Mutagenetix > Incidental Mutations

Incidental Mutation 'IGL00870:Dytn'

10427

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Dytn

Ensembl Gene

ENSMUSG00000069085

Gene Name

dystrotelin

Synonyms

LOC241073

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.055) question?

Stock #

IGL00870

Quality Score

Status

Chromosome

Chromosomal Location

63622851-63686927 bp(-) (GRCm38)

Type of Mutation

splice site

DNA Base Change (assembly)

T to C at 63677113 bp

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000087787 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000090313]

Predicted Effect

probably benign
Transcript: ENSMUST00000090313

SMART Domains

Protein: ENSMUSP00000087787
Gene: ENSMUSG00000069085

Domain	Start	End	E-Value	Type
Pfam:EF-hand_2	5	118	8.2e-14	PFAM
Pfam:EF-hand_3	123	217	7.2e-20	PFAM
ZnF_ZZ	222	267	7.34e-13	SMART
coiled coil region	382	411	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000126954

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 31 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Ahnak	T	A	19: 9,013,698	D4115E	probably damaging	Het
Asb5	T	C	8: 54,583,660		probably null	Het
Cpeb3	A	T	19: 37,054,295	I569N	probably damaging	Het
Cpsf7	T	C	19: 10,539,650		probably null	Het
Dlat	A	G	9: 50,650,869	L285P	probably damaging	Het
Ears2	A	T	7: 122,055,676	L123Q	probably damaging	Het
Gad2	T	C	2: 22,629,971	V212A	probably benign	Het
Gon4l	T	C	3: 88,857,185	Y358H	probably damaging	Het
Gys1	T	C	7: 45,448,013		probably null	Het
Hnrnpm	C	A	17: 33,649,902	R517L	probably damaging	Het
Krtap20-2	G	A	16: 89,205,987	G25D	unknown	Het
Lrif1	T	C	3: 106,734,641		probably null	Het
Naip2	A	G	13: 100,152,060		probably benign	Het
Olfr884	A	T	9: 38,047,740	I173F	probably damaging	Het
Oxct1	T	A	15: 4,101,818	L396Q	probably damaging	Het
Pclo	A	T	5: 14,539,983	R766W	unknown	Het
Pkhd1	T	A	1: 20,571,390	I275F	probably damaging	Het
Rxfp3	A	G	15: 11,036,215	F357S	probably damaging	Het
Rxfp3	A	G	15: 11,036,305	V327A	probably damaging	Het
Serpinb2	A	G	1: 107,523,070	I181V	probably damaging	Het
Smad5	A	G	13: 56,723,667	D25G	probably benign	Het
Strada	A	G	11: 106,171,257	L82P	probably damaging	Het
Tek	T	A	4: 94,873,081	Y1079*	probably null	Het
Tenm3	T	C	8: 48,417,132	T209A	probably benign	Het
Tnks1bp1	C	T	2: 85,062,236	Q836*	probably null	Het
Toporsl	T	C	4: 52,610,172	S22P	probably benign	Het
Ttc17	T	C	2: 94,371,733		probably null	Het
Ttc39a	A	G	4: 109,442,345		probably benign	Het
Vangl1	T	C	3: 102,189,440	D60G	probably damaging	Het
Vmn1r13	A	T	6: 57,210,113	M86L	probably benign	Het
Vmn1r220	C	T	13: 23,184,477	M16I	probably null	Het

Other mutations in Dytn

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00502:Dytn	APN	1	63678840	missense	probably benign	0.34
IGL02110:Dytn	APN	1	63647473	missense	possibly damaging	0.86
IGL02124:Dytn	APN	1	63641092	missense	probably damaging	1.00
IGL02211:Dytn	APN	1	63674930	missense	possibly damaging	0.61
IGL02712:Dytn	APN	1	63664422	missense	probably benign	0.00
IGL02832:Dytn	APN	1	63643373	missense	probably benign	0.45
IGL03036:Dytn	APN	1	63641122	missense	probably damaging	0.97
H8562:Dytn	UTSW	1	63674912	missense	possibly damaging	0.88
R0306:Dytn	UTSW	1	63685113	missense	possibly damaging	0.89
R0441:Dytn	UTSW	1	63678774	splice site	probably benign
R1453:Dytn	UTSW	1	63633873	missense	probably damaging	0.99
R1655:Dytn	UTSW	1	63661198	missense	probably damaging	1.00
R1892:Dytn	UTSW	1	63677261	missense	probably benign	0.04
R3030:Dytn	UTSW	1	63633519	missense	probably benign	0.04
R4062:Dytn	UTSW	1	63647447	missense	probably benign	0.05
R4640:Dytn	UTSW	1	63643348	missense	possibly damaging	0.52
R4804:Dytn	UTSW	1	63643366	missense	probably benign	0.08
R4931:Dytn	UTSW	1	63633678	missense	probably benign	0.26
R5015:Dytn	UTSW	1	63633695	missense	probably benign	0.00
R5054:Dytn	UTSW	1	63661159	missense	possibly damaging	0.64
R5120:Dytn	UTSW	1	63623043	missense	probably benign
R5888:Dytn	UTSW	1	63677237	missense	possibly damaging	0.91
R6243:Dytn	UTSW	1	63647521	missense	possibly damaging	0.76
R6400:Dytn	UTSW	1	63641176	nonsense	probably null
R7595:Dytn	UTSW	1	63659002	missense	probably damaging	0.99
R7705:Dytn	UTSW	1	63678789	missense	probably damaging	1.00
R8445:Dytn	UTSW	1	63647514	missense	probably benign	0.04
Z1177:Dytn	UTSW	1	63633454	nonsense	probably null

Posted On

2012-12-06