Incidental Mutation 'IGL01677:Map3k7'
ID 103687
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Map3k7
Ensembl Gene ENSMUSG00000028284
Gene Name mitogen-activated protein kinase kinase kinase 7
Synonyms Tak1, transforming growth factor-beta-activated kinase 1, TAK1, transforming growth factor beta-activated kinase 1, TGF-beta activated kinase 1
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # IGL01677
Quality Score
Status
Chromosome 4
Chromosomal Location 31964097-32023467 bp(+) (GRCm39)
Type of Mutation intron
DNA Base Change (assembly) T to C at 32017158 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000103819 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000037607] [ENSMUST00000080933] [ENSMUST00000108183] [ENSMUST00000108184]
AlphaFold Q62073
Predicted Effect probably benign
Transcript: ENSMUST00000037607
SMART Domains Protein: ENSMUSP00000040307
Gene: ENSMUSG00000028284

DomainStartEndE-ValueType
low complexity region 2 16 N/A INTRINSIC
Pfam:Pkinase_Tyr 36 284 1.2e-61 PFAM
Pfam:Pkinase 36 285 2.8e-56 PFAM
low complexity region 361 375 N/A INTRINSIC
low complexity region 453 463 N/A INTRINSIC
low complexity region 484 495 N/A INTRINSIC
coiled coil region 528 593 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000080933
SMART Domains Protein: ENSMUSP00000079734
Gene: ENSMUSG00000028284

DomainStartEndE-ValueType
low complexity region 2 16 N/A INTRINSIC
Pfam:Pkinase_Tyr 36 284 1.7e-61 PFAM
Pfam:Pkinase 36 285 8.4e-58 PFAM
low complexity region 361 375 N/A INTRINSIC
low complexity region 426 436 N/A INTRINSIC
low complexity region 457 468 N/A INTRINSIC
coiled coil region 501 566 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000108183
SMART Domains Protein: ENSMUSP00000103818
Gene: ENSMUSG00000028284

DomainStartEndE-ValueType
low complexity region 2 16 N/A INTRINSIC
S_TKc 36 284 1.6e-63 SMART
low complexity region 361 375 N/A INTRINSIC
low complexity region 426 436 N/A INTRINSIC
low complexity region 457 468 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000108184
SMART Domains Protein: ENSMUSP00000103819
Gene: ENSMUSG00000028284

DomainStartEndE-ValueType
low complexity region 2 16 N/A INTRINSIC
Pfam:Pkinase_Tyr 36 284 5.6e-62 PFAM
Pfam:Pkinase 36 285 2.8e-58 PFAM
low complexity region 361 375 N/A INTRINSIC
low complexity region 453 463 N/A INTRINSIC
low complexity region 484 495 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000131310
Predicted Effect noncoding transcript
Transcript: ENSMUST00000147462
Coding Region Coverage
Validation Efficiency
MGI Phenotype PHENOTYPE: Homozygous null mice display embryonic lethality during organogenesis and may have impaired vascular remodeling, edema, or an open, wavy neural tube. Mice with conditional deletion in immune cells show impaired cell development and activation. [provided by MGI curators]
Allele List at MGI

All alleles(62) : Targeted(7) Gene trapped(55)

