Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01693:Swt1'

104189

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Swt1

Ensembl Gene

ENSMUSG00000052748

Gene Name

SWT1 RNA endoribonuclease homolog (S. cerevisiae)

Synonyms

1200016B10Rik

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.150) question?

Stock #

IGL01693

Quality Score

Status

Chromosome

Chromosomal Location

151243450-151304206 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 151297855 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Threonine at position 24 (I24T)

Ref Sequence

ENSEMBL: ENSMUSP00000107514 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000064771] [ENSMUST00000111883]

AlphaFold

Q9DBQ9

Predicted Effect

probably benign
Transcript: ENSMUST00000064771
AA Change: I24T

PolyPhen 2 Score 0.024 (Sensitivity: 0.95; Specificity: 0.81)

SMART Domains

Protein: ENSMUSP00000067516
Gene: ENSMUSG00000052748
AA Change: I24T

Domain	Start	End	E-Value	Type
low complexity region	186	206	N/A	INTRINSIC
low complexity region	231	242	N/A	INTRINSIC
low complexity region	258	269	N/A	INTRINSIC
PINc	395	522	1.94e-9	SMART
low complexity region	783	793	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000111883
AA Change: I24T

PolyPhen 2 Score 0.024 (Sensitivity: 0.95; Specificity: 0.81)

SMART Domains

Protein: ENSMUSP00000107514
Gene: ENSMUSG00000052748
AA Change: I24T

Domain	Start	End	E-Value	Type
low complexity region	186	206	N/A	INTRINSIC
low complexity region	231	242	N/A	INTRINSIC
low complexity region	258	269	N/A	INTRINSIC
PINc	395	522	1.94e-9	SMART

Predicted Effect

unknown
Transcript: ENSMUST00000129939
AA Change: I22T

SMART Domains

Protein: ENSMUSP00000120483
Gene: ENSMUSG00000052748
AA Change: I22T

Domain	Start	End	E-Value	Type
PINc	146	245	6.78e-1	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000131312

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000185247

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 28 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Akr1b8	T	A	6: 34,340,271 (GRCm39)	M145K	possibly damaging	Het
Arhgap39	T	C	15: 76,610,167 (GRCm39)	D943G	probably null	Het
Arhgap42	A	T	9: 9,006,507 (GRCm39)	W630R	probably damaging	Het
Bbs5	T	A	2: 69,493,424 (GRCm39)	S225T	probably benign	Het
Cacna1f	A	T	X: 7,491,606 (GRCm39)	N1159Y	probably damaging	Het
Catsperg1	A	G	7: 28,884,523 (GRCm39)		probably benign	Het
Cemip2	A	C	19: 21,779,251 (GRCm39)	I354L	probably benign	Het
Cep15	T	C	14: 12,287,380 (GRCm38)	L55P	probably damaging	Het
Cep97	A	T	16: 55,750,957 (GRCm39)	W20R	probably damaging	Het
Cmtm8	G	A	9: 114,618,773 (GRCm39)	T160M	probably damaging	Het
Csf2ra	A	G	19: 61,214,434 (GRCm39)	S244P	possibly damaging	Het
Dnah7b	C	T	1: 46,397,307 (GRCm39)	P3913S	probably benign	Het
Dnai4	T	C	4: 102,944,527 (GRCm39)		probably null	Het
Ezh1	C	T	11: 101,106,084 (GRCm39)	M100I	probably benign	Het
Gadl1	C	A	9: 115,778,653 (GRCm39)	P189Q	probably damaging	Het
Gcnt2	G	A	13: 41,041,549 (GRCm39)	S236N	probably benign	Het
H1f7	A	C	15: 98,154,262 (GRCm39)	Y296D	unknown	Het
Hmcn1	T	A	1: 150,459,031 (GRCm39)	D5191V	probably damaging	Het
Mycbp2	A	T	14: 103,365,415 (GRCm39)	D4194E	probably damaging	Het
Ncf2	C	A	1: 152,700,074 (GRCm39)	T203K	probably benign	Het
Or5a1	C	A	19: 12,097,921 (GRCm39)	V40L	probably benign	Het
Pate8	G	A	9: 36,492,662 (GRCm39)	T81I	probably benign	Het
Phf8	T	A	X: 150,333,871 (GRCm39)	V113E	probably damaging	Het
Pkm	G	T	9: 59,577,805 (GRCm39)	K207N	probably damaging	Het
Slco1a6	G	T	6: 142,078,935 (GRCm39)	S120*	probably null	Het
Sox10	C	T	15: 79,040,473 (GRCm39)	V195M	possibly damaging	Het
Thada	T	C	17: 84,754,072 (GRCm39)	T300A	probably benign	Het
Vmn2r17	T	C	5: 109,600,384 (GRCm39)	Y561H	probably damaging	Het

