Incidental Mutation 'IGL01697:Megf9'
ID104317
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Megf9
Ensembl Gene ENSMUSG00000039270
Gene Namemultiple EGF-like-domains 9
SynonymsEgfl5, 4933405H16Rik
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.130) question?
Stock #IGL01697
Quality Score
Status
Chromosome4
Chromosomal Location70427065-70534995 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to A at 70433472 bp
ZygosityHeterozygous
Amino Acid Change Threonine to Serine at position 471 (T471S)
Ref Sequence ENSEMBL: ENSMUSP00000102982 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000107359]
Predicted Effect possibly damaging
Transcript: ENSMUST00000107359
AA Change: T471S

PolyPhen 2 Score 0.650 (Sensitivity: 0.87; Specificity: 0.91)
SMART Domains Protein: ENSMUSP00000102982
Gene: ENSMUSG00000039270
AA Change: T471S

DomainStartEndE-ValueType
signal peptide 1 34 N/A INTRINSIC
low complexity region 150 166 N/A INTRINSIC
low complexity region 183 199 N/A INTRINSIC
EGF_Lam 202 249 2.8e-9 SMART
TNFR 236 272 1.26e-1 SMART
EGF_Lam 252 296 2.13e-9 SMART
EGF_Lam 299 344 1.42e-10 SMART
EGF_Lam 347 395 6.3e-3 SMART
EGF_Lam 398 447 3.05e-10 SMART
transmembrane domain 513 535 N/A INTRINSIC
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 30 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
9430015G10Rik T A 4: 156,119,156 probably benign Het
Arid2 A C 15: 96,361,572 probably null Het
Cadm1 C A 9: 47,850,324 D435E probably damaging Het
Dagla A G 19: 10,271,198 F33L probably benign Het
Edrf1 A G 7: 133,643,730 H199R probably benign Het
F5 T A 1: 164,194,052 N1365K probably benign Het
Fam205c T A 4: 42,874,163 M2L probably benign Het
Gipc2 T G 3: 152,137,608 I131L probably benign Het
Gpc1 C T 1: 92,858,410 S507F possibly damaging Het
Grid1 A G 14: 35,309,257 D269G probably benign Het
Ighv12-3 A T 12: 114,366,953 M1K probably null Het
Kif5b T C 18: 6,226,871 H129R possibly damaging Het
Lipo3 A T 19: 33,559,565 C252S probably damaging Het
Mast4 A C 13: 102,767,893 N645K probably damaging Het
Mmrn1 A G 6: 60,976,493 D586G possibly damaging Het
Ninl A T 2: 150,939,947 L1206Q probably damaging Het
Olfr1446 T A 19: 12,890,467 T37S probably benign Het
Olfr45 T C 7: 140,691,652 V249A possibly damaging Het
Olfr765 C A 10: 129,046,502 C187F probably damaging Het
Oog2 T A 4: 144,195,184 N221K possibly damaging Het
Pik3ap1 G A 19: 41,324,579 A365V probably damaging Het
Ppwd1 T C 13: 104,220,464 E181G probably benign Het
Scaf11 A C 15: 96,423,623 probably benign Het
Skint7 T A 4: 111,980,457 probably benign Het
Sox14 T C 9: 99,875,663 I8V probably benign Het
Stim1 A T 7: 102,425,969 probably benign Het
Ttc37 C T 13: 76,128,733 L479F probably benign Het
Ttll3 T C 6: 113,399,729 S357P probably benign Het
Vmn1r178 T A 7: 23,893,689 I54N probably damaging Het
Zdhhc2 T C 8: 40,467,419 probably benign Het
Other mutations in Megf9
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01604:Megf9 APN 4 70448791 missense probably null 1.00
IGL03291:Megf9 APN 4 70488150 missense probably benign 0.05
R0020:Megf9 UTSW 4 70488149 missense probably benign 0.45
R0325:Megf9 UTSW 4 70455941 missense probably damaging 1.00
R0542:Megf9 UTSW 4 70435348 missense probably benign
R1144:Megf9 UTSW 4 70534624 missense probably benign 0.10
R1843:Megf9 UTSW 4 70534785 missense probably damaging 1.00
R2085:Megf9 UTSW 4 70448767 missense probably damaging 1.00
R2168:Megf9 UTSW 4 70433442 missense probably damaging 0.99
R4656:Megf9 UTSW 4 70448767 missense probably damaging 1.00
R4718:Megf9 UTSW 4 70448778 missense possibly damaging 0.49
R4832:Megf9 UTSW 4 70534428 missense probably damaging 0.99
R6573:Megf9 UTSW 4 70488172 nonsense probably null
R6978:Megf9 UTSW 4 70433529 missense probably benign 0.12
R7243:Megf9 UTSW 4 70435471 missense probably benign 0.03
R7481:Megf9 UTSW 4 70433442 missense probably damaging 0.99
R8063:Megf9 UTSW 4 70488258 missense probably damaging 1.00
R8460:Megf9 UTSW 4 70455971 missense probably damaging 1.00
R8746:Megf9 UTSW 4 70435274 missense probably damaging 1.00
Posted On2014-01-21