Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01679:Gbp9'

103750

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Gbp9

Ensembl Gene

ENSMUSG00000029298

Gene Name

guanylate-binding protein 9

Synonyms

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.054) question?

Stock #

IGL01679

Quality Score

Status

Chromosome

Chromosomal Location

105224332-105258255 bp(-) (GRCm39)

Type of Mutation

splice site

DNA Base Change (assembly)

T to C at 105233038 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000098521 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000031235] [ENSMUST00000031238] [ENSMUST00000100961]

AlphaFold

Q8BTS3

Predicted Effect

probably benign
Transcript: ENSMUST00000031235

SMART Domains

Protein: ENSMUSP00000031235
Gene: ENSMUSG00000034438

Domain	Start	End	E-Value	Type
Pfam:GBP	16	213	5.4e-91	PFAM
Pfam:GBP_C	206	493	1e-115	PFAM

Predicted Effect

probably null
Transcript: ENSMUST00000031238

SMART Domains

Protein: ENSMUSP00000031238
Gene: ENSMUSG00000029298

Domain	Start	End	E-Value	Type
Pfam:GBP	16	279	1.2e-117	PFAM
Pfam:GBP_C	281	575	4.5e-115	PFAM

Predicted Effect

probably null
Transcript: ENSMUST00000100961

SMART Domains

Protein: ENSMUSP00000098521
Gene: ENSMUSG00000029298

Domain	Start	End	E-Value	Type
Pfam:GBP	16	279	3.8e-124	PFAM
Pfam:GBP_C	281	575	4.5e-115	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000196820

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000199453

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 24 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abca13	T	A	11: 9,248,071 (GRCm39)	M2606K	probably benign	Het
Abl2	A	G	1: 156,470,035 (GRCm39)	I1100V	probably benign	Het
Atp2a1	T	C	7: 126,055,981 (GRCm39)	N280S	probably benign	Het
Car8	G	A	4: 8,169,674 (GRCm39)	T278I	possibly damaging	Het
Catsperb	G	A	12: 101,557,841 (GRCm39)		probably null	Het
Cfap47	A	G	X: 78,376,439 (GRCm39)	Y266H	probably damaging	Het
Cilk1	T	C	9: 78,047,307 (GRCm39)	I69T	possibly damaging	Het
Cmya5	T	C	13: 93,201,828 (GRCm39)	E3378G	probably damaging	Het
Ctsq	C	T	13: 61,186,722 (GRCm39)	G94D	probably benign	Het
Entpd8	A	G	2: 24,974,378 (GRCm39)	K388E	probably benign	Het
Gab1	C	T	8: 81,518,178 (GRCm39)	A145T	probably benign	Het
Gm6685	T	C	11: 28,289,586 (GRCm39)	T77A	possibly damaging	Het
Miga2	A	G	2: 30,268,262 (GRCm39)	K387R	probably benign	Het
Myo1g	A	G	11: 6,468,006 (GRCm39)	V143A	possibly damaging	Het
Pi4ka	A	G	16: 17,114,752 (GRCm39)		probably benign	Het
Plekhg6	T	C	6: 125,351,942 (GRCm39)	T201A	probably benign	Het
Pxdn	T	C	12: 30,049,901 (GRCm39)	S650P	probably damaging	Het
Rplp2	T	G	7: 141,028,679 (GRCm39)	I55S	probably damaging	Het
Sdk1	A	G	5: 142,031,919 (GRCm39)	D998G	probably benign	Het
Slc13a2	C	A	11: 78,295,537 (GRCm39)	A110S	probably damaging	Het
Slc38a2	A	T	15: 96,595,835 (GRCm39)	Y94*	probably null	Het
Smarcc1	A	G	9: 110,042,598 (GRCm39)	R889G	probably damaging	Het
Tie1	T	C	4: 118,339,936 (GRCm39)	T364A	probably benign	Het
Zfp655	A	G	5: 145,180,637 (GRCm39)	E165G	probably damaging	Het

