Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01707:Ttc41'

104631

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Ttc41

Ensembl Gene

ENSMUSG00000044937

Gene Name

tetratricopeptide repeat domain 41

Synonyms

Gnn, BC030307

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.146) question?

Stock #

IGL01707

Quality Score

Status

Chromosome

Chromosomal Location

86705811-86776844 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 86776767 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Arginine to Serine at position 1301 (R1301S)

Ref Sequence

ENSEMBL: ENSMUSP00000075059 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000075632] [ENSMUST00000099396]

AlphaFold

no structure available at present

Predicted Effect

probably damaging
Transcript: ENSMUST00000075632
AA Change: R1301S

PolyPhen 2 Score 0.996 (Sensitivity: 0.55; Specificity: 0.98)

SMART Domains

Protein: ENSMUSP00000075059
Gene: ENSMUSG00000044937
AA Change: R1301S

Domain	Start	End	E-Value	Type
low complexity region	216	229	N/A	INTRINSIC
low complexity region	307	315	N/A	INTRINSIC
Pfam:NACHT	337	515	5.4e-10	PFAM
SCOP:d1qqea_	805	1028	2e-5	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000099396

SMART Domains

Protein: ENSMUSP00000096994
Gene: ENSMUSG00000054027

Domain	Start	End	E-Value	Type
low complexity region	5	25	N/A	INTRINSIC
Pfam:5_nucleotid	83	526	1.8e-159	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000218802

Predicted Effect

probably benign
Transcript: ENSMUST00000219476

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 33 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Ablim1	C	A	19: 57,039,447	R404L	probably damaging	Het
Acot6	C	A	12: 84,100,989	S6R	probably benign	Het
Adamtsl4	T	A	3: 95,683,991	Q222L	probably benign	Het
Adgre5	T	A	8: 83,724,347	T725S	probably damaging	Het
Agbl3	A	T	6: 34,839,454	K766N	possibly damaging	Het
Ankrd12	A	G	17: 65,984,278	S1387P	probably damaging	Het
Camk2a	G	A	18: 60,960,050		probably null	Het
Cd209d	T	C	8: 3,878,296	I30V	probably benign	Het
Ces1d	A	T	8: 93,189,550	S150T	possibly damaging	Het
Cox4i2	T	C	2: 152,757,036	Y38H	probably damaging	Het
Csmd2	T	C	4: 128,383,005	Y867H	possibly damaging	Het
Dbh	G	A	2: 27,165,544	C10Y	probably benign	Het
Dnajc13	A	G	9: 104,228,979	V332A	probably damaging	Het
Gnb3	G	T	6: 124,839,689	A11E	possibly damaging	Het
Herc2	A	G	7: 56,165,187	R2725G	probably damaging	Het
Kdm4c	C	T	4: 74,336,927	L573F	probably damaging	Het
Kmt2c	T	A	5: 25,300,098	Q3404L	probably damaging	Het
Mmp9	A	G	2: 164,949,989	H231R	probably benign	Het
Nphp3	A	T	9: 104,018,158	D371V	possibly damaging	Het
Nphp4	A	G	4: 152,538,983	I705V	probably benign	Het
Nutm2	A	T	13: 50,469,717	N150I	probably damaging	Het
Olfr576	T	C	7: 102,965,919	I273T	probably damaging	Het
Olfr611	A	T	7: 103,517,934	I150N	probably damaging	Het
Phb2	A	G	6: 124,714,035	Q52R	probably benign	Het
Plekhh1	T	A	12: 79,078,964	V1258E	probably benign	Het
Pou2f1	A	T	1: 165,915,116	N69K	probably damaging	Het
Rapsn	T	A	2: 91,043,240	M297K	probably benign	Het
Senp5	A	C	16: 31,989,770	V195G	probably damaging	Het
Trim25	T	C	11: 88,999,691	V68A	probably damaging	Het
Vcan	T	C	13: 89,689,745	Y1600C	probably damaging	Het
Washc5	A	G	15: 59,342,015	I864T	possibly damaging	Het
Wif1	T	A	10: 121,083,985		probably null	Het
Zdhhc15	G	A	X: 104,565,816	R208C	probably damaging	Het