Other mutations in this stock
Total: 33 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Arap3 T A 18: 38,129,700 (GRCm39) M154L probably benign Het
Asph T C 4: 9,607,853 (GRCm39) D131G probably damaging Het
Cdc45 G A 16: 18,605,750 (GRCm39) T429I probably benign Het
Cnga3 C T 1: 37,283,999 (GRCm39) R101* probably null Het
Cp T C 3: 20,020,598 (GRCm39) I197T probably damaging Het
Cyp4b1 T C 4: 115,493,479 (GRCm39) D77G probably damaging Het
Dnah5 G T 15: 28,367,928 (GRCm39) W2771L probably damaging Het
Fas G A 19: 34,296,218 (GRCm39) V177I probably benign Het
Gde1 A G 7: 118,293,710 (GRCm39) probably benign Het
Hyou1 T C 9: 44,293,309 (GRCm39) S223P probably benign Het
Klre1 G T 6: 129,559,006 (GRCm39) G75C probably damaging Het
Lama1 T C 17: 68,086,143 (GRCm39) C1461R probably benign Het
Mrpl18 A T 17: 13,130,575 (GRCm39) I178N probably damaging Het
Nckap1 T C 2: 80,360,641 (GRCm39) T503A probably benign Het
Or2n1 T C 17: 38,486,766 (GRCm39) S264P probably damaging Het
Or52n5 T C 7: 104,587,852 (GRCm39) S40P probably benign Het
Or52u1 T C 7: 104,237,352 (GRCm39) S114P probably damaging Het
Or7g28 T C 9: 19,272,441 (GRCm39) D70G probably damaging Het
Orc1 C T 4: 108,461,782 (GRCm39) T593I probably damaging Het
Phtf1 T A 3: 103,906,099 (GRCm39) S594T probably damaging Het
Ppp1r13b A T 12: 111,810,099 (GRCm39) D78E probably benign Het
Proz T C 8: 13,115,238 (GRCm39) probably benign Het
Rtcb C A 10: 85,779,793 (GRCm39) Q292H probably damaging Het
Septin11 A T 5: 93,296,392 (GRCm39) T95S probably damaging Het
Slc12a1 A G 2: 125,020,069 (GRCm39) probably benign Het
Slc45a3 T A 1: 131,906,708 (GRCm39) I394N probably damaging Het
Slc8a1 T C 17: 81,956,036 (GRCm39) H334R probably damaging Het
Sort1 T C 3: 108,252,201 (GRCm39) I466T probably benign Het
Susd2 A T 10: 75,475,265 (GRCm39) V515E possibly damaging Het
Ttll3 A G 6: 113,389,945 (GRCm39) R778G probably benign Het
Ubfd1 T A 7: 121,670,922 (GRCm39) probably benign Het
Utrn G A 10: 12,619,901 (GRCm39) T248M probably damaging Het
Vmn2r11 T G 5: 109,201,823 (GRCm39) D227A possibly damaging Het
Other mutations in Map3k7
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00942:Map3k7 APN 4 32,019,539 (GRCm39) missense probably damaging 1.00
IGL02608:Map3k7 APN 4 31,981,452 (GRCm39) splice site probably benign
IGL02796:Map3k7 UTSW 4 31,979,692 (GRCm39) intron probably benign
R0377:Map3k7 UTSW 4 31,985,731 (GRCm39) missense probably damaging 1.00
R0498:Map3k7 UTSW 4 31,974,814 (GRCm39) splice site probably benign
R1547:Map3k7 UTSW 4 31,991,796 (GRCm39) missense probably benign 0.31
R2360:Map3k7 UTSW 4 31,964,302 (GRCm39) missense unknown
R4709:Map3k7 UTSW 4 31,985,700 (GRCm39) nonsense probably null
R4815:Map3k7 UTSW 4 31,988,592 (GRCm39) missense probably damaging 0.98
R5497:Map3k7 UTSW 4 31,991,719 (GRCm39) missense possibly damaging 0.56
R5813:Map3k7 UTSW 4 31,964,318 (GRCm39) missense probably damaging 1.00
R6349:Map3k7 UTSW 4 31,988,661 (GRCm39) missense possibly damaging 0.87
R7314:Map3k7 UTSW 4 31,985,769 (GRCm39) nonsense probably null
R9251:Map3k7 UTSW 4 32,002,080 (GRCm39) splice site probably benign
R9765:Map3k7 UTSW 4 32,019,519 (GRCm39) missense probably damaging 1.00
X0066:Map3k7 UTSW 4 31,974,848 (GRCm39) missense probably damaging 1.00
Z1176:Map3k7 UTSW 4 32,015,963 (GRCm39) missense probably damaging 1.00
Posted On 2014-01-21