Other mutations in Gbp9

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00094:Gbp9	APN	5	105,229,130 (GRCm39)	missense	probably benign	0.01
IGL00419:Gbp9	APN	5	105,241,943 (GRCm39)	missense	probably benign	0.05
IGL00425:Gbp9	APN	5	105,253,620 (GRCm39)	missense	possibly damaging	0.82
IGL00597:Gbp9	APN	5	105,242,364 (GRCm39)	missense	probably damaging	1.00
IGL01362:Gbp9	APN	5	105,228,072 (GRCm39)	missense	probably damaging	1.00
IGL01803:Gbp9	APN	5	105,232,884 (GRCm39)	missense	probably damaging	0.99
IGL01803:Gbp9	APN	5	105,242,039 (GRCm39)	missense	probably damaging	1.00
IGL02054:Gbp9	APN	5	105,230,673 (GRCm39)	missense	probably benign	0.12
IGL02474:Gbp9	APN	5	105,242,433 (GRCm39)	splice site	probably benign
IGL02633:Gbp9	APN	5	105,231,431 (GRCm39)	splice site	probably benign
IGL02666:Gbp9	APN	5	105,242,141 (GRCm39)	splice site	probably null
IGL02689:Gbp9	APN	5	105,253,662 (GRCm39)	missense	probably benign	0.11
IGL02812:Gbp9	APN	5	105,231,624 (GRCm39)	missense	probably damaging	1.00
IGL03132:Gbp9	APN	5	105,232,819 (GRCm39)	missense	possibly damaging	0.83
IGL03274:Gbp9	APN	5	105,230,652 (GRCm39)	missense	possibly damaging	0.58
R0410:Gbp9	UTSW	5	105,232,939 (GRCm39)	missense	probably benign	0.17
R1018:Gbp9	UTSW	5	105,228,126 (GRCm39)	missense	probably benign	0.15
R1479:Gbp9	UTSW	5	105,241,930 (GRCm39)	splice site	probably benign
R1655:Gbp9	UTSW	5	105,229,558 (GRCm39)	missense	possibly damaging	0.76
R1658:Gbp9	UTSW	5	105,242,334 (GRCm39)	missense	probably damaging	0.98
R1757:Gbp9	UTSW	5	105,242,319 (GRCm39)	missense	probably damaging	1.00
R1950:Gbp9	UTSW	5	105,229,112 (GRCm39)	missense	probably benign	0.01
R1986:Gbp9	UTSW	5	105,253,652 (GRCm39)	missense	probably damaging	0.98
R1986:Gbp9	UTSW	5	105,253,590 (GRCm39)	missense	probably damaging	1.00
R2124:Gbp9	UTSW	5	105,242,409 (GRCm39)	missense	probably damaging	1.00
R2302:Gbp9	UTSW	5	105,241,958 (GRCm39)	missense	possibly damaging	0.47
R2378:Gbp9	UTSW	5	105,228,042 (GRCm39)	missense	probably benign	0.02
R2997:Gbp9	UTSW	5	105,230,635 (GRCm39)	missense	probably benign	0.00
R3745:Gbp9	UTSW	5	105,253,724 (GRCm39)	start gained	probably benign
R4182:Gbp9	UTSW	5	105,231,461 (GRCm39)	missense	probably benign	0.08
R4485:Gbp9	UTSW	5	105,231,674 (GRCm39)	missense	probably damaging	0.97
R4718:Gbp9	UTSW	5	105,231,624 (GRCm39)	missense	probably damaging	1.00
R5063:Gbp9	UTSW	5	105,233,028 (GRCm39)	missense	probably benign
R5099:Gbp9	UTSW	5	105,242,379 (GRCm39)	missense	probably damaging	1.00
R5104:Gbp9	UTSW	5	105,228,007 (GRCm39)	missense	probably benign	0.00
R5199:Gbp9	UTSW	5	105,231,678 (GRCm39)	missense	probably benign	0.04
R5712:Gbp9	UTSW	5	105,242,421 (GRCm39)	missense	possibly damaging	0.80
R5751:Gbp9	UTSW	5	105,229,124 (GRCm39)	missense	probably benign	0.06
R5895:Gbp9	UTSW	5	105,230,724 (GRCm39)	missense	probably damaging	1.00
R6360:Gbp9	UTSW	5	105,231,596 (GRCm39)	missense	probably benign	0.03
R6646:Gbp9	UTSW	5	105,230,769 (GRCm39)	missense	probably benign	0.13
R7559:Gbp9	UTSW	5	105,232,975 (GRCm39)	missense	probably damaging	1.00
R7819:Gbp9	UTSW	5	105,251,745 (GRCm39)	missense	possibly damaging	0.65
R8042:Gbp9	UTSW	5	105,242,108 (GRCm39)	missense	probably damaging	1.00
R8288:Gbp9	UTSW	5	105,253,599 (GRCm39)	missense	probably damaging	1.00
R8303:Gbp9	UTSW	5	105,229,171 (GRCm39)	missense	possibly damaging	0.94
R8354:Gbp9	UTSW	5	105,242,027 (GRCm39)	missense	probably damaging	0.97
R8395:Gbp9	UTSW	5	105,228,069 (GRCm39)	missense	probably damaging	1.00
R8397:Gbp9	UTSW	5	105,231,464 (GRCm39)	missense	possibly damaging	0.94
R8751:Gbp9	UTSW	5	105,229,117 (GRCm39)	missense	possibly damaging	0.49
R8808:Gbp9	UTSW	5	105,232,875 (GRCm39)	missense	probably damaging	1.00
R9105:Gbp9	UTSW	5	105,241,942 (GRCm39)	missense	probably benign	0.11
R9116:Gbp9	UTSW	5	105,231,695 (GRCm39)	missense
R9354:Gbp9	UTSW	5	105,232,825 (GRCm39)	missense	possibly damaging	0.79
R9513:Gbp9	UTSW	5	105,229,091 (GRCm39)	missense	probably benign	0.06
R9709:Gbp9	UTSW	5	105,231,542 (GRCm39)	missense	probably damaging	0.99
R9717:Gbp9	UTSW	5	105,253,587 (GRCm39)	nonsense	probably null
Z1088:Gbp9	UTSW	5	105,241,991 (GRCm39)	missense	probably damaging	1.00

Posted On

2014-01-21