Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01677:Gde1'

103686

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Gde1

Ensembl Gene

ENSMUSG00000033917

Gene Name

glycerophosphodiester phosphodiesterase 1

Synonyms

1200003M13Rik, MIR16

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.153) question?

Stock #

IGL01677

Quality Score

Status

Chromosome

Chromosomal Location

118287781-118304961 bp(-) (GRCm39)

Type of Mutation

splice site

DNA Base Change (assembly)

A to G at 118293710 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000147251 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000038791] [ENSMUST00000132509] [ENSMUST00000207323] [ENSMUST00000208040]

AlphaFold

Q9JL56

Predicted Effect

probably benign
Transcript: ENSMUST00000038791

SMART Domains

Protein: ENSMUSP00000046371
Gene: ENSMUSG00000033917

Domain	Start	End	E-Value	Type
low complexity region	17	24	N/A	INTRINSIC
Pfam:GDPD	70	325	1.1e-35	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000132509

SMART Domains

Protein: ENSMUSP00000122015
Gene: ENSMUSG00000033917

Domain	Start	End	E-Value	Type
Pfam:GDPD	1	135	1.7e-12	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000207323

Predicted Effect

probably benign
Transcript: ENSMUST00000208040

Coding Region Coverage

Validation Efficiency

MGI Phenotype

PHENOTYPE: Mice homozygous for a knock-out allele lack glycero-phospho-N-acyl ethanolamine (GP-NAE) phosphodiesterase activity in the brain. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 33 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Arap3	T	A	18: 38,129,700 (GRCm39)	M154L	probably benign	Het
Asph	T	C	4: 9,607,853 (GRCm39)	D131G	probably damaging	Het
Cdc45	G	A	16: 18,605,750 (GRCm39)	T429I	probably benign	Het
Cnga3	C	T	1: 37,283,999 (GRCm39)	R101*	probably null	Het
Cp	T	C	3: 20,020,598 (GRCm39)	I197T	probably damaging	Het
Cyp4b1	T	C	4: 115,493,479 (GRCm39)	D77G	probably damaging	Het
Dnah5	G	T	15: 28,367,928 (GRCm39)	W2771L	probably damaging	Het
Fas	G	A	19: 34,296,218 (GRCm39)	V177I	probably benign	Het
Hyou1	T	C	9: 44,293,309 (GRCm39)	S223P	probably benign	Het
Klre1	G	T	6: 129,559,006 (GRCm39)	G75C	probably damaging	Het
Lama1	T	C	17: 68,086,143 (GRCm39)	C1461R	probably benign	Het
Map3k7	T	C	4: 32,017,158 (GRCm39)		probably benign	Het
Mrpl18	A	T	17: 13,130,575 (GRCm39)	I178N	probably damaging	Het
Nckap1	T	C	2: 80,360,641 (GRCm39)	T503A	probably benign	Het
Or2n1	T	C	17: 38,486,766 (GRCm39)	S264P	probably damaging	Het
Or52n5	T	C	7: 104,587,852 (GRCm39)	S40P	probably benign	Het
Or52u1	T	C	7: 104,237,352 (GRCm39)	S114P	probably damaging	Het
Or7g28	T	C	9: 19,272,441 (GRCm39)	D70G	probably damaging	Het
Orc1	C	T	4: 108,461,782 (GRCm39)	T593I	probably damaging	Het
Phtf1	T	A	3: 103,906,099 (GRCm39)	S594T	probably damaging	Het
Ppp1r13b	A	T	12: 111,810,099 (GRCm39)	D78E	probably benign	Het
Proz	T	C	8: 13,115,238 (GRCm39)		probably benign	Het
Rtcb	C	A	10: 85,779,793 (GRCm39)	Q292H	probably damaging	Het
Septin11	A	T	5: 93,296,392 (GRCm39)	T95S	probably damaging	Het
Slc12a1	A	G	2: 125,020,069 (GRCm39)		probably benign	Het
Slc45a3	T	A	1: 131,906,708 (GRCm39)	I394N	probably damaging	Het
Slc8a1	T	C	17: 81,956,036 (GRCm39)	H334R	probably damaging	Het
Sort1	T	C	3: 108,252,201 (GRCm39)	I466T	probably benign	Het
Susd2	A	T	10: 75,475,265 (GRCm39)	V515E	possibly damaging	Het
Ttll3	A	G	6: 113,389,945 (GRCm39)	R778G	probably benign	Het
Ubfd1	T	A	7: 121,670,922 (GRCm39)		probably benign	Het
Utrn	G	A	10: 12,619,901 (GRCm39)	T248M	probably damaging	Het
Vmn2r11	T	G	5: 109,201,823 (GRCm39)	D227A	possibly damaging	Het

Other mutations in Gde1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00736:Gde1	APN	7	118,297,925 (GRCm39)	missense	probably damaging	1.00
IGL01288:Gde1	APN	7	118,290,863 (GRCm39)	missense	possibly damaging	0.63
IGL01370:Gde1	APN	7	118,288,383 (GRCm39)	unclassified	probably benign
IGL02701:Gde1	APN	7	118,297,860 (GRCm39)	missense	probably damaging	1.00
R0130:Gde1	UTSW	7	118,294,283 (GRCm39)	missense	probably benign	0.24
R1191:Gde1	UTSW	7	118,304,664 (GRCm39)	missense	probably damaging	1.00
R1478:Gde1	UTSW	7	118,291,007 (GRCm39)	missense	probably benign	0.00
R1836:Gde1	UTSW	7	118,294,357 (GRCm39)	missense	possibly damaging	0.66
R2357:Gde1	UTSW	7	118,290,814 (GRCm39)	missense	probably benign	0.11
R4373:Gde1	UTSW	7	118,297,781 (GRCm39)	missense	possibly damaging	0.91
R4658:Gde1	UTSW	7	118,293,751 (GRCm39)	missense	probably benign
R5364:Gde1	UTSW	7	118,297,874 (GRCm39)	missense	probably benign	0.00
R5367:Gde1	UTSW	7	118,304,629 (GRCm39)	missense	probably damaging	1.00
R6255:Gde1	UTSW	7	118,291,004 (GRCm39)	missense	probably null	0.00
R7604:Gde1	UTSW	7	118,304,759 (GRCm39)	missense	possibly damaging	0.95
R7981:Gde1	UTSW	7	118,288,264 (GRCm39)	missense	probably damaging	1.00
R8935:Gde1	UTSW	7	118,297,914 (GRCm39)	missense	possibly damaging	0.70
R9100:Gde1	UTSW	7	118,294,305 (GRCm39)	missense	probably benign	0.00

Posted On

2014-01-21