Incidental Mutation 'IGL01678:Gpr37l1'
ID103702
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Gpr37l1
Ensembl Gene ENSMUSG00000026424
Gene NameG protein-coupled receptor 37-like 1
SynonymsCAG-18, D0Kist8
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.066) question?
Stock #IGL01678
Quality Score
Status
Chromosome1
Chromosomal Location135160234-135167681 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to G at 135167053 bp
ZygosityHeterozygous
Amino Acid Change Valine to Alanine at position 151 (V151A)
Ref Sequence ENSEMBL: ENSMUSP00000027682 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000027682]
Predicted Effect probably damaging
Transcript: ENSMUST00000027682
AA Change: V151A

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000027682
Gene: ENSMUSG00000026424
AA Change: V151A

DomainStartEndE-ValueType
signal peptide 1 24 N/A INTRINSIC
Pfam:7tm_1 147 416 4.4e-25 PFAM
low complexity region 430 439 N/A INTRINSIC
low complexity region 442 453 N/A INTRINSIC
Coding Region Coverage
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice homozygous for a knock-out allele may exhibit no abnormal phenotype, precocious cerebellum development and improved motor functions or abnormal blood pressure in female mice. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 34 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcc1 T A 16: 14,405,019 M186K probably null Het
Adamts3 T C 5: 89,707,856 N385S probably damaging Het
Adamts6 T C 13: 104,313,688 V299A probably damaging Het
Angel1 T C 12: 86,717,026 E500G probably benign Het
Car9 T C 4: 43,512,941 probably benign Het
Colec11 A G 12: 28,594,868 F209S probably damaging Het
Dock10 A G 1: 80,543,352 Y1179H probably damaging Het
Ece1 T A 4: 137,962,733 W697R probably damaging Het
Eml2 T A 7: 19,186,122 M117K probably benign Het
Flii G T 11: 60,716,846 probably benign Het
Frmpd1 T A 4: 45,243,717 D63E probably damaging Het
Ftmt A T 18: 52,332,134 H174L probably damaging Het
Gm438 A T 4: 144,777,873 M236K probably benign Het
Gm960 T A 19: 4,672,165 I76L possibly damaging Het
Inppl1 T C 7: 101,832,596 T180A probably benign Het
Klhdc4 T C 8: 121,796,938 D513G possibly damaging Het
Klrb1a A G 6: 128,618,448 probably benign Het
Nit1 A G 1: 171,342,694 V270A probably damaging Het
Olfr774 A C 10: 129,238,668 D173A possibly damaging Het
Phox2b T A 5: 67,098,919 Y8F probably damaging Het
Psg20 T A 7: 18,680,870 S364C probably damaging Het
Rab38 T A 7: 88,430,532 V44E probably damaging Het
Rapgef4 T C 2: 72,242,225 probably benign Het
Ror1 C T 4: 100,425,968 P410L possibly damaging Het
Rptn A G 3: 93,396,811 N484D probably benign Het
Sirpb1a G T 3: 15,411,310 S142R probably damaging Het
Smox G A 2: 131,512,059 R17H possibly damaging Het
Trpm7 A T 2: 126,816,799 C1146S probably damaging Het
Upf3a C T 8: 13,791,930 A155V probably benign Het
Vmn1r212 A T 13: 22,883,911 V84D probably damaging Het
Vmn2r40 T C 7: 8,920,106 N419D probably damaging Het
Wdr92 T C 11: 17,232,790 V317A probably benign Het
Zfp143 C A 7: 110,080,351 probably benign Het
Zmat4 T A 8: 23,902,048 C7S probably damaging Het
Other mutations in Gpr37l1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00498:Gpr37l1 APN 1 135161702 splice site probably benign
IGL01362:Gpr37l1 APN 1 135161478 missense probably benign 0.00
IGL02394:Gpr37l1 APN 1 135167008 missense probably damaging 1.00
ventura UTSW 1 135161184 missense probably damaging 1.00
R0045:Gpr37l1 UTSW 1 135161145 missense probably damaging 1.00
R1199:Gpr37l1 UTSW 1 135166972 missense probably damaging 1.00
R1730:Gpr37l1 UTSW 1 135161530 nonsense probably null
R1733:Gpr37l1 UTSW 1 135161535 missense possibly damaging 0.62
R1755:Gpr37l1 UTSW 1 135166901 missense probably damaging 1.00
R3930:Gpr37l1 UTSW 1 135161362 missense probably benign 0.01
R4091:Gpr37l1 UTSW 1 135161563 missense probably benign 0.25
R4111:Gpr37l1 UTSW 1 135167270 missense possibly damaging 0.69
R4288:Gpr37l1 UTSW 1 135161184 missense probably damaging 1.00
R4739:Gpr37l1 UTSW 1 135167045 missense probably damaging 0.99
R5114:Gpr37l1 UTSW 1 135166938 missense probably damaging 1.00
R6765:Gpr37l1 UTSW 1 135167122 missense probably damaging 1.00
Posted On2014-01-21