Incidental Mutation 'IGL01688:Rras2'
ID 104020
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Rras2
Ensembl Gene ENSMUSG00000055723
Gene Name related RAS viral (r-ras) oncogene 2
Synonyms TC21, 2610016H24Rik
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.320) question?
Stock # IGL01688
Quality Score
Status
Chromosome 7
Chromosomal Location 113646017-113717016 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 113659632 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Glycine at position 44 (D44G)
Ref Sequence ENSEMBL: ENSMUSP00000147655 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000069449] [ENSMUST00000210075]
AlphaFold P62071
Predicted Effect probably damaging
Transcript: ENSMUST00000069449
AA Change: D44G

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000069752
Gene: ENSMUSG00000055723
AA Change: D44G

DomainStartEndE-ValueType
RAS 12 178 1.02e-120 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000210075
AA Change: D44G

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the R-Ras subfamily of Ras-like small GTPases. The encoded protein associates with the plasma membrane and may function as a signal transducer. This protein may play an important role in activating signal transduction pathways that control cell proliferation. Mutations in this gene are associated with the growth of certain tumors. Pseudogenes of this gene are found on chromosomes 1 and 2. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Apr 2010]
PHENOTYPE: Homozygote and heterozygote null mice are lymphopenic, resulting from diminished homeostatic proliferation and impaired T cell and B cell survival. Mice homozygous for a gene trap insertion exhibit retinal degeneration, and increased total body mass and total body fat. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 44 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700113H08Rik T C 10: 87,000,985 (GRCm39) L59P probably damaging Het
Ccin A T 4: 43,984,985 (GRCm39) E464V possibly damaging Het
Cfap58 A G 19: 47,963,006 (GRCm39) D472G probably benign Het
Col28a1 C T 6: 7,998,517 (GRCm39) E1131K probably damaging Het
Cpne2 A G 8: 95,281,381 (GRCm39) T196A possibly damaging Het
Cul4a A T 8: 13,196,571 (GRCm39) R742* probably null Het
Cyp21a1 T A 17: 35,021,194 (GRCm39) I370F probably damaging Het
Ddx51 T C 5: 110,803,513 (GRCm39) F332L probably benign Het
Gm8232 A G 14: 44,671,179 (GRCm39) D29G unknown Het
Got1 A G 19: 43,512,775 (GRCm39) probably null Het
Gpat4 A G 8: 23,671,861 (GRCm39) I58T probably benign Het
Hdac3 T A 18: 38,087,932 (GRCm39) D12V possibly damaging Het
Helb T C 10: 119,944,885 (GRCm39) H217R probably damaging Het
Hpf1 A T 8: 61,349,830 (GRCm39) I153L probably benign Het
Lgsn G A 1: 31,243,486 (GRCm39) D523N probably damaging Het
Lrrc63 A G 14: 75,322,422 (GRCm39) S561P possibly damaging Het
Myh6 G A 14: 55,201,417 (GRCm39) T94I possibly damaging Het
Mzt2 T C 16: 15,680,793 (GRCm39) probably benign Het
Ndufb5 T A 3: 32,800,613 (GRCm39) L62* probably null Het
Nek1 A T 8: 61,558,631 (GRCm39) R970* probably null Het
Nepro T C 16: 44,556,369 (GRCm39) L509P probably damaging Het
Pank1 T A 19: 34,818,252 (GRCm39) I96F probably damaging Het
Parp11 C A 6: 127,448,569 (GRCm39) T62K probably benign Het
Pla2g2e T A 4: 138,606,781 (GRCm39) probably benign Het
Plekha5 T A 6: 140,515,115 (GRCm39) Y207N probably damaging Het
Pomt2 T A 12: 87,194,294 (GRCm39) I37F probably benign Het
Prl6a1 T A 13: 27,501,969 (GRCm39) V117E probably damaging Het
Prmt3 T A 7: 49,498,480 (GRCm39) probably null Het
Rcor3 T A 1: 191,807,900 (GRCm39) E20V probably damaging Het
Rere A G 4: 150,702,893 (GRCm39) D1449G probably damaging Het
Ric1 T C 19: 29,555,014 (GRCm39) V376A probably benign Het
Rims1 G A 1: 22,467,764 (GRCm39) T873I probably benign Het
Sbk2 C T 7: 4,960,716 (GRCm39) probably benign Het
Slit1 A G 19: 41,717,545 (GRCm39) I73T probably damaging Het
Spice1 T A 16: 44,205,073 (GRCm39) M793K probably benign Het
Suco T C 1: 161,691,480 (GRCm39) probably null Het
Tarbp1 A T 8: 127,174,290 (GRCm39) W839R probably damaging Het
Trpc4 T A 3: 54,173,495 (GRCm39) probably benign Het
Tubgcp5 T C 7: 55,464,766 (GRCm39) V549A possibly damaging Het
Ubap2 T A 4: 41,226,308 (GRCm39) T182S probably benign Het
Wrn A C 8: 33,800,730 (GRCm39) probably benign Het
Zc3h15 A G 2: 83,492,536 (GRCm39) Y337C probably damaging Het
Zfp292 T A 4: 34,807,855 (GRCm39) I1730F possibly damaging Het
Zfp609 A G 9: 65,611,307 (GRCm39) V552A probably benign Het
Other mutations in Rras2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02028:Rras2 APN 7 113,659,597 (GRCm39) missense probably benign 0.01
IGL02108:Rras2 APN 7 113,659,623 (GRCm39) missense probably damaging 1.00
R0017:Rras2 UTSW 7 113,647,490 (GRCm39) splice site probably benign
R0017:Rras2 UTSW 7 113,647,490 (GRCm39) splice site probably benign
R4718:Rras2 UTSW 7 113,649,584 (GRCm39) missense probably benign 0.00
R5371:Rras2 UTSW 7 113,649,572 (GRCm39) missense probably damaging 1.00
R5534:Rras2 UTSW 7 113,649,650 (GRCm39) missense possibly damaging 0.47
R7871:Rras2 UTSW 7 113,716,783 (GRCm39) start gained probably benign
R7982:Rras2 UTSW 7 113,658,186 (GRCm39) missense probably damaging 1.00
R9731:Rras2 UTSW 7 113,659,593 (GRCm39) missense probably damaging 1.00
R9748:Rras2 UTSW 7 113,716,629 (GRCm39) critical splice donor site probably null
Posted On 2014-01-21