Other mutations in Swt1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01109:Swt1	APN	1	151,286,890 (GRCm39)	missense	probably damaging	0.99
IGL01622:Swt1	APN	1	151,286,760 (GRCm39)	missense	probably benign	0.01
IGL01623:Swt1	APN	1	151,286,760 (GRCm39)	missense	probably benign	0.01
IGL01672:Swt1	APN	1	151,270,359 (GRCm39)	critical splice donor site	probably null
IGL02203:Swt1	APN	1	151,246,377 (GRCm39)	missense	probably benign	0.01
IGL03223:Swt1	APN	1	151,255,170 (GRCm39)	missense	possibly damaging	0.80
R0124:Swt1	UTSW	1	151,267,280 (GRCm39)	missense	probably damaging	1.00
R0496:Swt1	UTSW	1	151,287,021 (GRCm39)	missense	probably benign
R1037:Swt1	UTSW	1	151,246,320 (GRCm39)	splice site	probably benign
R1171:Swt1	UTSW	1	151,281,272 (GRCm39)	missense	probably damaging	1.00
R1270:Swt1	UTSW	1	151,260,142 (GRCm39)	missense	probably benign	0.00
R1883:Swt1	UTSW	1	151,299,284 (GRCm39)	nonsense	probably null
R2051:Swt1	UTSW	1	151,248,081 (GRCm39)	missense	probably damaging	1.00
R2110:Swt1	UTSW	1	151,279,636 (GRCm39)	missense	probably damaging	0.97
R2185:Swt1	UTSW	1	151,260,219 (GRCm39)	missense	probably damaging	1.00
R3688:Swt1	UTSW	1	151,267,240 (GRCm39)	missense	probably damaging	0.99
R3785:Swt1	UTSW	1	151,255,155 (GRCm39)	missense	probably benign	0.03
R4074:Swt1	UTSW	1	151,270,520 (GRCm39)	missense	probably benign
R4157:Swt1	UTSW	1	151,278,795 (GRCm39)	missense	probably damaging	1.00
R4660:Swt1	UTSW	1	151,283,348 (GRCm39)	missense	probably benign	0.18
R4761:Swt1	UTSW	1	151,276,853 (GRCm39)	missense	probably benign	0.43
R4972:Swt1	UTSW	1	151,299,293 (GRCm39)	missense	probably benign	0.22
R5141:Swt1	UTSW	1	151,287,145 (GRCm39)	missense	probably benign	0.04
R5227:Swt1	UTSW	1	151,278,727 (GRCm39)	nonsense	probably null
R5400:Swt1	UTSW	1	151,288,585 (GRCm39)	missense	probably benign	0.00
R5580:Swt1	UTSW	1	151,260,206 (GRCm39)	missense	probably benign	0.00
R5912:Swt1	UTSW	1	151,287,160 (GRCm39)	missense	probably damaging	1.00
R5945:Swt1	UTSW	1	151,286,921 (GRCm39)	missense	probably benign	0.01
R5973:Swt1	UTSW	1	151,278,700 (GRCm39)	splice site	probably null
R5979:Swt1	UTSW	1	151,283,339 (GRCm39)	missense	possibly damaging	0.94
R6242:Swt1	UTSW	1	151,283,365 (GRCm39)	missense	probably benign	0.41
R6283:Swt1	UTSW	1	151,260,084 (GRCm39)	missense	possibly damaging	0.78
R6951:Swt1	UTSW	1	151,273,019 (GRCm39)	missense	possibly damaging	0.88
R7009:Swt1	UTSW	1	151,246,381 (GRCm39)	missense	possibly damaging	0.94
R7165:Swt1	UTSW	1	151,264,428 (GRCm39)	missense	probably damaging	1.00
R7214:Swt1	UTSW	1	151,270,364 (GRCm39)	missense	possibly damaging	0.63
R7403:Swt1	UTSW	1	151,264,444 (GRCm39)	missense	probably benign	0.01
R7439:Swt1	UTSW	1	151,286,815 (GRCm39)	missense	probably benign	0.04
R7441:Swt1	UTSW	1	151,286,815 (GRCm39)	missense	probably benign	0.04
R7571:Swt1	UTSW	1	151,270,470 (GRCm39)	missense	probably benign	0.00
R8028:Swt1	UTSW	1	151,260,248 (GRCm39)	missense	probably benign	0.26
R8225:Swt1	UTSW	1	151,297,859 (GRCm39)	missense	possibly damaging	0.96
R9075:Swt1	UTSW	1	151,246,245 (GRCm39)	intron	probably benign
R9100:Swt1	UTSW	1	151,299,256 (GRCm39)	critical splice donor site	probably null
R9135:Swt1	UTSW	1	151,244,239 (GRCm39)	missense	possibly damaging	0.61
R9291:Swt1	UTSW	1	151,286,694 (GRCm39)	missense	probably damaging	0.96
R9292:Swt1	UTSW	1	151,278,787 (GRCm39)	missense	probably benign	0.00
R9368:Swt1	UTSW	1	151,286,767 (GRCm39)	missense	possibly damaging	0.90
X0062:Swt1	UTSW	1	151,287,190 (GRCm39)	missense	probably benign	0.43
Z1176:Swt1	UTSW	1	151,264,436 (GRCm39)	missense	probably damaging	0.98

Posted On

2014-01-21