Incidental Mutation 'IGL01684:Vmn1r59'
| ID |
103874 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Vmn1r59
|
| Ensembl Gene |
ENSMUSG00000074401 |
| Gene Name |
vomeronasal 1 receptor 59 |
| Synonyms |
V1rd10 |
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.058)
|
| Stock # |
IGL01684
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
7 |
| Chromosomal Location |
5456826-5457758 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 5457299 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Threonine to Alanine
at position 154
(T154A)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000073768
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000074132]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000074132
AA Change: T154A
PolyPhen 2
Score 0.116 (Sensitivity: 0.93; Specificity: 0.86)
|
| SMART Domains |
Protein: ENSMUSP00000073768
Gene: ENSMUSG00000074401
AA Change: T154A
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:TAS2R
|
1 |
289 |
2e-14 |
PFAM |
|
Pfam:7tm_1
|
20 |
279 |
1.9e-6 |
PFAM |
|
Pfam:V1R
|
31 |
287 |
3e-16 |
PFAM |
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 39 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Ammecr1l |
G |
T |
18: 31,904,821 (GRCm39) |
V21F |
probably damaging |
Het |
| Aox1 |
G |
A |
1: 58,116,740 (GRCm39) |
|
probably null |
Het |
| BC024139 |
A |
G |
15: 76,008,885 (GRCm39) |
L283P |
probably damaging |
Het |
| Cacna1h |
C |
T |
17: 25,607,690 (GRCm39) |
G876S |
probably damaging |
Het |
| Ccdc66 |
T |
C |
14: 27,222,206 (GRCm39) |
E179G |
possibly damaging |
Het |
| Ckap5 |
T |
G |
2: 91,385,699 (GRCm39) |
D182E |
probably benign |
Het |
| Clk1 |
A |
G |
1: 58,456,424 (GRCm39) |
|
probably null |
Het |
| Dhx34 |
G |
A |
7: 15,937,204 (GRCm39) |
T831M |
probably damaging |
Het |
| Enox1 |
T |
C |
14: 77,816,533 (GRCm39) |
I171T |
possibly damaging |
Het |
| Fscn2 |
G |
A |
11: 120,258,131 (GRCm39) |
R351H |
probably damaging |
Het |
| Gabbr2 |
G |
A |
4: 46,736,501 (GRCm39) |
S460L |
probably benign |
Het |
| Gramd1a |
A |
G |
7: 30,838,330 (GRCm39) |
S308P |
possibly damaging |
Het |
| Guca1a |
T |
C |
17: 47,706,068 (GRCm39) |
D137G |
probably null |
Het |
| Heatr5a |
G |
A |
12: 52,002,294 (GRCm39) |
T214I |
probably benign |
Het |
| Klf7 |
T |
C |
1: 64,160,051 (GRCm39) |
|
probably benign |
Het |
| Macf1 |
A |
G |
4: 123,359,723 (GRCm39) |
S1854P |
probably damaging |
Het |
| Mau2 |
A |
T |
8: 70,481,895 (GRCm39) |
|
probably benign |
Het |
| Mdn1 |
A |
G |
4: 32,726,857 (GRCm39) |
I2639V |
probably benign |
Het |
| Mylk |
A |
G |
16: 34,792,310 (GRCm39) |
M1544V |
possibly damaging |
Het |
| Ogdh |
G |
T |
11: 6,292,546 (GRCm39) |
V420L |
probably damaging |
Het |
| Or13a21 |
T |
C |
7: 139,998,828 (GRCm39) |
N286S |
probably damaging |
Het |
| Or5b105 |
A |
G |
19: 13,080,353 (GRCm39) |
F105S |
possibly damaging |
Het |
| Pcm1 |
A |
G |
8: 41,710,960 (GRCm39) |
T77A |
probably benign |
Het |
| Piezo2 |
T |
A |
18: 63,216,241 (GRCm39) |
I947F |
probably damaging |
Het |
| Prrc2c |
A |
T |
1: 162,534,031 (GRCm39) |
|
probably benign |
Het |
| Ptch2 |
A |
G |
4: 116,961,984 (GRCm39) |
E107G |
probably damaging |
Het |
| Rmdn3 |
T |
C |
2: 118,978,055 (GRCm39) |
E182G |
probably damaging |
Het |
| Rpl23a-ps3 |
C |
T |
14: 33,892,745 (GRCm39) |
|
noncoding transcript |
Het |
| Sorl1 |
T |
C |
9: 41,892,007 (GRCm39) |
D1881G |
probably damaging |
Het |
| Tbc1d19 |
A |
G |
5: 54,014,221 (GRCm39) |
N283S |
probably benign |
Het |
| Tcf20 |
A |
G |
15: 82,741,361 (GRCm39) |
F30S |
probably damaging |
Het |
| Tiparp |
A |
T |
3: 65,460,754 (GRCm39) |
K581I |
probably damaging |
Het |
| Tle3 |
T |
C |
9: 61,310,728 (GRCm39) |
|
probably benign |
