Incidental Mutation 'IGL01705:Cd5'
ID104580
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Cd5
Ensembl Gene ENSMUSG00000024669
Gene NameCD5 antigen
SynonymsLyt-1, Ly-1, Ly-A, Ly-12
Accession Numbers
Is this an essential gene? Non essential (E-score: 0.000) question?
Stock #IGL01705
Quality Score
Status
Chromosome19
Chromosomal Location10718143-10738974 bp(-) (GRCm38)
Type of Mutationcritical splice donor site (2 bp from exon)
DNA Base Change (assembly) A to T at 10726295 bp
ZygosityHeterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000025571 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000025571]
Predicted Effect probably null
Transcript: ENSMUST00000025571
SMART Domains Protein: ENSMUSP00000025571
Gene: ENSMUSG00000024669

DomainStartEndE-ValueType
signal peptide 1 18 N/A INTRINSIC
SR 34 133 7.43e-19 SMART
low complexity region 138 157 N/A INTRINSIC
SR 276 367 7.27e-4 SMART
transmembrane domain 379 401 N/A INTRINSIC
low complexity region 402 415 N/A INTRINSIC
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the scavenger receptor cysteine-rich (SRCR) superfamily. Members of this family are secreted or membrane-anchored proteins mainly found in cells associated with the immune system. This protein is a type-I transmembrane glycoprotein found on the surface of thymocytes, T lymphocytes and a subset of B lymphocytes. The encoded protein contains three SRCR domains and may act as a receptor to regulate T-cell proliferation. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2016]
PHENOTYPE: Homozygous mutation of this gene does not result in a phenotype. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 31 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adamts19 A G 18: 59,032,966 T1077A possibly damaging Het
Akap13 T C 7: 75,746,767 V2504A possibly damaging Het
Anks3 A T 16: 4,947,723 W172R probably benign Het
Asap2 T A 12: 21,249,368 N633K possibly damaging Het
Astn1 A T 1: 158,504,313 S326C probably damaging Het
Cachd1 A G 4: 100,983,539 K900E possibly damaging Het
D130043K22Rik T A 13: 24,857,941 N284K probably benign Het
Dtna C T 18: 23,545,731 A38V probably damaging Het
Eny2 C A 15: 44,432,435 probably null Het
Grm5 A G 7: 88,130,046 Q930R possibly damaging Het
Igkv4-73 A T 6: 69,197,725 noncoding transcript Het
Lama2 A T 10: 27,189,274 probably benign Het
Lipg A G 18: 74,947,971 probably null Het
Mettl7b T A 10: 128,958,862 I198F probably benign Het
Neto2 T C 8: 85,641,003 K371E probably damaging Het
Olfr965 T C 9: 39,719,581 M118T possibly damaging Het
Paxbp1 A G 16: 91,016,988 F834L probably benign Het
Paxip1 A T 5: 27,748,859 S946R probably damaging Het
Pclo A G 5: 14,677,865 probably benign Het
Plcg2 T C 8: 117,581,662 L331P probably damaging Het
Reep1 A G 6: 71,773,288 T95A probably damaging Het
Rfx2 A G 17: 56,785,303 Y332H possibly damaging Het
Smchd1 A T 17: 71,381,398 D1288E probably damaging Het
Spag17 A G 3: 100,022,730 M582V probably benign Het
Susd1 A G 4: 59,332,931 probably benign Het
Syt9 T G 7: 107,436,352 L192R probably damaging Het
Tlr6 T C 5: 64,954,130 K478R probably benign Het
Tmem115 G T 9: 107,535,204 L242F probably benign Het
Tnfaip1 T C 11: 78,525,468 D263G probably benign Het
Ubqln3 T A 7: 104,142,677 I69F probably damaging Het
Vps52 T C 17: 33,966,068 L712P probably damaging Het
Other mutations in Cd5
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL03392:Cd5 APN 19 10726289 splice site probably benign
PIT4305001:Cd5 UTSW 19 10726386 missense possibly damaging 0.72
R0732:Cd5 UTSW 19 10723285 missense probably damaging 1.00
R1831:Cd5 UTSW 19 10719569 missense probably damaging 1.00
R2086:Cd5 UTSW 19 10723256 missense probably benign 0.00
R4184:Cd5 UTSW 19 10721274 missense probably damaging 1.00
R6162:Cd5 UTSW 19 10725880 missense probably damaging 1.00
R6894:Cd5 UTSW 19 10738839 missense possibly damaging 0.91
R7138:Cd5 UTSW 19 10720304 missense probably damaging 1.00
R7653:Cd5 UTSW 19 10726546 missense probably benign 0.00
R8297:Cd5 UTSW 19 10720245 missense probably damaging 1.00
R8408:Cd5 UTSW 19 10723105 missense possibly damaging 0.89
R8411:Cd5 UTSW 19 10720221 missense probably damaging 1.00
Posted On2014-01-21