Mutagenetix > Incidental Mutations

Incidental Mutation 'IGL01700:Zfp831'

104428

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Zfp831

Ensembl Gene

ENSMUSG00000050600

Gene Name

zinc finger protein 831

Synonyms

ENSMUSG00000050600, OTTMUSG00000017459

Accession Numbers

Genbank: NM_001099328; MGI: 3641861

Is this an essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL01700

Quality Score

Status

Chromosome

Chromosomal Location

174643534-174710832 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

C to A at 174644918 bp

Zygosity

Heterozygous

Amino Acid Change

Threonine to Lysine at position 462 (T462K)

Ref Sequence

ENSEMBL: ENSMUSP00000060255 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000059452]

Predicted Effect

possibly damaging
Transcript: ENSMUST00000059452
AA Change: T462K

PolyPhen 2 Score 0.861 (Sensitivity: 0.83; Specificity: 0.93)

SMART Domains

Protein: ENSMUSP00000060255
Gene: ENSMUSG00000050600
AA Change: T462K

Domain	Start	End	E-Value	Type
low complexity region	120	135	N/A	INTRINSIC
ZnF_C2H2	143	165	5.06e-2	SMART
ZnF_C2H2	171	195	7.78e-3	SMART
low complexity region	201	216	N/A	INTRINSIC
low complexity region	237	248	N/A	INTRINSIC
low complexity region	345	371	N/A	INTRINSIC
low complexity region	383	392	N/A	INTRINSIC
low complexity region	447	459	N/A	INTRINSIC
low complexity region	645	657	N/A	INTRINSIC
low complexity region	717	736	N/A	INTRINSIC
low complexity region	856	870	N/A	INTRINSIC
low complexity region	1520	1529	N/A	INTRINSIC

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 37 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abca12	T	A	1: 71,280,390	M1778L	probably benign	Het
Aldh6a1	C	T	12: 84,439,538	C202Y	probably damaging	Het
Ankrd36	A	G	11: 5,632,198	T276A	probably benign	Het
Ankrd55	T	C	13: 112,381,168	I556T	probably benign	Het
Aqp4	A	G	18: 15,399,865	I57T	probably benign	Het
Atp1a1	T	C	3: 101,594,258	D43G	possibly damaging	Het
Cyld	G	A	8: 88,707,099	R172H	probably damaging	Het
Diexf	G	A	1: 193,118,265	P416S	probably damaging	Het
Ear2	A	T	14: 44,103,259	R125*	probably null	Het
Efcab9	T	C	11: 32,527,451	R24G	probably damaging	Het
F7	C	A	8: 13,028,685	Q39K	probably benign	Het
Galntl6	A	T	8: 57,958,460		probably benign	Het
Kcnj5	A	G	9: 32,322,629	V130A	probably damaging	Het
Magee2	A	G	X: 104,855,968	I359T	possibly damaging	Het
Myh1	T	G	11: 67,211,412	I843S	probably damaging	Het
Nfat5	T	A	8: 107,339,130	M98K	probably damaging	Het
Nrip3	T	A	7: 109,761,867	N200I	possibly damaging	Het
Olfr818	A	T	10: 129,945,941	N40K	probably damaging	Het
Phkb	A	T	8: 86,017,465	Q581L	probably benign	Het
Plxdc2	T	C	2: 16,512,115	V69A	probably benign	Het
Pou3f1	G	T	4: 124,658,857	W384L	probably damaging	Het
Prrc2a	G	A	17: 35,150,667	S1890L	possibly damaging	Het
Psmc1	C	A	12: 100,113,078	P27H	probably damaging	Het
Pvr	C	A	7: 19,909,232	A359S	probably benign	Het
Rasal1	A	T	5: 120,676,817	I711F	probably benign	Het
Ror1	C	T	4: 100,409,771	A223V	probably damaging	Het
Slc22a16	A	T	10: 40,603,908	I638L	unknown	Het
Slfn10-ps	C	T	11: 83,029,112		noncoding transcript	Het
Sptbn4	A	G	7: 27,404,268	L1176P	probably damaging	Het
Usp21	A	T	1: 171,283,402	F421I	probably damaging	Het
Vmn1r61	T	A	7: 5,611,203	R37S	possibly damaging	Het
Vps13a	G	A	19: 16,744,857	R364*	probably null	Het
Vps29	A	G	5: 122,362,867	Y165C	probably damaging	Het
Wdfy4	T	C	14: 33,020,238		probably benign	Het
Wdr24	A	G	17: 25,825,828	D219G	probably damaging	Het
Xpo1	T	C	11: 23,276,422		probably benign	Het
Zswim5	T	C	4: 116,986,461		probably benign	Het

