Incidental Mutation 'IGL01684:Or13a21'
ID 103896
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Or13a21
Ensembl Gene ENSMUSG00000063823
Gene Name olfactory receptor family 13 subfamily A member 21
Synonyms Olfr532, GA_x6K02T2PBJ9-42570051-42569122, MOR251-1
Accession Numbers
Essential gene? Probably non essential (E-score: 0.061) question?
Stock # IGL01684
Quality Score
Status
Chromosome 7
Chromosomal Location 139998755-139999684 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 139998828 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Asparagine to Serine at position 286 (N286S)
Ref Sequence ENSEMBL: ENSMUSP00000150798 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000073226] [ENSMUST00000213801]
AlphaFold Q8VGT4
Predicted Effect probably damaging
Transcript: ENSMUST00000073226
AA Change: N286S

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000072959
Gene: ENSMUSG00000063823
AA Change: N286S

DomainStartEndE-ValueType
Pfam:7tm_4 31 307 4.7e-51 PFAM
Pfam:7TM_GPCR_Srsx 35 305 2.5e-6 PFAM
Pfam:7tm_1 41 290 1.7e-24 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000213172
Predicted Effect probably damaging
Transcript: ENSMUST00000213801
AA Change: N286S

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 39 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ammecr1l G T 18: 31,904,821 (GRCm39) V21F probably damaging Het
Aox1 G A 1: 58,116,740 (GRCm39) probably null Het
BC024139 A G 15: 76,008,885 (GRCm39) L283P probably damaging Het
Cacna1h C T 17: 25,607,690 (GRCm39) G876S probably damaging Het
Ccdc66 T C 14: 27,222,206 (GRCm39) E179G possibly damaging Het
Ckap5 T G 2: 91,385,699 (GRCm39) D182E probably benign Het
Clk1 A G 1: 58,456,424 (GRCm39) probably null Het
Dhx34 G A 7: 15,937,204 (GRCm39) T831M probably damaging Het
Enox1 T C 14: 77,816,533 (GRCm39) I171T possibly damaging Het
Fscn2 G A 11: 120,258,131 (GRCm39) R351H probably damaging Het
Gabbr2 G A 4: 46,736,501 (GRCm39) S460L probably benign Het
Gramd1a A G 7: 30,838,330 (GRCm39) S308P possibly damaging Het
Guca1a T C 17: 47,706,068 (GRCm39) D137G probably null Het
Heatr5a G A 12: 52,002,294 (GRCm39) T214I probably benign Het
Klf7 T C 1: 64,160,051 (GRCm39) probably benign Het
Macf1 A G 4: 123,359,723 (GRCm39) S1854P probably damaging Het
Mau2 A T 8: 70,481,895 (GRCm39) probably benign Het
Mdn1 A G 4: 32,726,857 (GRCm39) I2639V probably benign Het
Mylk A G 16: 34,792,310 (GRCm39) M1544V possibly damaging Het
Ogdh G T 11: 6,292,546 (GRCm39) V420L probably damaging Het
Or5b105 A G 19: 13,080,353 (GRCm39) F105S possibly damaging Het
Pcm1 A G 8: 41,710,960 (GRCm39) T77A probably benign Het
Piezo2 T A 18: 63,216,241 (GRCm39) I947F probably damaging Het
Prrc2c A T 1: 162,534,031 (GRCm39) probably benign Het
Ptch2 A G 4: 116,961,984 (GRCm39) E107G probably damaging Het
Rmdn3 T C 2: 118,978,055 (GRCm39) E182G probably damaging Het
Rpl23a-ps3 C T 14: 33,892,745 (GRCm39) noncoding transcript Het
Sorl1 T C 9: 41,892,007 (GRCm39) D1881G probably damaging Het
Tbc1d19 A G 5: 54,014,221 (GRCm39) N283S probably benign Het
Tcf20 A G 15: 82,741,361 (GRCm39) F30S probably damaging Het
Tiparp A T 3: 65,460,754 (GRCm39) K581I probably damaging Het
Tle3 T C 9: 61,310,728 (GRCm39) probably benign Het
Ubr3 C A 2: 69,846,502 (GRCm39) Y1608* probably null Het
Vmn1r59 T C 7: 5,457,299 (GRCm39) T154A probably benign Het
Vta1 A G 10: 14,559,875 (GRCm39) I115T probably damaging Het
Wwtr1 C A 3: 57,483,210 (GRCm39) R31L probably damaging Het
Zfp385b T C 2: 77,550,019 (GRCm39) D22G possibly damaging Het
Zfp516 A G 18: 82,975,326 (GRCm39) E508G probably damaging Het
Zfp735 T A 11: 73,581,191 (GRCm39) V76E possibly damaging Het
Other mutations in Or13a21
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01743:Or13a21 APN 7 139,999,581 (GRCm39) missense probably damaging 1.00
IGL01797:Or13a21 APN 7 139,998,931 (GRCm39) missense probably damaging 1.00
IGL02291:Or13a21 APN 7 139,999,200 (GRCm39) missense probably damaging 1.00
IGL02382:Or13a21 APN 7 139,999,516 (GRCm39) missense possibly damaging 0.72
IGL02514:Or13a21 APN 7 139,999,507 (GRCm39) missense probably damaging 1.00
IGL02600:Or13a21 APN 7 139,998,862 (GRCm39) missense probably benign
IGL02613:Or13a21 APN 7 139,999,383 (GRCm39) missense probably benign 0.04
R0358:Or13a21 UTSW 7 139,998,856 (GRCm39) missense probably damaging 0.98
R0827:Or13a21 UTSW 7 139,999,380 (GRCm39) missense probably damaging 0.99
R1464:Or13a21 UTSW 7 139,999,286 (GRCm39) missense probably benign 0.01
R1464:Or13a21 UTSW 7 139,999,286 (GRCm39) missense probably benign 0.01
R1539:Or13a21 UTSW 7 139,999,326 (GRCm39) missense probably benign 0.26
R1691:Or13a21 UTSW 7 139,998,855 (GRCm39) missense probably damaging 1.00
R2012:Or13a21 UTSW 7 139,999,024 (GRCm39) missense probably damaging 1.00
R2195:Or13a21 UTSW 7 139,999,138 (GRCm39) missense possibly damaging 0.49
R4519:Or13a21 UTSW 7 139,999,123 (GRCm39) missense probably damaging 1.00
R6368:Or13a21 UTSW 7 139,999,580 (GRCm39) nonsense probably null
R6656:Or13a21 UTSW 7 139,999,517 (GRCm39) missense probably damaging 0.99
R7467:Or13a21 UTSW 7 139,999,287 (GRCm39) missense probably benign
R7610:Or13a21 UTSW 7 139,999,466 (GRCm39) nonsense probably null
R7795:Or13a21 UTSW 7 139,999,027 (GRCm39) missense possibly damaging 0.49
R7837:Or13a21 UTSW 7 139,999,234 (GRCm39) missense probably benign 0.01
R8755:Or13a21 UTSW 7 139,999,417 (GRCm39) missense probably benign 0.00
R9706:Or13a21 UTSW 7 139,999,266 (GRCm39) missense probably damaging 0.96
Posted On 2014-01-21