Incidental Mutation 'IGL00765:Eif3e'
ID10463
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Eif3e
Ensembl Gene ENSMUSG00000022336
Gene Nameeukaryotic translation initiation factor 3, subunit E
SynonymsEif3s6, eIF3-p46, 48kDa, Int6, eIF3-p48
Accession Numbers
Is this an essential gene? Probably essential (E-score: 0.961) question?
Stock #IGL00765
Quality Score
Status
Chromosome15
Chromosomal Location43250058-43282719 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to T at 43278349 bp
ZygosityHeterozygous
Amino Acid Change Methionine to Lysine at position 55 (M55K)
Ref Sequence ENSEMBL: ENSMUSP00000022960 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000022960]
Predicted Effect probably benign
Transcript: ENSMUST00000022960
AA Change: M55K

PolyPhen 2 Score 0.170 (Sensitivity: 0.92; Specificity: 0.87)
SMART Domains Protein: ENSMUSP00000022960
Gene: ENSMUSG00000022336
AA Change: M55K

DomainStartEndE-ValueType
eIF3_N 5 138 4.88e-70 SMART
Blast:eIF3_N 157 193 2e-14 BLAST
Blast:PINT 218 251 7e-9 BLAST
Blast:PINT 284 315 3e-13 BLAST
PINT 327 411 8.17e-19 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000226415
Predicted Effect noncoding transcript
Transcript: ENSMUST00000228892
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 22 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcc1 C T 16: 14,411,508 T368I probably damaging Het
Bub1 T A 2: 127,829,472 N64I probably damaging Het
Ccdc97 A G 7: 25,714,852 L159P probably damaging Het
Chrnd T C 1: 87,195,709 V214A probably damaging Het
Csf2rb2 A G 15: 78,292,716 S185P probably benign Het
Dmxl2 A G 9: 54,415,422 probably benign Het
Ercc6l2 T C 13: 63,848,772 V365A possibly damaging Het
Fndc1 A G 17: 7,772,693 S724P unknown Het
Htt T C 5: 34,877,425 probably benign Het
Ints4 C T 7: 97,535,205 T839I probably damaging Het
Lrp6 T G 6: 134,541,854 T83P probably benign Het
Lrrc8d C T 5: 105,811,952 T76I possibly damaging Het
Nae1 T C 8: 104,517,950 probably benign Het
Nlrp14 T C 7: 107,190,139 V45A possibly damaging Het
Nrp2 C A 1: 62,704,251 S16* probably null Het
Nup155 T C 15: 8,153,228 I1225T probably benign Het
Pnpla7 G T 2: 24,980,224 A43S probably damaging Het
Prcp T C 7: 92,933,099 S431P probably benign Het
Rbck1 A G 2: 152,330,954 probably benign Het
Smg8 T C 11: 87,078,041 E963G probably damaging Het
Tanc1 A C 2: 59,806,301 M836L probably benign Het
Tnpo1 A G 13: 98,850,104 probably benign Het
Other mutations in Eif3e
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02333:Eif3e APN 15 43266137 missense probably benign 0.37
IGL02669:Eif3e APN 15 43282692 start codon destroyed probably benign
IGL03119:Eif3e APN 15 43265604 missense probably benign
IGL03200:Eif3e APN 15 43252261 missense probably damaging 1.00
Verdugo UTSW 15 43272289 missense probably benign 0.29
R0152:Eif3e UTSW 15 43252236 missense possibly damaging 0.83
R1439:Eif3e UTSW 15 43278428 splice site probably benign
R1613:Eif3e UTSW 15 43250224 missense possibly damaging 0.81
R1997:Eif3e UTSW 15 43265609 missense probably damaging 1.00
R2221:Eif3e UTSW 15 43251547 missense possibly damaging 0.95
R3761:Eif3e UTSW 15 43261084 missense probably damaging 0.99
R4241:Eif3e UTSW 15 43262690 missense probably damaging 0.97
R4571:Eif3e UTSW 15 43266162 missense possibly damaging 0.74
R5061:Eif3e UTSW 15 43252261 missense probably damaging 1.00
R5227:Eif3e UTSW 15 43251521 missense probably benign 0.01
R5367:Eif3e UTSW 15 43252304 missense probably damaging 1.00
R5417:Eif3e UTSW 15 43265521 missense probably benign 0.00
R5497:Eif3e UTSW 15 43270970 missense probably damaging 0.98
R5928:Eif3e UTSW 15 43275332 splice site probably null
R6083:Eif3e UTSW 15 43266144 missense probably damaging 1.00
R6337:Eif3e UTSW 15 43252296 missense possibly damaging 0.95
R6964:Eif3e UTSW 15 43272289 missense probably benign 0.29
R7692:Eif3e UTSW 15 43263246 missense probably damaging 0.98
R7825:Eif3e UTSW 15 43266271 splice site probably null
R8034:Eif3e UTSW 15 43272307 missense probably benign 0.02
Posted On2012-12-06