Incidental Mutation 'IGL01681:Trmt5'
ID103819
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Trmt5
Ensembl Gene ENSMUSG00000034442
Gene NameTRM5 tRNA methyltransferase 5
Synonyms2610027O18Rik
Accession Numbers
Is this an essential gene? Probably essential (E-score: 0.958) question?
Stock #IGL01681
Quality Score
Status
Chromosome12
Chromosomal Location73280011-73286710 bp(-) (GRCm38)
Type of Mutationunclassified
DNA Base Change (assembly) G to T at 73282603 bp
ZygosityHeterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000152619 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000058139] [ENSMUST00000101313] [ENSMUST00000116420] [ENSMUST00000122920] [ENSMUST00000126488] [ENSMUST00000140523] [ENSMUST00000153941] [ENSMUST00000220701] [ENSMUST00000221189]
Predicted Effect probably benign
Transcript: ENSMUST00000058139
SMART Domains Protein: ENSMUSP00000057153
Gene: ENSMUSG00000044712

DomainStartEndE-ValueType
Pfam:Aa_trans 44 122 9.5e-14 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000101313
SMART Domains Protein: ENSMUSP00000098871
Gene: ENSMUSG00000044712

DomainStartEndE-ValueType
Pfam:Aa_trans 1 69 4.3e-13 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000116420
SMART Domains Protein: ENSMUSP00000112121
Gene: ENSMUSG00000034442

DomainStartEndE-ValueType
Pfam:Met_10 191 412 4.5e-65 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000122920
SMART Domains Protein: ENSMUSP00000124386
Gene: ENSMUSG00000044712

DomainStartEndE-ValueType
Pfam:Aa_trans 44 113 3.5e-14 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000126488
SMART Domains Protein: ENSMUSP00000118374
Gene: ENSMUSG00000044712

DomainStartEndE-ValueType
Pfam:Aa_trans 44 122 9.5e-14 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000140523
SMART Domains Protein: ENSMUSP00000120810
Gene: ENSMUSG00000044712

DomainStartEndE-ValueType
Pfam:Aa_trans 44 452 2.5e-77 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000153941
SMART Domains Protein: ENSMUSP00000114870
Gene: ENSMUSG00000044712

DomainStartEndE-ValueType
Pfam:Aa_trans 44 124 1.6e-15 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000220701
Predicted Effect probably benign
Transcript: ENSMUST00000221189
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] tRNAs contain as many as 13 or 14 nucleotides that are modified posttranscriptionally by enzymes that are highly specific for particular nucleotides in the tRNA structure. TRMT5 methylates the N1 position of guanosine-37 (G37) in selected tRNAs using S-adenosyl methionine (Brule et al., 2004 [PubMed 15248782]).[supplied by OMIM, Mar 2008]
Allele List at MGI
Other mutations in this stock
Total: 32 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adnp2 T A 18: 80,127,888 E1102V probably damaging Het
Appl2 T A 10: 83,614,301 I236F possibly damaging Het
Asb15 C A 6: 24,567,138 T486K probably damaging Het
Bsdc1 T C 4: 129,465,348 probably null Het
Cts8 G T 13: 61,253,619 Q61K probably benign Het
Cyp2d34 C T 15: 82,617,131 probably null Het
Dnah12 A G 14: 26,722,160 T575A probably benign Het
Dync2h1 T C 9: 7,142,196 probably null Het
Fam170a A G 18: 50,282,235 D316G possibly damaging Het
Gtf2h3 T A 5: 124,594,791 L216Q probably damaging Het
Heatr6 T A 11: 83,765,000 S306T probably benign Het
Hey2 A G 10: 30,834,137 S207P probably benign Het
Kng2 T A 16: 22,997,017 probably benign Het
Lama2 C T 10: 27,265,045 E653K probably benign Het
Lrrcc1 T C 3: 14,548,226 V37A probably benign Het
Neb T C 2: 52,201,486 D5085G probably damaging Het
Nexn T C 3: 152,243,870 M321V possibly damaging Het
Nsmce3 A G 7: 64,872,473 I149T probably benign Het
Oxct1 T G 15: 4,101,844 S405A possibly damaging Het
Pdpr T A 8: 111,132,936 N703K probably damaging Het
Scn10a A T 9: 119,694,077 D83E probably damaging Het
Slc47a2 C T 11: 61,338,040 A104T probably damaging Het
Slc4a2 A G 5: 24,434,187 I393V probably damaging Het
Thoc6 A T 17: 23,669,883 L184M possibly damaging Het
Tjp2 C T 19: 24,134,849 probably null Het
Tmem63b A G 17: 45,663,571 L591P probably damaging Het
Tnrc6b A G 15: 80,879,311 probably null Het
Ubap1l T A 9: 65,373,919 M293K probably benign Het
Yars A G 4: 129,206,142 E211G probably damaging Het
Zbbx A C 3: 75,052,478 Y595D probably damaging Het
Zc3h10 G A 10: 128,545,240 Q83* probably null Het
Zcchc3 T C 2: 152,414,005 N258S probably damaging Het
Other mutations in Trmt5
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00539:Trmt5 APN 12 73284919 missense possibly damaging 0.80
IGL01468:Trmt5 APN 12 73281104 missense probably benign 0.08
IGL02502:Trmt5 APN 12 73281227 missense probably benign 0.06
IGL02627:Trmt5 APN 12 73281455 missense probably damaging 1.00
IGL02688:Trmt5 APN 12 73281458 nonsense probably null
IGL03390:Trmt5 APN 12 73282727 missense probably benign 0.30
IGL03391:Trmt5 APN 12 73281452 missense probably benign 0.00
R2068:Trmt5 UTSW 12 73284670 unclassified probably null
R2239:Trmt5 UTSW 12 73285114 missense probably benign 0.00
R2380:Trmt5 UTSW 12 73285114 missense probably benign 0.00
R5169:Trmt5 UTSW 12 73282721 missense probably damaging 1.00
R5578:Trmt5 UTSW 12 73285063 unclassified probably null
R5579:Trmt5 UTSW 12 73281652 missense possibly damaging 0.92
R7390:Trmt5 UTSW 12 73281620 missense probably damaging 1.00
Posted On2014-01-21