Incidental Mutation 'IGL01680:Map3k9'
ID 103771
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Map3k9
Ensembl Gene ENSMUSG00000042724
Gene Name mitogen-activated protein kinase kinase kinase 9
Synonyms Mlk1
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # IGL01680
Quality Score
Status
Chromosome 12
Chromosomal Location 81767784-81827949 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 81771513 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Alanine at position 715 (T715A)
Ref Sequence ENSEMBL: ENSMUSP00000152201 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000035987] [ENSMUST00000222322]
AlphaFold Q3U1V8
Predicted Effect probably benign
Transcript: ENSMUST00000035987
AA Change: T692A

PolyPhen 2 Score 0.028 (Sensitivity: 0.95; Specificity: 0.81)
SMART Domains Protein: ENSMUSP00000041819
Gene: ENSMUSG00000042724
AA Change: T692A

DomainStartEndE-ValueType
low complexity region 14 40 N/A INTRINSIC
SH3 48 108 1.61e-20 SMART
TyrKc 137 396 6.72e-89 SMART
low complexity region 449 469 N/A INTRINSIC
low complexity region 573 590 N/A INTRINSIC
low complexity region 644 657 N/A INTRINSIC
low complexity region 722 736 N/A INTRINSIC
low complexity region 749 765 N/A INTRINSIC
low complexity region 772 783 N/A INTRINSIC
low complexity region 799 811 N/A INTRINSIC
low complexity region 901 915 N/A INTRINSIC
low complexity region 1020 1036 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000221438
Predicted Effect probably benign
Transcript: ENSMUST00000222322
AA Change: T715A

