Incidental Mutation 'IGL01697:Or13a17'
ID 104297
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Or13a17
Ensembl Gene ENSMUSG00000066122
Gene Name olfactory receptor family 13 subfamily A member 17
Synonyms IB6, Olfr45, MOR253-2, GA_x6K02T2PBJ9-42837030-42837962
Accession Numbers
Essential gene? Probably non essential (E-score: 0.068) question?
Stock # IGL01697
Quality Score
Chromosome 7
Chromosomal Location 140270797-140271832 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 140271565 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Alanine at position 249 (V249A)
Ref Sequence ENSEMBL: ENSMUSP00000149309 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000084454] [ENSMUST00000210241] [ENSMUST00000214637]
AlphaFold Q8VGM1
Predicted Effect possibly damaging
Transcript: ENSMUST00000084454
AA Change: V249A

PolyPhen 2 Score 0.607 (Sensitivity: 0.87; Specificity: 0.91)
SMART Domains Protein: ENSMUSP00000081492
Gene: ENSMUSG00000066122
AA Change: V249A

Pfam:7tm_4 32 308 2.8e-50 PFAM
Pfam:7TM_GPCR_Srsx 36 176 1.2e-7 PFAM
Pfam:7tm_1 42 291 3.7e-21 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000210241
AA Change: V249A
Predicted Effect possibly damaging
Transcript: ENSMUST00000214637
AA Change: V249A

PolyPhen 2 Score 0.607 (Sensitivity: 0.87; Specificity: 0.91)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 30 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
9430015G10Rik T A 4: 156,203,613 (GRCm39) probably benign Het
Arid2 A C 15: 96,259,453 (GRCm39) probably null Het
Cadm1 C A 9: 47,761,622 (GRCm39) D435E probably damaging Het
Dagla A G 19: 10,248,562 (GRCm39) F33L probably benign Het
Edrf1 A G 7: 133,245,459 (GRCm39) H199R probably benign Het
F5 T A 1: 164,021,621 (GRCm39) N1365K probably benign Het
Gipc2 T G 3: 151,843,245 (GRCm39) I131L probably benign Het
Gpc1 C T 1: 92,786,132 (GRCm39) S507F possibly damaging Het
Grid1 A G 14: 35,031,214 (GRCm39) D269G probably benign Het
Ighv12-3 A T 12: 114,330,573 (GRCm39) M1K probably null Het
Kif5b T C 18: 6,226,871 (GRCm39) H129R possibly damaging Het
Lipo3 A T 19: 33,536,965 (GRCm39) C252S probably damaging Het
Mast4 A C 13: 102,904,401 (GRCm39) N645K probably damaging Het
Megf9 T A 4: 70,351,709 (GRCm39) T471S possibly damaging Het
Mmrn1 A G 6: 60,953,477 (GRCm39) D586G possibly damaging Het
Ninl A T 2: 150,781,867 (GRCm39) L1206Q probably damaging Het
Oog2 T A 4: 143,921,754 (GRCm39) N221K possibly damaging Het
Or5b96 T A 19: 12,867,831 (GRCm39) T37S probably benign Het
Or6c8b C A 10: 128,882,371 (GRCm39) C187F probably damaging Het
Pik3ap1 G A 19: 41,313,018 (GRCm39) A365V probably damaging Het
Ppwd1 T C 13: 104,356,972 (GRCm39) E181G probably benign Het
Scaf11 A C 15: 96,321,504 (GRCm39) probably benign Het
Skic3 C T 13: 76,276,852 (GRCm39) L479F probably benign Het
Skint7 T A 4: 111,837,654 (GRCm39) probably benign Het
Sox14 T C 9: 99,757,716 (GRCm39) I8V probably benign Het
Spata31f3 T A 4: 42,874,163 (GRCm39) M2L probably benign Het
Stim1 A T 7: 102,075,176 (GRCm39) probably benign Het
Ttll3 T C 6: 113,376,690 (GRCm39) S357P probably benign Het
Vmn1r178 T A 7: 23,593,114 (GRCm39) I54N probably damaging Het
Zdhhc2 T C 8: 40,920,460 (GRCm39) probably benign Het
Other mutations in Or13a17
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00094:Or13a17 APN 7 140,271,349 (GRCm39) missense probably damaging 1.00
IGL01434:Or13a17 APN 7 140,271,531 (GRCm39) missense probably damaging 1.00
IGL02167:Or13a17 APN 7 140,271,664 (GRCm39) missense probably damaging 0.98
IGL02388:Or13a17 APN 7 140,271,024 (GRCm39) missense probably benign 0.00
IGL03054:Or13a17 UTSW 7 140,271,623 (GRCm39) missense probably benign 0.10
R0107:Or13a17 UTSW 7 140,271,258 (GRCm39) missense probably benign
R0403:Or13a17 UTSW 7 140,271,222 (GRCm39) missense possibly damaging 0.80
R1344:Or13a17 UTSW 7 140,271,712 (GRCm39) missense probably damaging 0.98
R1859:Or13a17 UTSW 7 140,271,571 (GRCm39) missense possibly damaging 0.80
R2871:Or13a17 UTSW 7 140,271,198 (GRCm39) missense possibly damaging 0.95
R2871:Or13a17 UTSW 7 140,271,198 (GRCm39) missense possibly damaging 0.95
R3611:Or13a17 UTSW 7 140,271,013 (GRCm39) missense probably benign 0.01
R3915:Or13a17 UTSW 7 140,270,888 (GRCm39) missense probably benign
R4551:Or13a17 UTSW 7 140,271,655 (GRCm39) missense probably damaging 1.00
R4552:Or13a17 UTSW 7 140,271,655 (GRCm39) missense probably damaging 1.00
R4627:Or13a17 UTSW 7 140,271,291 (GRCm39) missense probably benign 0.00
R4628:Or13a17 UTSW 7 140,271,291 (GRCm39) missense probably benign 0.00
R4629:Or13a17 UTSW 7 140,271,291 (GRCm39) missense probably benign 0.00
R4990:Or13a17 UTSW 7 140,271,360 (GRCm39) missense probably damaging 0.99
R5503:Or13a17 UTSW 7 140,271,309 (GRCm39) missense probably benign 0.01
R7861:Or13a17 UTSW 7 140,271,484 (GRCm39) missense probably damaging 1.00
R8077:Or13a17 UTSW 7 140,271,046 (GRCm39) missense probably benign 0.16
R8268:Or13a17 UTSW 7 140,271,430 (GRCm39) missense probably damaging 1.00
R8532:Or13a17 UTSW 7 140,271,712 (GRCm39) missense probably damaging 0.98
R8978:Or13a17 UTSW 7 140,271,642 (GRCm39) missense probably benign
Posted On 2014-01-21