Other mutations in Zfp831

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00089:Zfp831	APN	2	174646285	missense	possibly damaging	0.86
IGL00091:Zfp831	APN	2	174645658	missense	possibly damaging	0.73
IGL00764:Zfp831	APN	2	174645908	missense	possibly damaging	0.72
IGL01538:Zfp831	APN	2	174644606	missense	possibly damaging	0.72
IGL01718:Zfp831	APN	2	174643838	missense	possibly damaging	0.86
IGL02221:Zfp831	APN	2	174643726	missense	probably benign	0.33
IGL02250:Zfp831	APN	2	174648201	missense	possibly damaging	0.53
IGL03209:Zfp831	APN	2	174645266	missense	probably benign	0.40
D4043:Zfp831	UTSW	2	174645266	missense	probably benign	0.40
FR4304:Zfp831	UTSW	2	174645481	small insertion	probably benign
FR4340:Zfp831	UTSW	2	174645480	small insertion	probably benign
FR4449:Zfp831	UTSW	2	174645471	small insertion	probably benign
FR4449:Zfp831	UTSW	2	174645482	small insertion	probably benign
FR4589:Zfp831	UTSW	2	174645468	small insertion	probably benign
FR4737:Zfp831	UTSW	2	174645471	small insertion	probably benign
FR4737:Zfp831	UTSW	2	174645476	small insertion	probably benign
FR4737:Zfp831	UTSW	2	174645483	small insertion	probably benign
IGL02802:Zfp831	UTSW	2	174645152	missense	possibly damaging	0.73
P0028:Zfp831	UTSW	2	174645346	missense	possibly damaging	0.53
PIT4531001:Zfp831	UTSW	2	174646723	missense	possibly damaging	0.90
R0631:Zfp831	UTSW	2	174645290	missense	possibly damaging	0.53
R0644:Zfp831	UTSW	2	174645863	missense	probably benign	0.33
R0782:Zfp831	UTSW	2	174646630	missense	probably benign	0.06
R1156:Zfp831	UTSW	2	174646917	missense	possibly damaging	0.53
R1280:Zfp831	UTSW	2	174704059	missense	probably benign	0.00
R1709:Zfp831	UTSW	2	174645890	missense	probably benign	0.33
R1883:Zfp831	UTSW	2	174704077	missense	possibly damaging	0.53
R1884:Zfp831	UTSW	2	174704077	missense	possibly damaging	0.53
R2127:Zfp831	UTSW	2	174648124	missense	probably benign	0.33
R2137:Zfp831	UTSW	2	174705746	missense	possibly damaging	0.53
R2268:Zfp831	UTSW	2	174644241	missense	probably benign	0.01
R2330:Zfp831	UTSW	2	174648089	nonsense	probably null
R3547:Zfp831	UTSW	2	174657683	missense	probably benign
R3821:Zfp831	UTSW	2	174644023	missense	possibly damaging	0.73
R4163:Zfp831	UTSW	2	174644029	missense	possibly damaging	0.53
R4232:Zfp831	UTSW	2	174705654	missense	possibly damaging	0.96
R4778:Zfp831	UTSW	2	174646807	missense	possibly damaging	0.53
R4820:Zfp831	UTSW	2	174705304	missense	possibly damaging	0.73
R4912:Zfp831	UTSW	2	174644624	missense	probably damaging	1.00
R5119:Zfp831	UTSW	2	174705310	missense	probably benign	0.18
R5152:Zfp831	UTSW	2	174644564	missense	probably benign	0.33
R5723:Zfp831	UTSW	2	174645407	missense	probably benign	0.23
R5741:Zfp831	UTSW	2	174645152	missense	possibly damaging	0.73
R5888:Zfp831	UTSW	2	174643627	missense	probably benign	0.18
R5975:Zfp831	UTSW	2	174644092	missense	possibly damaging	0.93
R6092:Zfp831	UTSW	2	174705506	missense	probably damaging	0.98
R6158:Zfp831	UTSW	2	174643858	missense	possibly damaging	0.53
R6212:Zfp831	UTSW	2	174645868	missense	possibly damaging	0.53
R6233:Zfp831	UTSW	2	174646697	missense	possibly damaging	0.85
R6248:Zfp831	UTSW	2	174644515	missense	possibly damaging	0.53
R6255:Zfp831	UTSW	2	174646421	missense	possibly damaging	0.96
R6460:Zfp831	UTSW	2	174646567	missense	possibly damaging	0.46
R6477:Zfp831	UTSW	2	174704167	missense	probably benign
R6864:Zfp831	UTSW	2	174646740	missense	possibly damaging	0.72
R7396:Zfp831	UTSW	2	174645209	missense	possibly damaging	0.73
R7447:Zfp831	UTSW	2	174646103	missense	possibly damaging	0.88
R7499:Zfp831	UTSW	2	174644023	missense	possibly damaging	0.73
R7662:Zfp831	UTSW	2	174646141	missense	possibly damaging	0.85
R7857:Zfp831	UTSW	2	174705242	missense	probably benign	0.33
R7889:Zfp831	UTSW	2	174645304	missense	possibly damaging	0.53
R7896:Zfp831	UTSW	2	174647128	missense	possibly damaging	0.53
R8074:Zfp831	UTSW	2	174644735	missense	possibly damaging	0.72
R8089:Zfp831	UTSW	2	174644924	missense	possibly damaging	0.96
R8438:Zfp831	UTSW	2	174645003	missense	possibly damaging	0.53
X0021:Zfp831	UTSW	2	174705869	missense	possibly damaging	0.85
Z1177:Zfp831	UTSW	2	174644188	missense	possibly damaging	0.93

Posted On

2014-01-21