PolyPhen 2 Score 0.104 (Sensitivity: 0.93; Specificity: 0.86)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000223292
Coding Region Coverage
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice homozygous for a reporter/null allele exhibit normal development, reproduction and lifespan. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 37 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adgre1 T C 17: 57,709,620 (GRCm39) W121R unknown Het
Adprh C T 16: 38,270,578 (GRCm39) G76S possibly damaging Het
Arhgap31 T C 16: 38,423,976 (GRCm39) T697A probably benign Het
Ces2f T C 8: 105,680,705 (GRCm39) M489T probably benign Het
Clec5a A G 6: 40,561,314 (GRCm39) Y44H probably benign Het
Csmd3 T C 15: 47,833,426 (GRCm39) H950R probably damaging Het
Dennd10 A G 19: 60,805,972 (GRCm39) T86A possibly damaging Het
Dgkz G T 2: 91,766,210 (GRCm39) P784T probably benign Het
Dok1 T C 6: 83,008,293 (GRCm39) D463G possibly damaging Het
Eif4a2 C A 16: 22,927,941 (GRCm39) Q94K probably benign Het
Epg5 T C 18: 78,055,956 (GRCm39) L1710P probably damaging Het
Fign A G 2: 63,808,988 (GRCm39) probably benign Het
Gbp10 T C 5: 105,372,137 (GRCm39) probably null Het
Gga2 G T 7: 121,597,299 (GRCm39) D363E probably benign Het
Glis2 T A 16: 4,429,195 (GRCm39) F133I possibly damaging Het
Isg20 A G 7: 78,566,333 (GRCm39) D94G probably damaging Het
Kif23 T C 9: 61,839,096 (GRCm39) D319G probably benign Het
Lbr C A 1: 181,663,759 (GRCm39) R87L probably damaging Het
Mapk14 T C 17: 28,944,820 (GRCm39) probably null Het
Mpp4 A C 1: 59,169,226 (GRCm39) C341W probably benign Het
Mroh9 C T 1: 162,875,551 (GRCm39) probably null Het
Myo16 T C 8: 10,322,630 (GRCm39) V20A probably damaging Het
Or12e8 T C 2: 87,188,249 (GRCm39) S154P probably damaging Het
Or52p2 A T 7: 102,237,436 (GRCm39) C171* probably null Het
Or7c19 A T 8: 85,957,308 (GRCm39) L61F probably benign Het
Pofut2 C T 10: 77,099,127 (GRCm39) R186W probably damaging Het
Ppp1r1b T A 11: 98,241,392 (GRCm39) probably null Het
Slc34a2 A G 5: 53,218,218 (GRCm39) I166V probably damaging Het
Slc4a2 A G 5: 24,637,928 (GRCm39) T375A probably benign Het
Slitrk5 C A 14: 111,916,432 (GRCm39) H19N probably benign Het
Sptb T A 12: 76,677,456 (GRCm39) Q126L probably damaging Het
Stoml1 T C 9: 58,163,996 (GRCm39) V105A probably damaging Het
Stt3b C A 9: 115,075,329 (GRCm39) probably benign Het
Thbs4 T C 13: 92,913,488 (GRCm39) E144G probably benign Het
Tns3 A G 11: 8,498,937 (GRCm39) Y49H probably damaging Het
Vmn2r87 C T 10: 130,315,586 (GRCm39) W160* probably null Het
Zfp647 T A 15: 76,801,968 (GRCm39) probably benign Het
Other mutations in Map3k9
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00640:Map3k9 APN 12 81,776,472 (GRCm39) missense probably benign 0.00
IGL01098:Map3k9 APN 12 81,770,928 (GRCm39) missense probably damaging 1.00
IGL01122:Map3k9 APN 12 81,778,900 (GRCm39) missense possibly damaging 0.94
IGL01997:Map3k9 APN 12 81,819,471 (GRCm39) missense probably damaging 1.00
IGL02178:Map3k9 APN 12 81,790,611 (GRCm39) missense probably damaging 1.00
IGL02724:Map3k9 APN 12 81,771,516 (GRCm39) missense probably benign
PIT4366001:Map3k9 UTSW 12 81,819,535 (GRCm39) missense possibly damaging 0.95
R0530:Map3k9 UTSW 12 81,769,256 (GRCm39) missense probably benign 0.00
R0541:Map3k9 UTSW 12 81,780,997 (GRCm39) missense possibly damaging 0.79
R0550:Map3k9 UTSW 12 81,772,555 (GRCm39) missense probably damaging 1.00
R0799:Map3k9 UTSW 12 81,769,043 (GRCm39) missense probably benign 0.27
R1730:Map3k9 UTSW 12 81,769,000 (GRCm39) missense probably damaging 0.99
R1783:Map3k9 UTSW 12 81,769,000 (GRCm39) missense probably damaging 0.99
R1859:Map3k9 UTSW 12 81,771,256 (GRCm39) missense possibly damaging 0.82
R1917:Map3k9 UTSW 12 81,827,564 (GRCm39) nonsense probably null
R3121:Map3k9 UTSW 12 81,790,698 (GRCm39) missense probably damaging 1.00
R3779:Map3k9 UTSW 12 81,790,565 (GRCm39) splice site probably benign
R3931:Map3k9 UTSW 12 81,819,691 (GRCm39) missense probably damaging 0.99
R3951:Map3k9 UTSW 12 81,769,295 (GRCm39) missense probably benign
R4571:Map3k9 UTSW 12 81,780,865 (GRCm39) missense probably benign 0.25
R4728:Map3k9 UTSW 12 81,769,147 (GRCm39) missense probably damaging 0.96
R4857:Map3k9 UTSW 12 81,771,401 (GRCm39) missense probably benign 0.42
R4882:Map3k9 UTSW 12 81,770,936 (GRCm39) missense probably damaging 1.00
R5077:Map3k9 UTSW 12 81,780,851 (GRCm39) splice site probably null
R5369:Map3k9 UTSW 12 81,768,826 (GRCm39) missense probably damaging 0.98
R5418:Map3k9 UTSW 12 81,790,591 (GRCm39) nonsense probably null
R5540:Map3k9 UTSW 12 81,819,587 (GRCm39) missense probably damaging 1.00
R5567:Map3k9 UTSW 12 81,778,798 (GRCm39) missense possibly damaging 0.67
R5570:Map3k9 UTSW 12 81,778,798 (GRCm39) missense possibly damaging 0.67
R5696:Map3k9 UTSW 12 81,780,896 (GRCm39) missense probably benign 0.00
R6539:Map3k9 UTSW 12 81,778,966 (GRCm39) missense probably damaging 0.98
R6542:Map3k9 UTSW 12 81,769,028 (GRCm39) missense possibly damaging 0.91
R6816:Map3k9 UTSW 12 81,769,028 (GRCm39) missense possibly damaging 0.91
R6964:Map3k9 UTSW 12 81,819,777 (GRCm39) missense probably benign 0.00
R7027:Map3k9 UTSW 12 81,777,398 (GRCm39) missense probably benign 0.06
R7055:Map3k9 UTSW 12 81,770,982 (GRCm39) missense probably damaging 0.99
R7082:Map3k9 UTSW 12 81,771,476 (GRCm39) missense probably damaging 1.00
R7247:Map3k9 UTSW 12 81,772,604 (GRCm39) missense possibly damaging 0.65
R7424:Map3k9 UTSW 12 81,770,871 (GRCm39) missense probably benign 0.00
R7476:Map3k9 UTSW 12 81,790,582 (GRCm39) missense probably damaging 1.00
R7638:Map3k9 UTSW 12 81,771,506 (GRCm39) missense probably benign 0.00
R8098:Map3k9 UTSW 12 81,780,888 (GRCm39) missense probably damaging 0.99
R8249:Map3k9 UTSW 12 81,827,551 (GRCm39) missense unknown
R8356:Map3k9 UTSW 12 81,780,892 (GRCm39) missense probably damaging 0.98
R8397:Map3k9 UTSW 12 81,769,136 (GRCm39) missense probably benign 0.13
R8444:Map3k9 UTSW 12 81,768,970 (GRCm39) missense probably damaging 1.00
R8456:Map3k9 UTSW 12 81,780,892 (GRCm39) missense probably damaging 0.98
R9025:Map3k9 UTSW 12 81,819,507 (GRCm39) missense probably damaging 1.00
R9090:Map3k9 UTSW 12 81,769,261 (GRCm39) missense probably benign 0.05
R9097:Map3k9 UTSW 12 81,819,855 (GRCm39) missense possibly damaging 0.84
R9271:Map3k9 UTSW 12 81,769,261 (GRCm39) missense probably benign 0.05
R9419:Map3k9 UTSW 12 81,827,341 (GRCm39) missense probably damaging 1.00
R9549:Map3k9 UTSW 12 81,771,255 (GRCm39) missense probably benign 0.06
R9596:Map3k9 UTSW 12 81,777,404 (GRCm39) missense probably damaging 1.00
X0025:Map3k9 UTSW 12 81,771,186 (GRCm39) missense possibly damaging 0.58
Z1176:Map3k9 UTSW 12 81,819,556 (GRCm39) missense possibly damaging 0.76
Z1177:Map3k9 UTSW 12 81,827,620 (GRCm39) missense unknown
Z1177:Map3k9 UTSW 12 81,769,053 (GRCm39) missense probably damaging 0.99
Posted On 2014-01-21