Incidental Mutation 'IGL01687:Zfp871'
| ID |
103994 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Zfp871
|
| Ensembl Gene |
ENSMUSG00000024298 |
| Gene Name |
zinc finger protein 871 |
| Synonyms |
9030612M13Rik |
| Accession Numbers |
|
| Essential gene? |
Essential
(E-score: 1.000)
|
| Stock # |
IGL01687
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
17 |
| Chromosomal Location |
32984470-33007261 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to A
at 32994618 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Threonine to Serine
at position 167
(T167S)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000050501
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000057501]
[ENSMUST00000159086]
|
| AlphaFold |
G5E905 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000057501
AA Change: T167S
PolyPhen 2
Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)
|
| SMART Domains |
Protein: ENSMUSP00000050501
Gene: ENSMUSG00000024298
AA Change: T167S
| Domain | Start | End | E-Value | Type |
|---|
|
KRAB
|
1 |
42 |
1.32e0 |
SMART |
|
ZnF_C2H2
|
174 |
196 |
5.9e-3 |
SMART |
|
ZnF_C2H2
|
202 |
224 |
6.32e-3 |
SMART |
|
ZnF_C2H2
|
230 |
252 |
1.47e-3 |
SMART |
|
ZnF_C2H2
|
258 |
280 |
3.63e-3 |
SMART |
|
ZnF_C2H2
|
286 |
308 |
1.79e-2 |
SMART |
|
ZnF_C2H2
|
314 |
336 |
4.79e-3 |
SMART |
|
ZnF_C2H2
|
342 |
364 |
1.69e-3 |
SMART |
|
ZnF_C2H2
|
370 |
392 |
2.79e-4 |
SMART |
|
ZnF_C2H2
|
398 |
420 |
1.23e-5 |
SMART |
|
ZnF_C2H2
|
426 |
448 |
1.2e-3 |
SMART |
|
ZnF_C2H2
|
454 |
476 |
5.42e-2 |
SMART |
|
ZnF_C2H2
|
482 |
504 |
8.6e-5 |
SMART |
|
ZnF_C2H2
|
510 |
532 |
5.21e-4 |
SMART |
|
ZnF_C2H2
|
538 |
560 |
3.11e-2 |
SMART |
|
ZnF_C2H2
|
566 |
588 |
2.86e-1 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000159086
AA Change: T186S
PolyPhen 2
Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
|
| SMART Domains |
Protein: ENSMUSP00000127178
Gene: ENSMUSG00000024298
AA Change: T186S
| Domain | Start | End | E-Value | Type |
|---|
|
KRAB
|
4 |
61 |
2.18e-15 |
SMART |
|
ZnF_C2H2
|
193 |
215 |
5.9e-3 |
SMART |
|
ZnF_C2H2
|
221 |
243 |
6.32e-3 |
SMART |
|
ZnF_C2H2
|
249 |
271 |
1.47e-3 |
SMART |
|
ZnF_C2H2
|
277 |
299 |
3.63e-3 |
SMART |
|
ZnF_C2H2
|
305 |
327 |
1.79e-2 |
SMART |
|
ZnF_C2H2
|
333 |
355 |
4.79e-3 |
SMART |
|
ZnF_C2H2
|
361 |
383 |
1.69e-3 |
SMART |
|
ZnF_C2H2
|
389 |
411 |
2.79e-4 |
SMART |
|
ZnF_C2H2
|
417 |
439 |
1.23e-5 |
SMART |
|
ZnF_C2H2
|
445 |
467 |
1.2e-3 |
SMART |
|
ZnF_C2H2
|
473 |
495 |
5.42e-2 |
SMART |
|
ZnF_C2H2
|
501 |
523 |
8.6e-5 |
SMART |
|
ZnF_C2H2
|
529 |
551 |
5.21e-4 |
SMART |
|
ZnF_C2H2
|
557 |
579 |
3.11e-2 |
SMART |
|
ZnF_C2H2
|
585 |
607 |
2.86e-1 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000168337
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 18 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abca12 |
T |
A |
1: 71,306,769 (GRCm39) |
|
probably benign |
Het |
| Cep290 |
C |
T |
10: 100,336,067 (GRCm39) |
T375M |
probably damaging |
Het |
| Col1a2 |
A |
T |
6: 4,520,258 (GRCm39) |
R348* |
probably null |
Het |
| Dph6 |
A |
T |
2: 114,475,259 (GRCm39) |
Y85* |
probably null |
Het |
| Etl4 |
C |
T |
2: 20,534,898 (GRCm39) |
H118Y |
probably damaging |
Het |
| Gprc5b |
A |
G |
7: 118,583,209 (GRCm39) |
F220S |
possibly damaging |
