Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01693:Pate8'

104191

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Pate8

Ensembl Gene

ENSMUSG00000091248

Gene Name

prostate and testis expressed 8

Synonyms

Gm17689

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.053) question?

Stock #

IGL01693

Quality Score

Status

Chromosome

Chromosomal Location

36492574-36493931 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

G to A at 36492662 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Threonine to Isoleucine at position 81 (T81I)

Ref Sequence

ENSEMBL: ENSMUSP00000126891 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000170030]

AlphaFold

B3GLJ4

Predicted Effect

probably benign
Transcript: ENSMUST00000170030
AA Change: T81I

PolyPhen 2 Score 0.306 (Sensitivity: 0.90; Specificity: 0.89)

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 28 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Akr1b8	T	A	6: 34,340,271 (GRCm39)	M145K	possibly damaging	Het
Arhgap39	T	C	15: 76,610,167 (GRCm39)	D943G	probably null	Het
Arhgap42	A	T	9: 9,006,507 (GRCm39)	W630R	probably damaging	Het
Bbs5	T	A	2: 69,493,424 (GRCm39)	S225T	probably benign	Het
Cacna1f	A	T	X: 7,491,606 (GRCm39)	N1159Y	probably damaging	Het
Catsperg1	A	G	7: 28,884,523 (GRCm39)		probably benign	Het
Cemip2	A	C	19: 21,779,251 (GRCm39)	I354L	probably benign	Het
Cep15	T	C	14: 12,287,380 (GRCm38)	L55P	probably damaging	Het
Cep97	A	T	16: 55,750,957 (GRCm39)	W20R	probably damaging	Het
Cmtm8	G	A	9: 114,618,773 (GRCm39)	T160M	probably damaging	Het
Csf2ra	A	G	19: 61,214,434 (GRCm39)	S244P	possibly damaging	Het
Dnah7b	C	T	1: 46,397,307 (GRCm39)	P3913S	probably benign	Het
Dnai4	T	C	4: 102,944,527 (GRCm39)		probably null	Het
Ezh1	C	T	11: 101,106,084 (GRCm39)	M100I	probably benign	Het
Gadl1	C	A	9: 115,778,653 (GRCm39)	P189Q	probably damaging	Het
Gcnt2	G	A	13: 41,041,549 (GRCm39)	S236N	probably benign	Het
H1f7	A	C	15: 98,154,262 (GRCm39)	Y296D	unknown	Het
Hmcn1	T	A	1: 150,459,031 (GRCm39)	D5191V	probably damaging	Het
Mycbp2	A	T	14: 103,365,415 (GRCm39)	D4194E	probably damaging	Het
Ncf2	C	A	1: 152,700,074 (GRCm39)	T203K	probably benign	Het
Or5a1	C	A	19: 12,097,921 (GRCm39)	V40L	probably benign	Het
Phf8	T	A	X: 150,333,871 (GRCm39)	V113E	probably damaging	Het
Pkm	G	T	9: 59,577,805 (GRCm39)	K207N	probably damaging	Het
Slco1a6	G	T	6: 142,078,935 (GRCm39)	S120*	probably null	Het
Sox10	C	T	15: 79,040,473 (GRCm39)	V195M	possibly damaging	Het
Swt1	A	G	1: 151,297,855 (GRCm39)	I24T	probably benign	Het
Thada	T	C	17: 84,754,072 (GRCm39)	T300A	probably benign	Het
Vmn2r17	T	C	5: 109,600,384 (GRCm39)	Y561H	probably damaging	Het

Other mutations in Pate8

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01455:Pate8	APN	9	36,492,659 (GRCm39)	missense	probably benign	0.00
IGL02268:Pate8	APN	9	36,493,166 (GRCm39)	missense	possibly damaging	0.71
IGL03191:Pate8	APN	9	36,492,698 (GRCm39)	missense	probably benign	0.00
PIT4354001:Pate8	UTSW	9	36,492,597 (GRCm39)	missense	possibly damaging	0.71
R0401:Pate8	UTSW	9	36,493,924 (GRCm39)	missense	unknown
R0743:Pate8	UTSW	9	36,492,597 (GRCm39)	missense	probably benign	0.03
R1483:Pate8	UTSW	9	36,492,620 (GRCm39)	missense	probably benign	0.00
R1701:Pate8	UTSW	9	36,493,114 (GRCm39)	critical splice donor site	probably benign
R2258:Pate8	UTSW	9	36,493,161 (GRCm39)	missense	probably benign	0.03
R3764:Pate8	UTSW	9	36,493,114 (GRCm39)	critical splice donor site	probably null
R5143:Pate8	UTSW	9	36,493,200 (GRCm39)	missense	probably benign	0.31
R6783:Pate8	UTSW	9	36,492,631 (GRCm39)	splice site	probably null
R7013:Pate8	UTSW	9	36,493,854 (GRCm39)	missense	unknown
R7014:Pate8	UTSW	9	36,493,854 (GRCm39)	missense	unknown

Posted On

2014-01-21