Incidental Mutation 'IGL01679:Zfp655'
ID103741
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Zfp655
Ensembl Gene ENSMUSG00000007812
Gene Namezinc finger protein 655
Synonyms9030409O18Rik, 2700038I16Rik
Accession Numbers
Is this an essential gene? Possibly non essential (E-score: 0.449) question?
Stock #IGL01679
Quality Score
Status
Chromosome5
Chromosomal Location145231715-145247302 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to G at 145243827 bp
ZygosityHeterozygous
Amino Acid Change Glutamic Acid to Glycine at position 165 (E165G)
Ref Sequence ENSEMBL: ENSMUSP00000128969 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000167316] [ENSMUST00000199322]
Predicted Effect probably damaging
Transcript: ENSMUST00000167316
AA Change: E165G

PolyPhen 2 Score 0.964 (Sensitivity: 0.78; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000128969
Gene: ENSMUSG00000007812
AA Change: E165G

DomainStartEndE-ValueType
ZnF_C2H2 243 265 5.29e-5 SMART
ZnF_C2H2 271 293 2.99e-4 SMART
ZnF_C2H2 299 328 1.38e2 SMART
ZnF_C2H2 334 356 6.78e-3 SMART
ZnF_C2H2 361 383 3.99e0 SMART
ZnF_C2H2 411 433 3.63e-3 SMART
ZnF_C2H2 439 461 1.01e-1 SMART
low complexity region 463 475 N/A INTRINSIC
ZnF_C2H2 495 517 6.47e1 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000199322
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a zinc finger protein. The zinc finger proteins are involved in DNA binding and protein-protein interactions. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 24 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca13 T A 11: 9,298,071 M2606K probably benign Het
Abl2 A G 1: 156,642,465 I1100V probably benign Het
Atp2a1 T C 7: 126,456,809 N280S probably benign Het
Car8 G A 4: 8,169,674 T278I possibly damaging Het
Catsperb G A 12: 101,591,582 probably null Het
Cmya5 T C 13: 93,065,320 E3378G probably damaging Het
Ctsq C T 13: 61,038,908 G94D probably benign Het
Entpd8 A G 2: 25,084,366 K388E probably benign Het
Gab1 C T 8: 80,791,549 A145T probably benign Het
Gbp9 T C 5: 105,085,172 probably null Het
Gm6685 T C 11: 28,339,586 T77A possibly damaging Het
Gm8787 A G X: 79,332,833 Y266H probably damaging Het
Ick T C 9: 78,140,025 I69T possibly damaging Het
Miga2 A G 2: 30,378,250 K387R probably benign Het
Myo1g A G 11: 6,518,006 V143A possibly damaging Het
Pi4ka A G 16: 17,296,888 probably benign Het
Plekhg6 T C 6: 125,374,979 T201A probably benign Het
Pxdn T C 12: 29,999,902 S650P probably damaging Het
Rplp2 T G 7: 141,448,766 I55S probably damaging Het
Sdk1 A G 5: 142,046,164 D998G probably benign Het
Slc13a2 C A 11: 78,404,711 A110S probably damaging Het
Slc38a2 A T 15: 96,697,954 Y94* probably null Het
Smarcc1 A G 9: 110,213,530 R889G probably damaging Het
Tie1 T C 4: 118,482,739 T364A probably benign Het
Other mutations in Zfp655
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00639:Zfp655 APN 5 145244145 missense probably damaging 1.00
IGL02379:Zfp655 APN 5 145243955 missense probably benign 0.13
IGL02647:Zfp655 APN 5 145243006 missense probably benign
R0104:Zfp655 UTSW 5 145244015 missense probably damaging 1.00
R0104:Zfp655 UTSW 5 145244015 missense probably damaging 1.00
R0270:Zfp655 UTSW 5 145244457 missense probably damaging 1.00
R0608:Zfp655 UTSW 5 145244057 missense possibly damaging 0.57
R1528:Zfp655 UTSW 5 145244601 missense probably damaging 0.98
R2076:Zfp655 UTSW 5 145244600 missense possibly damaging 0.89
R2119:Zfp655 UTSW 5 145244784 missense probably damaging 0.98
R2375:Zfp655 UTSW 5 145244396 missense probably benign 0.10
R2403:Zfp655 UTSW 5 145244546 missense probably benign 0.00
R4032:Zfp655 UTSW 5 145244048 missense possibly damaging 0.50
R4532:Zfp655 UTSW 5 145244697 missense probably benign 0.06
R4880:Zfp655 UTSW 5 145244358 missense probably damaging 0.99
R5484:Zfp655 UTSW 5 145243635 missense probably benign 0.01
R5529:Zfp655 UTSW 5 145244736 missense probably damaging 0.96
R6193:Zfp655 UTSW 5 145244776 missense probably benign 0.03
R6195:Zfp655 UTSW 5 145243762 missense possibly damaging 0.52
R7050:Zfp655 UTSW 5 145244735 missense probably benign 0.12
R7471:Zfp655 UTSW 5 145244732 missense possibly damaging 0.80
R7612:Zfp655 UTSW 5 145237189 missense unknown
R7626:Zfp655 UTSW 5 145237107 missense probably damaging 1.00
R7989:Zfp655 UTSW 5 145244570 missense probably damaging 1.00
R8557:Zfp655 UTSW 5 145244025 missense probably benign 0.37
R8805:Zfp655 UTSW 5 145244480 missense probably damaging 1.00
Z1176:Zfp655 UTSW 5 145244003 missense probably damaging 1.00
Posted On2014-01-21