Het |
| Larp4 |
A |
G |
15: 99,894,369 (GRCm39) |
T213A |
probably damaging |
Het |
| Mfn1 |
T |
C |
3: 32,617,515 (GRCm39) |
|
probably benign |
Het |
| Myo5a |
T |
C |
9: 75,063,531 (GRCm39) |
V579A |
probably benign |
Het |
| Nol11 |
T |
C |
11: 107,077,695 (GRCm39) |
I65M |
probably damaging |
Het |
| Or2k2 |
A |
T |
4: 58,785,047 (GRCm39) |
L225Q |
probably damaging |
Het |
| Pcdh18 |
T |
C |
3: 49,707,982 (GRCm39) |
|
probably benign |
Het |
| Prss30 |
T |
C |
17: 24,194,106 (GRCm39) |
T17A |
probably benign |
Het |
| Rab11fip3 |
A |
G |
17: 26,286,956 (GRCm39) |
L399P |
probably damaging |
Het |
| Slc44a2 |
T |
C |
9: 21,257,243 (GRCm39) |
V396A |
probably benign |
Het |
| Tns3 |
A |
G |
11: 8,442,798 (GRCm39) |
S522P |
probably damaging |
Het |
| Vmn2r94 |
A |
T |
17: 18,473,574 (GRCm39) |
V484E |
possibly damaging |
Het |
| Zmat3 |
C |
T |
3: 32,395,680 (GRCm39) |
E276K |
probably damaging |
Het |
|
| Other mutations in Zfp871 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00849:Zfp871
|
APN |
17 |
32,994,873 (GRCm39) |
missense |
probably benign |
|
|
IGL00963:Zfp871
|
APN |
17 |
32,993,726 (GRCm39) |
missense |
probably benign |
0.25 |
|
IGL02170:Zfp871
|
APN |
17 |
32,994,662 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
IGL02399:Zfp871
|
APN |
17 |
32,993,329 (GRCm39) |
missense |
probably benign |
0.18 |
|
R0304:Zfp871
|
UTSW |
17 |
32,993,408 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1215:Zfp871
|
UTSW |
17 |
32,994,946 (GRCm39) |
missense |
possibly damaging |
0.70 |
|
R1444:Zfp871
|
UTSW |
17 |
32,993,900 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R1754:Zfp871
|
UTSW |
17 |
32,994,308 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1913:Zfp871
|
UTSW |
17 |
32,994,891 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R2018:Zfp871
|
UTSW |
17 |
32,993,751 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2180:Zfp871
|
UTSW |
17 |
32,994,275 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2881:Zfp871
|
UTSW |
17 |
32,994,407 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4422:Zfp871
|
UTSW |
17 |
32,993,808 (GRCm39) |
missense |
probably benign |
0.37 |
|
R4422:Zfp871
|
UTSW |
17 |
32,993,807 (GRCm39) |
missense |
probably benign |
0.39 |
|
R4979:Zfp871
|
UTSW |
17 |
32,994,829 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5564:Zfp871
|
UTSW |
17 |
32,994,842 (GRCm39) |
missense |
possibly damaging |
0.70 |
|
R6228:Zfp871
|
UTSW |
17 |
32,994,858 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
R6232:Zfp871
|
UTSW |
17 |
32,994,494 (GRCm39) |
frame shift |
probably null |
|
|
R6233:Zfp871
|
UTSW |
17 |
32,994,494 (GRCm39) |
frame shift |
probably null |
|
|
R6234:Zfp871
|
UTSW |
17 |
32,994,494 (GRCm39) |
frame shift |
probably null |
|
|
R6474:Zfp871
|
UTSW |
17 |
32,994,647 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R7237:Zfp871
|
UTSW |
17 |
32,994,289 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7809:Zfp871
|
UTSW |
17 |
32,993,826 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8830:Zfp871
|
UTSW |
17 |
32,993,901 (GRCm39) |
missense |
probably benign |
0.03 |
|
R9219:Zfp871
|
UTSW |
17 |
32,993,914 (GRCm39) |
missense |
probably benign |
0.02 |
|
| Posted On |
2014-01-21 |
Incidental Mutation