Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01702:Tnp1'

104515

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Tnp1

Ensembl Gene

ENSMUSG00000026182

Gene Name

transition protein 1

Synonyms

Tp-1, Stp-1, TP1

Accession Numbers

Essential gene?

Not available question?

Stock #

IGL01702

Quality Score

Status

Chromosome

Chromosomal Location

73054233-73055058 bp(-) (GRCm39)

Type of Mutation

splice site

DNA Base Change (assembly)

C to A at 73054877 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000027374 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000027374]

AlphaFold

P10856

Predicted Effect

probably benign
Transcript: ENSMUST00000027374

SMART Domains

Protein: ENSMUSP00000027374
Gene: ENSMUSG00000026182

Domain	Start	End	E-Value	Type
Pfam:TP1	2	52	1.7e-33	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000185768

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000188793

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000191122

Coding Region Coverage

Validation Efficiency

MGI Phenotype

PHENOTYPE: A portion of male homozygous null mice are infertile, exhibting defects in spermatogenesis and sperm motility. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 20 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Apol7a	T	C	15: 77,273,886 (GRCm39)		probably null	Het
Asb2	C	T	12: 103,302,164 (GRCm39)	G128E	possibly damaging	Het
Atp11c	A	T	X: 59,315,263 (GRCm39)	S683T	probably damaging	Het
Brinp3	A	G	1: 146,627,735 (GRCm39)		probably benign	Het
Cpeb3	A	T	19: 37,103,782 (GRCm39)	M369K	possibly damaging	Het
Exoc5	A	T	14: 49,253,072 (GRCm39)	C580*	probably null	Het
Gm9956	A	G	10: 56,621,335 (GRCm39)			Het
Gzmk	C	T	13: 113,317,084 (GRCm39)	V32I	probably damaging	Het
Hsf4	T	C	8: 105,998,221 (GRCm39)	I129T	probably damaging	Het
Igkv1-115	T	A	6: 68,138,516 (GRCm39)	W40R	probably damaging	Het
Iqub	A	T	6: 24,500,312 (GRCm39)	M314K	probably benign	Het
Krt87	T	C	15: 101,389,099 (GRCm39)	T78A	probably benign	Het
Med28	T	C	5: 45,682,633 (GRCm39)	S100P	probably benign	Het
Prx	G	A	7: 27,219,212 (GRCm39)	V1238I	probably benign	Het
Ptprq	T	C	10: 107,353,727 (GRCm39)	N2263S	probably benign	Het
Rab12	A	G	17: 66,826,384 (GRCm39)	F61S	probably damaging	Het
Serpinb9d	T	C	13: 33,387,006 (GRCm39)	F358S	probably damaging	Het
Slc25a3	A	T	10: 90,953,987 (GRCm39)	Y242N	probably damaging	Het
Smtnl1	T	C	2: 84,649,034 (GRCm39)	I73M	possibly damaging	Het
Trim5	T	C	7: 103,928,638 (GRCm39)	E101G	probably damaging	Het

Other mutations in Tnp1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL03193:Tnp1	APN	1	73,054,923 (GRCm39)	missense	probably damaging	0.99

Posted On

2014-01-21