Incidental Mutation 'IGL01682:Cyp4a31'
ID 103827
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Cyp4a31
Ensembl Gene ENSMUSG00000028712
Gene Name cytochrome P450, family 4, subfamily a, polypeptide 31
Synonyms
Accession Numbers
Essential gene? Probably non essential (E-score: 0.075) question?
Stock # IGL01682
Quality Score
Status
Chromosome 4
Chromosomal Location 115420846-115436212 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 115435228 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Aspartic acid at position 486 (V486D)
Ref Sequence ENSEMBL: ENSMUSP00000030486 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000030480] [ENSMUST00000030486]
AlphaFold F8WGU9
Predicted Effect probably benign
Transcript: ENSMUST00000030480
SMART Domains Protein: ENSMUSP00000030480
Gene: ENSMUSG00000028712

DomainStartEndE-ValueType
transmembrane domain 13 35 N/A INTRINSIC
Pfam:p450 51 415 3.6e-97 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000030486
AA Change: V486D

PolyPhen 2 Score 0.968 (Sensitivity: 0.77; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000030486
Gene: ENSMUSG00000028712
AA Change: V486D

DomainStartEndE-ValueType
transmembrane domain 10 32 N/A INTRINSIC
Pfam:p450 51 504 2.6e-134 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000119563
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 30 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Agmo T C 12: 37,407,626 (GRCm39) probably benign Het
Atp2c1 C T 9: 105,330,041 (GRCm39) G93D probably damaging Het
C2cd6 T G 1: 59,101,660 (GRCm39) Y333S probably damaging Het
Cacna1a A G 8: 85,263,067 (GRCm39) E414G possibly damaging Het
Capn10 C A 1: 92,868,106 (GRCm39) T191K probably benign Het
Cd226 A T 18: 89,287,187 (GRCm39) R328S probably damaging Het
Cdk10 A G 8: 123,954,397 (GRCm39) probably null Het
Dgke A T 11: 88,943,267 (GRCm39) L241I probably damaging Het
Dnah6 G T 6: 73,052,785 (GRCm39) A2965E probably damaging Het
Fbn2 A T 18: 58,205,743 (GRCm39) C1112S probably damaging Het
Gm10228 T A 16: 88,838,073 (GRCm39) Y77F unknown Het
Gng3 T C 19: 8,815,944 (GRCm39) I25V probably benign Het
Gramd2a A G 9: 59,619,393 (GRCm39) I61M possibly damaging Het
Hcar2 T C 5: 124,002,582 (GRCm39) N307S probably benign Het
Iars1 G A 13: 49,863,134 (GRCm39) E529K probably damaging Het
Ilvbl C T 10: 78,412,941 (GRCm39) probably benign Het
Itprid2 A G 2: 79,465,981 (GRCm39) Q33R probably damaging Het
Lrp1 T C 10: 127,410,847 (GRCm39) K1447R probably benign Het
Mmp20 A G 9: 7,671,376 (GRCm39) D426G probably benign Het
Muc4 G A 16: 32,754,086 (GRCm38) G1321R probably benign Het
Or4f4b G A 2: 111,314,188 (GRCm39) G138S probably damaging Het
Or51f2 C T 7: 102,526,440 (GRCm39) L38F probably benign Het
Pip4k2a A G 2: 19,002,779 (GRCm39) S10P probably benign Het
Pth1r A T 9: 110,552,774 (GRCm39) probably null Het
Rprd1b T C 2: 157,892,080 (GRCm39) I201T probably damaging Het
Rsbn1 A G 3: 103,869,696 (GRCm39) N719S probably benign Het
Sorcs1 C T 19: 50,169,944 (GRCm39) G939E probably benign Het
St8sia5 A G 18: 77,336,196 (GRCm39) K210E probably damaging Het
Trav3-1 G A 14: 52,818,649 (GRCm39) V108M probably benign Het
Washc4 T C 10: 83,416,170 (GRCm39) I820T possibly damaging Het
