Incidental Mutation 'IGL01682:Trav3-1'
ID103823
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Trav3-1
Ensembl Gene ENSMUSG00000076760
Gene NameT cell receptor alpha variable 3-1
Synonyms
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.060) question?
Stock #IGL01682
Quality Score
Status
Chromosome14
Chromosomal Location52580762-52581213 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) G to A at 52581192 bp
ZygosityHeterozygous
Amino Acid Change Valine to Methionine at position 108 (V108M)
Ref Sequence ENSEMBL: ENSMUSP00000100346 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000103569]
Predicted Effect probably benign
Transcript: ENSMUST00000103569
AA Change: V108M

PolyPhen 2 Score 0.089 (Sensitivity: 0.93; Specificity: 0.85)
SMART Domains Protein: ENSMUSP00000100346
Gene: ENSMUSG00000076760
AA Change: V108M

DomainStartEndE-ValueType
IGv 39 113 6.02e-7 SMART
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 30 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Agmo T C 12: 37,357,627 probably benign Het
Atp2c1 C T 9: 105,452,842 G93D probably damaging Het
C2cd6 T G 1: 59,062,501 Y333S probably damaging Het
Cacna1a A G 8: 84,536,438 E414G possibly damaging Het
Capn10 C A 1: 92,940,384 T191K probably benign Het
Cd226 A T 18: 89,269,063 R328S probably damaging Het
Cdk10 A G 8: 123,227,658 probably null Het
Cyp4a31 T A 4: 115,578,031 V486D probably damaging Het
Dgke A T 11: 89,052,441 L241I probably damaging Het
Dnah6 G T 6: 73,075,802 A2965E probably damaging Het
Fbn2 A T 18: 58,072,671 C1112S probably damaging Het
Gm10228 T A 16: 89,041,185 Y77F unknown Het
Gng3 T C 19: 8,838,580 I25V probably benign Het
Gramd2 A G 9: 59,712,110 I61M possibly damaging Het
Hcar2 T C 5: 123,864,519 N307S probably benign Het
Iars G A 13: 49,709,658 E529K probably damaging Het
Ilvbl C T 10: 78,577,107 probably benign Het
Lrp1 T C 10: 127,574,978 K1447R probably benign Het
Mmp20 A G 9: 7,671,375 D426G probably benign Het
Muc4 G A 16: 32,754,086 G1321R probably benign Het
Olfr1289 G A 2: 111,483,843 G138S probably damaging Het
Olfr568 C T 7: 102,877,233 L38F probably benign Het
Pip4k2a A G 2: 18,997,968 S10P probably benign Het
Pth1r A T 9: 110,723,706 probably null Het
Rprd1b T C 2: 158,050,160 I201T probably damaging Het
Rsbn1 A G 3: 103,962,380 N719S probably benign Het
Sorcs1 C T 19: 50,181,506 G939E probably benign Het
Ssfa2 A G 2: 79,635,637 Q33R probably damaging Het
St8sia5 A G 18: 77,248,500 K210E probably damaging Het
Washc4 T C 10: 83,580,306 I820T possibly damaging Het
Other mutations in Trav3-1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02628:Trav3-1 APN 14 52581094 missense probably benign 0.01
R2857:Trav3-1 UTSW 14 52581058 missense probably benign 0.07
R4162:Trav3-1 UTSW 14 52581039 missense probably damaging 1.00
R4674:Trav3-1 UTSW 14 52581003 missense possibly damaging 0.66
R5475:Trav3-1 UTSW 14 52581037 missense probably damaging 1.00
R5944:Trav3-1 UTSW 14 52580992 missense probably benign 0.00
R6472:Trav3-1 UTSW 14 52581050 missense possibly damaging 0.50
R6851:Trav3-1 UTSW 14 52580971 missense probably damaging 1.00
R7788:Trav3-1 UTSW 14 52581124 missense probably damaging 1.00
R7895:Trav3-1 UTSW 14 52581093 missense probably benign 0.02
R7978:Trav3-1 UTSW 14 52581093 missense probably benign 0.02
Posted On2014-01-21