Mutagenetix > Incidental Mutations

Incidental Mutation 'IGL01681:Kng2'

103818

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Kng2

Ensembl Gene

ENSMUSG00000060459

Gene Name

kininogen 2

Synonyms

Kininogen-II

Accession Numbers

Is this an essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL01681

Quality Score

Status

Chromosome

Chromosomal Location

22985854-23029482 bp(-) (GRCm38)

Type of Mutation

splice site

DNA Base Change (assembly)

T to A at 22997017 bp

Zygosity

Heterozygous

Amino Acid Change

Gene Model

predicted gene model for transcript(s): [ENSMUST00000039338] [ENSMUST00000100046] [ENSMUST00000115349] [ENSMUST00000160243]

Predicted Effect

probably benign
Transcript: ENSMUST00000039338

SMART Domains

Protein: ENSMUSP00000046867
Gene: ENSMUSG00000060459

Domain	Start	End	E-Value	Type
CY	18	126	3.72e-19	SMART
CY	140	248	2.57e-22	SMART
CY	262	370	2.06e-35	SMART
low complexity region	376	390	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000100046

SMART Domains

Protein: ENSMUSP00000097623
Gene: ENSMUSG00000060459

Domain	Start	End	E-Value	Type
CY	18	126	3.72e-19	SMART
CY	140	248	2.57e-22	SMART
CY	262	370	2.06e-35	SMART
low complexity region	376	390	N/A	INTRINSIC
low complexity region	478	506	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000115349

SMART Domains

Protein: ENSMUSP00000111006
Gene: ENSMUSG00000060459

Domain	Start	End	E-Value	Type
CY	18	126	3.72e-19	SMART
CY	140	248	2.57e-22	SMART
CY	262	370	2.06e-35	SMART
low complexity region	376	390	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000160243

SMART Domains

Protein: ENSMUSP00000124161
Gene: ENSMUSG00000060459

Domain	Start	End	E-Value	Type
CY	18	126	3.72e-19	SMART
Blast:CY	140	171	2e-15	BLAST

Predicted Effect

probably benign
Transcript: ENSMUST00000231872

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 32 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adnp2	T	A	18: 80,127,888	E1102V	probably damaging	Het
Appl2	T	A	10: 83,614,301	I236F	possibly damaging	Het
Asb15	C	A	6: 24,567,138	T486K	probably damaging	Het
Bsdc1	T	C	4: 129,465,348		probably null	Het
Cts8	G	T	13: 61,253,619	Q61K	probably benign	Het
Cyp2d34	C	T	15: 82,617,131		probably null	Het
Dnah12	A	G	14: 26,722,160	T575A	probably benign	Het
Dync2h1	T	C	9: 7,142,196		probably null	Het
Fam170a	A	G	18: 50,282,235	D316G	possibly damaging	Het
Gtf2h3	T	A	5: 124,594,791	L216Q	probably damaging	Het
Heatr6	T	A	11: 83,765,000	S306T	probably benign	Het
Hey2	A	G	10: 30,834,137	S207P	probably benign	Het
Lama2	C	T	10: 27,265,045	E653K	probably benign	Het
Lrrcc1	T	C	3: 14,548,226	V37A	probably benign	Het
Neb	T	C	2: 52,201,486	D5085G	probably damaging	Het
Nexn	T	C	3: 152,243,870	M321V	possibly damaging	Het
Nsmce3	A	G	7: 64,872,473	I149T	probably benign	Het
Oxct1	T	G	15: 4,101,844	S405A	possibly damaging	Het
Pdpr	T	A	8: 111,132,936	N703K	probably damaging	Het
Scn10a	A	T	9: 119,694,077	D83E	probably damaging	Het
Slc47a2	C	T	11: 61,338,040	A104T	probably damaging	Het
Slc4a2	A	G	5: 24,434,187	I393V	probably damaging	Het
Thoc6	A	T	17: 23,669,883	L184M	possibly damaging	Het
Tjp2	C	T	19: 24,134,849		probably null	Het
Tmem63b	A	G	17: 45,663,571	L591P	probably damaging	Het
Tnrc6b	A	G	15: 80,879,311		probably null	Het
Trmt5	G	T	12: 73,282,603		probably benign	Het
Ubap1l	T	A	9: 65,373,919	M293K	probably benign	Het
Yars	A	G	4: 129,206,142	E211G	probably damaging	Het
Zbbx	A	C	3: 75,052,478	Y595D	probably damaging	Het
Zc3h10	G	A	10: 128,545,240	Q83*	probably null	Het
Zcchc3	T	C	2: 152,414,005	N258S	probably damaging	Het

