Incidental Mutation 'IGL01697:Olfr765'
ID104299
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr765
Ensembl Gene ENSMUSG00000056853
Gene Nameolfactory receptor 765
SynonymsGA_x6K02T2PULF-10732607-10731678, MOR115-4
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.083) question?
Stock #IGL01697
Quality Score
Status
Chromosome10
Chromosomal Location129044817-129049998 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) C to A at 129046502 bp
ZygosityHeterozygous
Amino Acid Change Cysteine to Phenylalanine at position 187 (C187F)
Ref Sequence ENSEMBL: ENSMUSP00000150725 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000071559] [ENSMUST00000216460]
Predicted Effect probably damaging
Transcript: ENSMUST00000071559
AA Change: C187F

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000071490
Gene: ENSMUSG00000056853
AA Change: C187F

DomainStartEndE-ValueType
Pfam:7tm_4 29 306 1.4e-49 PFAM
Pfam:7tm_1 39 288 7.8e-23 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000216460
AA Change: C187F

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 30 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
9430015G10Rik T A 4: 156,119,156 probably benign Het
Arid2 A C 15: 96,361,572 probably null Het
Cadm1 C A 9: 47,850,324 D435E probably damaging Het
Dagla A G 19: 10,271,198 F33L probably benign Het
Edrf1 A G 7: 133,643,730 H199R probably benign Het
F5 T A 1: 164,194,052 N1365K probably benign Het
Fam205c T A 4: 42,874,163 M2L probably benign Het
Gipc2 T G 3: 152,137,608 I131L probably benign Het
Gpc1 C T 1: 92,858,410 S507F possibly damaging Het
Grid1 A G 14: 35,309,257 D269G probably benign Het
Ighv12-3 A T 12: 114,366,953 M1K probably null Het
Kif5b T C 18: 6,226,871 H129R possibly damaging Het
Lipo3 A T 19: 33,559,565 C252S probably damaging Het
Mast4 A C 13: 102,767,893 N645K probably damaging Het
Megf9 T A 4: 70,433,472 T471S possibly damaging Het
Mmrn1 A G 6: 60,976,493 D586G possibly damaging Het
Ninl A T 2: 150,939,947 L1206Q probably damaging Het
Olfr1446 T A 19: 12,890,467 T37S probably benign Het
Olfr45 T C 7: 140,691,652 V249A possibly damaging Het
Oog2 T A 4: 144,195,184 N221K possibly damaging Het
Pik3ap1 G A 19: 41,324,579 A365V probably damaging Het
Ppwd1 T C 13: 104,220,464 E181G probably benign Het
Scaf11 A C 15: 96,423,623 probably benign Het
Skint7 T A 4: 111,980,457 probably benign Het
Sox14 T C 9: 99,875,663 I8V probably benign Het
Stim1 A T 7: 102,425,969 probably benign Het
Ttc37 C T 13: 76,128,733 L479F probably benign Het
Ttll3 T C 6: 113,399,729 S357P probably benign Het
Vmn1r178 T A 7: 23,893,689 I54N probably damaging Het
Zdhhc2 T C 8: 40,467,419 probably benign Het
Other mutations in Olfr765
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01335:Olfr765 APN 10 129046511 missense probably benign 0.06
R0313:Olfr765 UTSW 10 129046826 missense possibly damaging 0.61
R0346:Olfr765 UTSW 10 129046473 missense possibly damaging 0.90
R1114:Olfr765 UTSW 10 129046842 missense possibly damaging 0.95
R1157:Olfr765 UTSW 10 129046158 missense probably benign 0.35
R2351:Olfr765 UTSW 10 129046928 missense probably benign
R5119:Olfr765 UTSW 10 129046842 missense possibly damaging 0.95
R5531:Olfr765 UTSW 10 129046564 missense probably damaging 1.00
R5540:Olfr765 UTSW 10 129046495 missense probably damaging 0.96
R5756:Olfr765 UTSW 10 129046226 missense probably benign 0.04
R6011:Olfr765 UTSW 10 129046639 missense probably benign
R7021:Olfr765 UTSW 10 129047030 missense probably damaging 0.99
R7257:Olfr765 UTSW 10 129046455 missense probably benign 0.13
R7330:Olfr765 UTSW 10 129046464 missense probably damaging 0.97
Posted On2014-01-21