Incidental Mutation 'IGL01686:Or14c45'
ID 103950
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Or14c45
Ensembl Gene ENSMUSG00000057067
Gene Name olfactory receptor family 14 subfamily C member 45
Synonyms Olfr297, GA_x6K02T2NHDJ-9587747-9586815, MOR220-3
Accession Numbers
Essential gene? Probably non essential (E-score: 0.053) question?
Stock # IGL01686
Quality Score
Status
Chromosome 7
Chromosomal Location 86175967-86176899 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 86175986 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Alanine at position 7 (V7A)
Ref Sequence ENSEMBL: ENSMUSP00000134371 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000071112] [ENSMUST00000172965]
AlphaFold Q7TS07
Predicted Effect probably benign
Transcript: ENSMUST00000071112
AA Change: V7A

PolyPhen 2 Score 0.102 (Sensitivity: 0.93; Specificity: 0.86)
SMART Domains Protein: ENSMUSP00000132942
Gene: ENSMUSG00000057067
AA Change: V7A

DomainStartEndE-ValueType
Pfam:7tm_4 29 305 1.9e-45 PFAM
Pfam:7tm_1 39 288 1.4e-19 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000172965
AA Change: V7A

PolyPhen 2 Score 0.102 (Sensitivity: 0.93; Specificity: 0.86)
SMART Domains Protein: ENSMUSP00000134371
Gene: ENSMUSG00000057067
AA Change: V7A

DomainStartEndE-ValueType
Pfam:7tm_4 29 305 1.2e-46 PFAM
Pfam:7tm_1 39 288 2e-20 PFAM
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 34 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcc9 A G 6: 142,548,801 (GRCm39) V1316A possibly damaging Het
Ada T G 2: 163,572,236 (GRCm39) K254N probably benign Het
Adamts17 A G 7: 66,490,037 (GRCm39) R40G probably benign Het
Akr1d1 C T 6: 37,507,178 (GRCm39) probably benign Het
Aldh1l1 T A 6: 90,536,215 (GRCm39) probably benign Het
Bbox1 T A 2: 110,095,831 (GRCm39) I378F probably benign Het
BC028528 T C 3: 95,796,212 (GRCm39) N50S probably damaging Het
Casp8ap2 T A 4: 32,641,294 (GRCm39) S783T possibly damaging Het
Cmpk2 C T 12: 26,527,177 (GRCm39) R389W probably damaging Het
Cplx1 C T 5: 108,696,393 (GRCm39) probably null Het
Crim1 T C 17: 78,651,863 (GRCm39) L529P probably benign Het
Ctps1 A G 4: 120,411,183 (GRCm39) S278P probably benign Het
Defb21 C A 2: 152,416,821 (GRCm39) probably benign Het
Ecm1 T A 3: 95,643,376 (GRCm39) N308I probably benign Het
Flg2 T C 3: 93,109,591 (GRCm39) S540P unknown Het
Gabrp G T 11: 33,502,826 (GRCm39) S346* probably null Het
Gli2 C A 1: 118,776,165 (GRCm39) C419F probably damaging Het
Grid2 T A 6: 64,297,180 (GRCm39) F514L probably benign Het
Hormad1 T G 3: 95,485,580 (GRCm39) M256R probably benign Het
Itsn2 T G 12: 4,686,693 (GRCm39) probably benign Het
Klhl38 A T 15: 58,186,707 (GRCm39) D7E probably benign Het
Map3k1 G A 13: 111,891,196 (GRCm39) T1248I possibly damaging Het
Mki67 A T 7: 135,309,542 (GRCm39) V303E probably benign Het
Mterf4 A T 1: 93,232,443 (GRCm39) L136* probably null Het
Mtmr14 A G 6: 113,217,391 (GRCm39) D61G possibly damaging Het
Nf2 A T 11: 4,768,613 (GRCm39) D85E probably benign Het
Nmnat2 G T 1: 152,952,743 (GRCm39) probably benign Het
Olfm3 T A 3: 114,916,497 (GRCm39) D476E probably benign Het
Or8b53 T A 9: 38,667,550 (GRCm39) C189S probably damaging Het
Pdia6 T C 12: 17,333,958 (GRCm39) probably benign Het
Prrg1 G A X: 77,527,388 (GRCm39) A47V probably damaging Het
Rgs22 A T 15: 36,103,981 (GRCm39) I160K probably benign Het
Sardh T C 2: 27,079,625 (GRCm39) Y889C probably damaging Het
Syne2 C A 12: 75,956,110 (GRCm39) D605E probably benign Het
Other mutations in Or14c45
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01823:Or14c45 APN 7 86,176,249 (GRCm39) missense probably damaging 1.00
PIT4378001:Or14c45 UTSW 7 86,176,306 (GRCm39) missense possibly damaging 0.50
R0304:Or14c45 UTSW 7 86,176,195 (GRCm39) missense probably damaging 1.00
R0737:Or14c45 UTSW 7 86,176,195 (GRCm39) missense probably damaging 1.00
R2177:Or14c45 UTSW 7 86,176,870 (GRCm39) missense probably benign 0.01
R2436:Or14c45 UTSW 7 86,176,591 (GRCm39) missense probably damaging 0.99
R4289:Or14c45 UTSW 7 86,176,262 (GRCm39) missense probably damaging 1.00
R4639:Or14c45 UTSW 7 86,175,969 (GRCm39) start codon destroyed probably null 1.00
R5202:Or14c45 UTSW 7 86,176,324 (GRCm39) missense probably damaging 1.00
R5782:Or14c45 UTSW 7 86,176,421 (GRCm39) missense probably damaging 0.98
R6446:Or14c45 UTSW 7 86,176,310 (GRCm39) missense possibly damaging 0.90
R6615:Or14c45 UTSW 7 86,176,120 (GRCm39) missense probably benign 0.06
R6920:Or14c45 UTSW 7 86,176,522 (GRCm39) missense probably benign 0.00
R7150:Or14c45 UTSW 7 86,176,322 (GRCm39) missense probably damaging 1.00
R7309:Or14c45 UTSW 7 86,176,349 (GRCm39) missense probably damaging 1.00
R7621:Or14c45 UTSW 7 86,176,280 (GRCm39) missense probably benign 0.37
R8257:Or14c45 UTSW 7 86,176,678 (GRCm39) missense possibly damaging 0.95
R9349:Or14c45 UTSW 7 86,176,373 (GRCm39) missense probably benign 0.01
R9466:Or14c45 UTSW 7 86,176,080 (GRCm39) missense probably benign
R9479:Or14c45 UTSW 7 86,176,285 (GRCm39) missense possibly damaging 0.81
Posted On 2014-01-21