Other mutations in Kng2

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00851:Kng2	APN	16	23028830	missense	probably damaging	1.00
IGL01319:Kng2	APN	16	23028834	missense	probably damaging	0.99
IGL01469:Kng2	APN	16	22999827	missense	probably damaging	1.00
IGL01830:Kng2	APN	16	22988051	missense	probably damaging	0.97
IGL01903:Kng2	APN	16	22987790	missense	possibly damaging	0.80
IGL02146:Kng2	APN	16	22987832	missense	probably damaging	0.97
IGL02305:Kng2	APN	16	23000624	unclassified	probably benign
IGL02429:Kng2	APN	16	23012079	missense	probably damaging	0.99
FR4548:Kng2	UTSW	16	23000552	nonsense	probably null
R0020:Kng2	UTSW	16	22997296	missense	probably benign	0.02
R0047:Kng2	UTSW	16	22987563	missense	possibly damaging	0.83
R0245:Kng2	UTSW	16	23012181	splice site	probably benign
R0610:Kng2	UTSW	16	23000594	missense	possibly damaging	0.96
R0646:Kng2	UTSW	16	22987736	missense	probably benign	0.10
R0666:Kng2	UTSW	16	22997122	splice site	probably benign
R1552:Kng2	UTSW	16	22987520	missense	probably damaging	1.00
R1765:Kng2	UTSW	16	22988243	critical splice donor site	probably null
R1833:Kng2	UTSW	16	23012052	missense	possibly damaging	0.95
R1997:Kng2	UTSW	16	23024876	missense	possibly damaging	0.84
R2025:Kng2	UTSW	16	23000575	missense	probably benign	0.15
R2056:Kng2	UTSW	16	22987953	intron	probably benign
R2137:Kng2	UTSW	16	22997326	intron	probably benign
R2517:Kng2	UTSW	16	22988315	missense	probably benign	0.24
R3438:Kng2	UTSW	16	23012071	missense	probably benign	0.23
R3439:Kng2	UTSW	16	23012071	missense	probably benign	0.23
R3551:Kng2	UTSW	16	23011995	critical splice donor site	probably null
R4389:Kng2	UTSW	16	23024868	missense	possibly damaging	0.91
R4538:Kng2	UTSW	16	22988063	missense	probably benign	0.00
R4684:Kng2	UTSW	16	22987641	missense	possibly damaging	0.93
R4978:Kng2	UTSW	16	22987916	missense	probably damaging	1.00
R5658:Kng2	UTSW	16	22997020	splice site	probably null
R6074:Kng2	UTSW	16	23000596	missense	probably benign	0.03
R6216:Kng2	UTSW	16	22987593	missense	probably damaging	1.00
R6271:Kng2	UTSW	16	23003948	missense	probably benign	0.33
R6459:Kng2	UTSW	16	23012115	missense	probably damaging	1.00
R7124:Kng2	UTSW	16	23012055	missense	probably damaging	1.00
R7310:Kng2	UTSW	16	22987772	missense	probably benign	0.00
R7532:Kng2	UTSW	16	23027044	splice site	probably null
R7667:Kng2	UTSW	16	22988232	missense	probably damaging	0.99
R7787:Kng2	UTSW	16	22999848	missense	probably damaging	1.00
R8092:Kng2	UTSW	16	22987922	missense	probably benign	0.00
R8165:Kng2	UTSW	16	22987496	missense	unknown

Posted On

2014-01-21