Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01705:Cd5'

104580

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Cd5

Ensembl Gene

ENSMUSG00000024669

Gene Name

CD5 antigen

Synonyms

Ly-A, Ly-1, Ly-12, Lyt-1

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL01705

Quality Score

Status

Chromosome

Chromosomal Location

10695471-10716390 bp(-) (GRCm39)

Type of Mutation

critical splice donor site (2 bp from exon)

DNA Base Change (assembly)

A to T at 10703659 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000025571 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000025571]

AlphaFold

P13379

Predicted Effect

probably null
Transcript: ENSMUST00000025571

SMART Domains

Protein: ENSMUSP00000025571
Gene: ENSMUSG00000024669

Domain	Start	End	E-Value	Type
signal peptide	1	18	N/A	INTRINSIC
SR	34	133	7.43e-19	SMART
low complexity region	138	157	N/A	INTRINSIC
SR	276	367	7.27e-4	SMART
transmembrane domain	379	401	N/A	INTRINSIC
low complexity region	402	415	N/A	INTRINSIC

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the scavenger receptor cysteine-rich (SRCR) superfamily. Members of this family are secreted or membrane-anchored proteins mainly found in cells associated with the immune system. This protein is a type-I transmembrane glycoprotein found on the surface of thymocytes, T lymphocytes and a subset of B lymphocytes. The encoded protein contains three SRCR domains and may act as a receptor to regulate T-cell proliferation. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2016]
PHENOTYPE: Homozygous mutation of this gene does not result in a phenotype. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 31 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adamts19	A	G	18: 59,166,038 (GRCm39)	T1077A	possibly damaging	Het
Akap13	T	C	7: 75,396,515 (GRCm39)	V2504A	possibly damaging	Het
Anks3	A	T	16: 4,765,587 (GRCm39)	W172R	probably benign	Het
Asap2	T	A	12: 21,299,369 (GRCm39)	N633K	possibly damaging	Het
Astn1	A	T	1: 158,331,883 (GRCm39)	S326C	probably damaging	Het
Cachd1	A	G	4: 100,840,736 (GRCm39)	K900E	possibly damaging	Het
D130043K22Rik	T	A	13: 25,041,924 (GRCm39)	N284K	probably benign	Het
Dtna	C	T	18: 23,678,788 (GRCm39)	A38V	probably damaging	Het
Eny2	C	A	15: 44,295,831 (GRCm39)		probably null	Het
Grm5	A	G	7: 87,779,254 (GRCm39)	Q930R	possibly damaging	Het
Igkv4-73	A	T	6: 69,174,709 (GRCm39)		noncoding transcript	Het
Lama2	A	T	10: 27,065,270 (GRCm39)		probably benign	Het
Lipg	A	G	18: 75,081,042 (GRCm39)		probably null	Het
Neto2	T	C	8: 86,367,632 (GRCm39)	K371E	probably damaging	Het
Or8g52	T	C	9: 39,630,877 (GRCm39)	M118T	possibly damaging	Het
Paxbp1	A	G	16: 90,813,876 (GRCm39)	F834L	probably benign	Het
Paxip1	A	T	5: 27,953,857 (GRCm39)	S946R	probably damaging	Het
Pclo	A	G	5: 14,727,879 (GRCm39)		probably benign	Het
Plcg2	T	C	8: 118,308,401 (GRCm39)	L331P	probably damaging	Het
Reep1	A	G	6: 71,750,272 (GRCm39)	T95A	probably damaging	Het
Rfx2	A	G	17: 57,092,303 (GRCm39)	Y332H	possibly damaging	Het
Smchd1	A	T	17: 71,688,393 (GRCm39)	D1288E	probably damaging	Het
Spag17	A	G	3: 99,930,046 (GRCm39)	M582V	probably benign	Het
Susd1	A	G	4: 59,332,931 (GRCm39)		probably benign	Het
Syt9	T	G	7: 107,035,559 (GRCm39)	L192R	probably damaging	Het
Tlr6	T	C	5: 65,111,473 (GRCm39)	K478R	probably benign	Het
Tmem115	G	T	9: 107,412,403 (GRCm39)	L242F	probably benign	Het
Tmt1b	T	A	10: 128,794,731 (GRCm39)	I198F	probably benign	Het
Tnfaip1	T	C	11: 78,416,294 (GRCm39)	D263G	probably benign	Het
Ubqln3	T	A	7: 103,791,884 (GRCm39)	I69F	probably damaging	Het
Vps52	T	C	17: 34,185,042 (GRCm39)	L712P	probably damaging	Het

Other mutations in Cd5

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL03392:Cd5	APN	19	10,703,653 (GRCm39)	splice site	probably benign
PIT4305001:Cd5	UTSW	19	10,703,750 (GRCm39)	missense	possibly damaging	0.72
R0732:Cd5	UTSW	19	10,700,649 (GRCm39)	missense	probably damaging	1.00
R1831:Cd5	UTSW	19	10,696,933 (GRCm39)	missense	probably damaging	1.00
R2086:Cd5	UTSW	19	10,700,620 (GRCm39)	missense	probably benign	0.00
R4184:Cd5	UTSW	19	10,698,638 (GRCm39)	missense	probably damaging	1.00
R6162:Cd5	UTSW	19	10,703,244 (GRCm39)	missense	probably damaging	1.00
R6894:Cd5	UTSW	19	10,716,203 (GRCm39)	missense	possibly damaging	0.91
R7138:Cd5	UTSW	19	10,697,668 (GRCm39)	missense	probably damaging	1.00
R7653:Cd5	UTSW	19	10,703,910 (GRCm39)	missense	probably benign	0.00
R8297:Cd5	UTSW	19	10,697,609 (GRCm39)	missense	probably damaging	1.00
R8408:Cd5	UTSW	19	10,700,469 (GRCm39)	missense	possibly damaging	0.89
R8411:Cd5	UTSW	19	10,697,585 (GRCm39)	missense	probably damaging	1.00
R8699:Cd5	UTSW	19	10,702,556 (GRCm39)	missense	possibly damaging	0.67
R9663:Cd5	UTSW	19	10,703,858 (GRCm39)	missense	probably benign	0.10

Posted On

2014-01-21