Incidental Mutation 'IGL01684:Vmn1r59'
ID103874
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Vmn1r59
Ensembl Gene ENSMUSG00000074401
Gene Namevomeronasal 1 receptor 59
SynonymsV1rd10
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.058) question?
Stock #IGL01684
Quality Score
Status
Chromosome7
Chromosomal Location5453400-5454838 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to C at 5454300 bp
ZygosityHeterozygous
Amino Acid Change Threonine to Alanine at position 154 (T154A)
Ref Sequence ENSEMBL: ENSMUSP00000073768 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000074132]
Predicted Effect probably benign
Transcript: ENSMUST00000074132
AA Change: T154A

PolyPhen 2 Score 0.116 (Sensitivity: 0.93; Specificity: 0.86)
SMART Domains Protein: ENSMUSP00000073768
Gene: ENSMUSG00000074401
AA Change: T154A

DomainStartEndE-ValueType
Pfam:TAS2R 1 289 2e-14 PFAM
Pfam:7tm_1 20 279 1.9e-6 PFAM
Pfam:V1R 31 287 3e-16 PFAM
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 39 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ammecr1l G T 18: 31,771,768 V21F probably damaging Het
Aox1 G A 1: 58,077,581 probably null Het
BC024139 A G 15: 76,124,685 L283P probably damaging Het
Cacna1h C T 17: 25,388,716 G876S probably damaging Het
Ccdc66 T C 14: 27,500,249 E179G possibly damaging Het
Ckap5 T G 2: 91,555,354 D182E probably benign Het
Clk1 A G 1: 58,417,265 probably null Het
Dhx34 G A 7: 16,203,279 T831M probably damaging Het
Enox1 T C 14: 77,579,093 I171T possibly damaging Het
Fscn2 G A 11: 120,367,305 R351H probably damaging Het
Gabbr2 G A 4: 46,736,501 S460L probably benign Het
Gramd1a A G 7: 31,138,905 S308P possibly damaging Het
Guca1a T C 17: 47,395,143 D137G probably null Het
Heatr5a G A 12: 51,955,511 T214I probably benign Het
Klf7 T C 1: 64,120,892 probably benign Het
Macf1 A G 4: 123,465,930 S1854P probably damaging Het
Mau2 A T 8: 70,029,245 probably benign Het
Mdn1 A G 4: 32,726,857 I2639V probably benign Het
Mylk A G 16: 34,971,940 M1544V possibly damaging Het
Ogdh G T 11: 6,342,546 V420L probably damaging Het
Olfr1458 A G 19: 13,102,989 F105S possibly damaging Het
Olfr532 T C 7: 140,418,915 N286S probably damaging Het
Pcm1 A G 8: 41,257,923 T77A probably benign Het
Piezo2 T A 18: 63,083,170 I947F probably damaging Het
Prrc2c A T 1: 162,706,462 probably benign Het
Ptch2 A G 4: 117,104,787 E107G probably damaging Het
Rmdn3 T C 2: 119,147,574 E182G probably damaging Het
Rpl23a-ps3 C T 14: 34,170,788 noncoding transcript Het
Sorl1 T C 9: 41,980,711 D1881G probably damaging Het
Tbc1d19 A G 5: 53,856,879 N283S probably benign Het
Tcf20 A G 15: 82,857,160 F30S probably damaging Het
Tiparp A T 3: 65,553,333 K581I probably damaging Het
Tle3 T C 9: 61,403,446 probably benign Het
Ubr3 C A 2: 70,016,158 Y1608* probably null Het
Vta1 A G 10: 14,684,131 I115T probably damaging Het
Wwtr1 C A 3: 57,575,789 R31L probably damaging Het
Zfp385b T C 2: 77,719,675 D22G possibly damaging Het
Zfp516 A G 18: 82,957,201 E508G probably damaging Het
Zfp735 T A 11: 73,690,365 V76E possibly damaging Het
Other mutations in Vmn1r59
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02035:Vmn1r59 APN 7 5454209 missense possibly damaging 0.87
IGL02039:Vmn1r59 APN 7 5454381 missense probably benign 0.23
IGL02812:Vmn1r59 APN 7 5454177 missense probably damaging 1.00
R0033:Vmn1r59 UTSW 7 5454434 missense probably benign 0.08
R0115:Vmn1r59 UTSW 7 5454116 missense probably benign 0.07
R1164:Vmn1r59 UTSW 7 5454411 missense probably benign 0.00
R1629:Vmn1r59 UTSW 7 5454467 missense probably damaging 1.00
R1845:Vmn1r59 UTSW 7 5454554 missense probably benign 0.03
R1969:Vmn1r59 UTSW 7 5454039 missense probably damaging 1.00
R1970:Vmn1r59 UTSW 7 5454039 missense probably damaging 1.00
R1971:Vmn1r59 UTSW 7 5454039 missense probably damaging 1.00
R2011:Vmn1r59 UTSW 7 5454284 missense probably damaging 1.00
R3712:Vmn1r59 UTSW 7 5454638 missense probably damaging 0.99
R4580:Vmn1r59 UTSW 7 5454137 missense probably damaging 0.98
R4593:Vmn1r59 UTSW 7 5454687 missense possibly damaging 0.46
R4697:Vmn1r59 UTSW 7 5454452 missense probably damaging 1.00
R4856:Vmn1r59 UTSW 7 5454533 missense possibly damaging 0.92
R4873:Vmn1r59 UTSW 7 5454109 missense probably benign
R4875:Vmn1r59 UTSW 7 5454109 missense probably benign
R4925:Vmn1r59 UTSW 7 5454116 missense probably benign 0.07
R5319:Vmn1r59 UTSW 7 5454210 missense probably damaging 0.99
R6239:Vmn1r59 UTSW 7 5454540 missense probably damaging 1.00
R6533:Vmn1r59 UTSW 7 5454464 missense probably benign 0.00
R6912:Vmn1r59 UTSW 7 5454600 missense probably benign 0.01
R7023:Vmn1r59 UTSW 7 5454478 missense probably benign 0.37
R7205:Vmn1r59 UTSW 7 5454726 missense probably damaging 1.00
R7374:Vmn1r59 UTSW 7 5454161 missense probably damaging 0.99
R7390:Vmn1r59 UTSW 7 5453987 missense possibly damaging 0.59
R7776:Vmn1r59 UTSW 7 5454635 missense probably damaging 0.97
R8306:Vmn1r59 UTSW 7 5453967 missense probably benign 0.01
R8473:Vmn1r59 UTSW 7 5454065 missense possibly damaging 0.84
R8499:Vmn1r59 UTSW 7 5454751 missense probably benign 0.00
R8523:Vmn1r59 UTSW 7 5454054 missense probably damaging 1.00
R8706:Vmn1r59 UTSW 7 5454716 missense possibly damaging 0.83
Posted On2014-01-21