Het |
| Ubr3 |
C |
A |
2: 69,846,502 (GRCm39) |
Y1608* |
probably null |
Het |
| Vta1 |
A |
G |
10: 14,559,875 (GRCm39) |
I115T |
probably damaging |
Het |
| Wwtr1 |
C |
A |
3: 57,483,210 (GRCm39) |
R31L |
probably damaging |
Het |
| Zfp385b |
T |
C |
2: 77,550,019 (GRCm39) |
D22G |
possibly damaging |
Het |
| Zfp516 |
A |
G |
18: 82,975,326 (GRCm39) |
E508G |
probably damaging |
Het |
| Zfp735 |
T |
A |
11: 73,581,191 (GRCm39) |
V76E |
possibly damaging |
Het |
|
| Other mutations in Vmn1r59 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL02035:Vmn1r59
|
APN |
7 |
5,457,208 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
IGL02039:Vmn1r59
|
APN |
7 |
5,457,380 (GRCm39) |
missense |
probably benign |
0.23 |
|
IGL02812:Vmn1r59
|
APN |
7 |
5,457,176 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0033:Vmn1r59
|
UTSW |
7 |
5,457,433 (GRCm39) |
missense |
probably benign |
0.08 |
|
R0115:Vmn1r59
|
UTSW |
7 |
5,457,115 (GRCm39) |
missense |
probably benign |
0.07 |
|
R1164:Vmn1r59
|
UTSW |
7 |
5,457,410 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1629:Vmn1r59
|
UTSW |
7 |
5,457,466 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1845:Vmn1r59
|
UTSW |
7 |
5,457,553 (GRCm39) |
missense |
probably benign |
0.03 |
|
R1969:Vmn1r59
|
UTSW |
7 |
5,457,038 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1970:Vmn1r59
|
UTSW |
7 |
5,457,038 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1971:Vmn1r59
|
UTSW |
7 |
5,457,038 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2011:Vmn1r59
|
UTSW |
7 |
5,457,283 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3712:Vmn1r59
|
UTSW |
7 |
5,457,637 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4580:Vmn1r59
|
UTSW |
7 |
5,457,136 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4593:Vmn1r59
|
UTSW |
7 |
5,457,686 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R4697:Vmn1r59
|
UTSW |
7 |
5,457,451 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4856:Vmn1r59
|
UTSW |
7 |
5,457,532 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R4873:Vmn1r59
|
UTSW |
7 |
5,457,108 (GRCm39) |
missense |
probably benign |
|
|
R4875:Vmn1r59
|
UTSW |
7 |
5,457,108 (GRCm39) |
missense |
probably benign |
|
|
R4925:Vmn1r59
|
UTSW |
7 |
5,457,115 (GRCm39) |
missense |
probably benign |
0.07 |
|
R5319:Vmn1r59
|
UTSW |
7 |
5,457,209 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6239:Vmn1r59
|
UTSW |
7 |
5,457,539 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6533:Vmn1r59
|
UTSW |
7 |
5,457,463 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6912:Vmn1r59
|
UTSW |
7 |
5,457,599 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7023:Vmn1r59
|
UTSW |
7 |
5,457,477 (GRCm39) |
missense |
probably benign |
0.37 |
|
R7205:Vmn1r59
|
UTSW |
7 |
5,457,725 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7374:Vmn1r59
|
UTSW |
7 |
5,457,160 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7390:Vmn1r59
|
UTSW |
7 |
5,456,986 (GRCm39) |
missense |
possibly damaging |
0.59 |
|
R7776:Vmn1r59
|
UTSW |
7 |
5,457,634 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R8306:Vmn1r59
|
UTSW |
7 |
5,456,966 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8473:Vmn1r59
|
UTSW |
7 |
5,457,064 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R8499:Vmn1r59
|
UTSW |
7 |
5,457,750 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8523:Vmn1r59
|
UTSW |
7 |
5,457,053 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8706:Vmn1r59
|
UTSW |
7 |
5,457,715 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R9104:Vmn1r59
|
UTSW |
7 |
5,457,166 (GRCm39) |
missense |
probably benign |
0.00 |
|
| Posted On |
2014-01-21 |
Incidental Mutation