Other mutations in Cyp4a31
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00429:Cyp4a31 APN 4 115,432,171 (GRCm39) unclassified probably benign
IGL02112:Cyp4a31 APN 4 115,428,180 (GRCm39) missense probably damaging 1.00
IGL02292:Cyp4a31 APN 4 115,423,698 (GRCm39) missense probably damaging 0.98
IGL02343:Cyp4a31 APN 4 115,421,026 (GRCm39) missense probably damaging 1.00
IGL02508:Cyp4a31 APN 4 115,428,261 (GRCm39) missense probably damaging 1.00
IGL03094:Cyp4a31 APN 4 115,435,305 (GRCm39) utr 3 prime probably benign
IGL03493:Cyp4a31 APN 4 115,427,952 (GRCm39) splice site probably null
R0400:Cyp4a31 UTSW 4 115,420,915 (GRCm39) start codon destroyed probably null 1.00
R1263:Cyp4a31 UTSW 4 115,431,908 (GRCm39) missense probably benign 0.01
R1508:Cyp4a31 UTSW 4 115,422,250 (GRCm39) missense possibly damaging 0.53
R1523:Cyp4a31 UTSW 4 115,426,951 (GRCm39) missense probably benign 0.23
R1822:Cyp4a31 UTSW 4 115,423,810 (GRCm39) splice site probably null
R1832:Cyp4a31 UTSW 4 115,426,928 (GRCm39) missense probably benign
R1872:Cyp4a31 UTSW 4 115,431,933 (GRCm39) missense probably damaging 0.99
R2351:Cyp4a31 UTSW 4 115,428,510 (GRCm39) missense possibly damaging 0.95
R2426:Cyp4a31 UTSW 4 115,428,213 (GRCm39) missense probably damaging 0.98
R2993:Cyp4a31 UTSW 4 115,427,017 (GRCm39) missense probably benign 0.03
R3743:Cyp4a31 UTSW 4 115,423,716 (GRCm39) missense possibly damaging 0.95
R3812:Cyp4a31 UTSW 4 115,423,706 (GRCm39) missense probably benign
R3963:Cyp4a31 UTSW 4 115,431,969 (GRCm39) unclassified probably benign
R4211:Cyp4a31 UTSW 4 115,422,210 (GRCm39) missense probably benign 0.01
R4814:Cyp4a31 UTSW 4 115,427,466 (GRCm39) missense probably damaging 1.00
R6245:Cyp4a31 UTSW 4 115,428,545 (GRCm39) missense possibly damaging 0.91
R6255:Cyp4a31 UTSW 4 115,432,117 (GRCm39) missense possibly damaging 0.82
R6330:Cyp4a31 UTSW 4 115,421,074 (GRCm39) missense probably damaging 0.99
R6433:Cyp4a31 UTSW 4 115,427,466 (GRCm39) missense probably damaging 1.00
R6602:Cyp4a31 UTSW 4 115,426,904 (GRCm39) critical splice acceptor site probably null
R6844:Cyp4a31 UTSW 4 115,420,989 (GRCm39) missense probably null 0.00
R7154:Cyp4a31 UTSW 4 115,431,963 (GRCm39) critical splice donor site probably null
R7300:Cyp4a31 UTSW 4 115,427,468 (GRCm39) missense probably benign 0.03
R8188:Cyp4a31 UTSW 4 115,426,943 (GRCm39) missense probably benign 0.29
R8557:Cyp4a31 UTSW 4 115,427,438 (GRCm39) missense possibly damaging 0.93
R8692:Cyp4a31 UTSW 4 115,423,769 (GRCm39) missense probably damaging 0.98
R8696:Cyp4a31 UTSW 4 115,422,225 (GRCm39) missense probably benign 0.43
R8728:Cyp4a31 UTSW 4 115,422,225 (GRCm39) missense probably benign 0.43
R8753:Cyp4a31 UTSW 4 115,432,158 (GRCm39) missense probably benign 0.37
R8822:Cyp4a31 UTSW 4 115,422,225 (GRCm39) missense probably benign 0.43
R8942:Cyp4a31 UTSW 4 115,426,918 (GRCm39) missense possibly damaging 0.87
R9230:Cyp4a31 UTSW 4 115,428,281 (GRCm39) nonsense probably null
R9672:Cyp4a31 UTSW 4 115,427,422 (GRCm39) missense probably benign 0.05
X0020:Cyp4a31 UTSW 4 115,422,306 (GRCm39) missense probably benign 0.06
X0021:Cyp4a31 UTSW 4 115,435,158 (GRCm39) missense probably damaging 1.00
Posted On 2014-01-21