: 80,530,297 T503A probably benign Het
Olfr134 T C 17: 38,175,875 S264P probably damaging Het
Olfr654 T C 7: 104,588,145 S114P probably damaging Het
Olfr846 T C 9: 19,361,145 D70G probably damaging Het
Orc1 C T 4: 108,604,585 T593I probably damaging Het
Phtf1 T A 3: 103,998,783 S594T probably damaging Het
Ppp1r13b A T 12: 111,843,665 D78E probably benign Het
Proz T C 8: 13,065,238 probably benign Het
Rtcb C A 10: 85,943,929 Q292H probably damaging Het
Sept11 A T 5: 93,148,533 T95S probably damaging Het
Slc12a1 A G 2: 125,178,149 probably benign Het
Slc45a3 T A 1: 131,978,970 I394N probably damaging Het
Slc8a1 T C 17: 81,648,607 H334R probably damaging Het
Sort1 T C 3: 108,344,885 I466T probably benign Het
Susd2 A T 10: 75,639,431 V515E possibly damaging Het
Ttll3 A G 6: 113,412,984 R778G probably benign Het
Ubfd1 T A 7: 122,071,699 probably benign Het
Utrn G A 10: 12,744,157 T248M probably damaging Het
Vmn2r11 T G 5: 109,053,957 D227A possibly damaging Het
Other mutations in Olfr669
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01527:Olfr669 APN 7 104938991 missense possibly damaging 0.88
IGL01900:Olfr669 APN 7 104939162 missense probably damaging 1.00
IGL02270:Olfr669 APN 7 104939369 missense possibly damaging 0.95
R0482:Olfr669 UTSW 7 104938814 missense possibly damaging 0.56
R0970:Olfr669 UTSW 7 104939077 missense probably benign 0.05
R4260:Olfr669 UTSW 7 104938596 missense probably damaging 0.99
R4845:Olfr669 UTSW 7 104939363 missense possibly damaging 0.95
R4947:Olfr669 UTSW 7 104938742 missense possibly damaging 0.95
R5438:Olfr669 UTSW 7 104939137 missense probably benign 0.03
R5735:Olfr669 UTSW 7 104938759 missense probably benign 0.01
R5943:Olfr669 UTSW 7 104938643 missense possibly damaging 0.78
R6435:Olfr669 UTSW 7 104938834 missense probably damaging 0.99
R6942:Olfr669 UTSW 7 104938897 missense possibly damaging 0.56
R7061:Olfr669 UTSW 7 104938676 missense probably damaging 1.00
R7122:Olfr669 UTSW 7 104939198 missense probably damaging 0.99
R7378:Olfr669 UTSW 7 104939431 missense probably benign 0.31
Posted On2014-01-21