Incidental Mutation 'IGL01694:Opalin'
ID104223
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Opalin
Ensembl Gene ENSMUSG00000050121
Gene Nameoligodendrocytic myelin paranodal and inner loop protein
SynonymsTmem10, Tmp10
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.064) question?
Stock #IGL01694
Quality Score
Status
Chromosome19
Chromosomal Location41062474-41077113 bp(-) (GRCm38)
Type of Mutationunclassified
DNA Base Change (assembly) A to G at 41063800 bp
ZygosityHeterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000107819 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000051806] [ENSMUST00000087176] [ENSMUST00000112200]
Predicted Effect probably benign
Transcript: ENSMUST00000051806
SMART Domains Protein: ENSMUSP00000062078
Gene: ENSMUSG00000025014

DomainStartEndE-ValueType
BRCT 29 114 3.05e-9 SMART
POLXc 163 529 5.68e-196 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000087176
SMART Domains Protein: ENSMUSP00000084422
Gene: ENSMUSG00000050121

DomainStartEndE-ValueType
low complexity region 8 21 N/A INTRINSIC
transmembrane domain 31 53 N/A INTRINSIC
low complexity region 122 136 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000112200
SMART Domains Protein: ENSMUSP00000107819
Gene: ENSMUSG00000025014

DomainStartEndE-ValueType
BRCT 29 114 3.05e-9 SMART
POLXc 163 509 1.19e-198 SMART
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 32 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930474N05Rik A G 14: 36,096,702 *219W probably null Het
Abi1 G A 2: 22,960,713 T238M probably damaging Het
Agbl2 C T 2: 90,801,074 L259F probably damaging Het
Cacna1g T A 11: 94,429,112 I1413F probably damaging Het
Ddx21 T A 10: 62,598,651 K110* probably null Het
Dnm1l A T 16: 16,316,651 I463N probably benign Het
Dst C A 1: 34,188,160 H1286Q probably benign Het
Elmo2 A T 2: 165,314,773 N67K probably benign Het
Eps8l3 G A 3: 107,892,308 C578Y probably damaging Het
Fam83b T A 9: 76,490,990 I944F probably benign Het
Itga10 A T 3: 96,652,517 D496V probably damaging Het
Lama2 T G 10: 27,006,742 K2608N possibly damaging Het
Lap3 T A 5: 45,498,595 probably null Het
Madd T C 2: 91,157,975 probably benign Het
Mdh1b T A 1: 63,711,106 probably benign Het
Ncapg2 G A 12: 116,407,230 probably benign Het
Olfr1509 A G 14: 52,450,584 N57S probably benign Het
Plxna3 T A X: 74,338,508 D1291E probably damaging Het
Prss40 T A 1: 34,556,097 I101F probably benign Het
Rpl5 T C 5: 107,907,240 Y253H probably benign Het
Sephs2 A G 7: 127,273,087 I278T probably benign Het
Slc25a34 G A 4: 141,622,253 A197V probably benign Het
Slco6d1 C T 1: 98,499,845 R634W probably damaging Het
Smarca4 C A 9: 21,665,870 A871D probably damaging Het
Speer2 C T 16: 69,858,112 S155N probably damaging Het
Speer2 T A 16: 69,858,113 S155C probably damaging Het
Spink12 T A 18: 44,107,760 V71E probably damaging Het
Tecta T C 9: 42,367,179 D1011G possibly damaging Het
Tmtc4 G A 14: 122,973,212 T78I possibly damaging Het
Tub T C 7: 109,021,036 probably benign Het
Vps13c T A 9: 67,895,349 V644D probably damaging Het
Zfp7 C T 15: 76,890,795 Q346* probably null Het
Other mutations in Opalin
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02025:Opalin APN 19 41072235 splice site probably benign
IGL02282:Opalin APN 19 41066504 missense probably benign 0.40
IGL02878:Opalin APN 19 41067669 missense probably benign 0.19
BB002:Opalin UTSW 19 41063803 makesense probably null
BB012:Opalin UTSW 19 41063803 makesense probably null
R0881:Opalin UTSW 19 41063981 critical splice acceptor site probably null
R1781:Opalin UTSW 19 41067631 splice site probably null
R4579:Opalin UTSW 19 41067757 missense probably damaging 0.98
R5455:Opalin UTSW 19 41069953 missense probably benign 0.20
R5470:Opalin UTSW 19 41066531 missense probably benign 0.34
R7161:Opalin UTSW 19 41069935 missense possibly damaging 0.50
R7925:Opalin UTSW 19 41063803 makesense probably null
Posted On2014-01-21