Other mutations in Ttc41

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00846:Ttc41	APN	10	86,736,933 (GRCm38)	missense	possibly damaging	0.71
IGL01373:Ttc41	APN	10	86,775,957 (GRCm38)	missense	possibly damaging	0.61
IGL01636:Ttc41	APN	10	86,776,678 (GRCm38)	missense	probably benign
IGL01814:Ttc41	APN	10	86,731,026 (GRCm38)	missense	probably damaging	0.98
IGL01845:Ttc41	APN	10	86,776,624 (GRCm38)	missense	probably benign	0.03
IGL01918:Ttc41	APN	10	86,713,190 (GRCm38)	missense	probably damaging	1.00
IGL02374:Ttc41	APN	10	86,775,951 (GRCm38)	missense	probably damaging	1.00
IGL02489:Ttc41	APN	10	86,760,914 (GRCm38)	nonsense	probably null
IGL02887:Ttc41	APN	10	86,733,654 (GRCm38)	missense	probably damaging	1.00
IGL03061:Ttc41	APN	10	86,736,857 (GRCm38)	missense	possibly damaging	0.65
IGL03077:Ttc41	APN	10	86,758,348 (GRCm38)	missense	probably damaging	1.00
IGL03210:Ttc41	APN	10	86,724,414 (GRCm38)	critical splice donor site	probably null
IGL03242:Ttc41	APN	10	86,776,819 (GRCm38)	makesense	probably null
IGL03307:Ttc41	APN	10	86,744,440 (GRCm38)	missense	possibly damaging	0.76
BB003:Ttc41	UTSW	10	86,776,047 (GRCm38)	missense	probably benign	0.10
BB013:Ttc41	UTSW	10	86,776,047 (GRCm38)	missense	probably benign	0.10
R0071:Ttc41	UTSW	10	86,736,846 (GRCm38)	missense	probably benign	0.01
R0071:Ttc41	UTSW	10	86,736,846 (GRCm38)	missense	probably benign	0.01
R0379:Ttc41	UTSW	10	86,712,977 (GRCm38)	missense	possibly damaging	0.65
R0384:Ttc41	UTSW	10	86,763,947 (GRCm38)	missense	probably damaging	1.00
R0545:Ttc41	UTSW	10	86,759,097 (GRCm38)	missense	probably benign	0.00
R1589:Ttc41	UTSW	10	86,776,390 (GRCm38)	missense	probably benign	0.01
R1599:Ttc41	UTSW	10	86,776,573 (GRCm38)	missense	probably benign	0.04
R1608:Ttc41	UTSW	10	86,775,993 (GRCm38)	missense	probably damaging	1.00
R1670:Ttc41	UTSW	10	86,776,252 (GRCm38)	missense	possibly damaging	0.93
R1938:Ttc41	UTSW	10	86,776,214 (GRCm38)	missense	probably benign
R2398:Ttc41	UTSW	10	86,713,386 (GRCm38)	missense	possibly damaging	0.91
R2401:Ttc41	UTSW	10	86,724,374 (GRCm38)	missense	probably benign	0.42
R3117:Ttc41	UTSW	10	86,724,320 (GRCm38)	missense	possibly damaging	0.62
R3119:Ttc41	UTSW	10	86,724,320 (GRCm38)	missense	possibly damaging	0.62
R4805:Ttc41	UTSW	10	86,729,798 (GRCm38)	missense	possibly damaging	0.62
R4840:Ttc41	UTSW	10	86,731,125 (GRCm38)	missense	probably benign	0.10
R4841:Ttc41	UTSW	10	86,731,125 (GRCm38)	missense	probably benign	0.10
R4842:Ttc41	UTSW	10	86,731,125 (GRCm38)	missense	probably benign	0.10
R4884:Ttc41	UTSW	10	86,731,018 (GRCm38)	missense	probably benign	0.00
R4885:Ttc41	UTSW	10	86,759,102 (GRCm38)	missense	possibly damaging	0.76
R4898:Ttc41	UTSW	10	86,776,192 (GRCm38)	missense	possibly damaging	0.80
R5067:Ttc41	UTSW	10	86,744,544 (GRCm38)	missense	probably damaging	0.96
R5253:Ttc41	UTSW	10	86,730,942 (GRCm38)	missense	probably benign	0.13
R5268:Ttc41	UTSW	10	86,744,478 (GRCm38)	missense	possibly damaging	0.76
R5297:Ttc41	UTSW	10	86,776,579 (GRCm38)	missense	probably benign	0.04
R5301:Ttc41	UTSW	10	86,719,520 (GRCm38)	missense	probably benign	0.00
R5425:Ttc41	UTSW	10	86,776,630 (GRCm38)	missense	probably damaging	0.96
R5567:Ttc41	UTSW	10	86,760,920 (GRCm38)	critical splice donor site	probably null
R5635:Ttc41	UTSW	10	86,736,977 (GRCm38)	missense	probably benign	0.09
R5752:Ttc41	UTSW	10	86,758,346 (GRCm38)	missense	probably benign	0.33
R5868:Ttc41	UTSW	10	86,750,264 (GRCm38)	missense	possibly damaging	0.70
R5948:Ttc41	UTSW	10	86,713,224 (GRCm38)	missense	probably damaging	1.00
R6116:Ttc41	UTSW	10	86,759,088 (GRCm38)	critical splice acceptor site	probably null
R6247:Ttc41	UTSW	10	86,776,663 (GRCm38)	missense	probably benign	0.00
R6260:Ttc41	UTSW	10	86,733,707 (GRCm38)	missense	probably benign	0.32
R6260:Ttc41	UTSW	10	86,731,159 (GRCm38)	missense	probably benign	0.20
R6276:Ttc41	UTSW	10	86,744,449 (GRCm38)	missense	probably benign	0.01
R6458:Ttc41	UTSW	10	86,758,270 (GRCm38)	missense	possibly damaging	0.45
R7170:Ttc41	UTSW	10	86,713,503 (GRCm38)	missense	probably benign	0.17
R7348:Ttc41	UTSW	10	86,750,348 (GRCm38)	nonsense	probably null
R7382:Ttc41	UTSW	10	86,776,510 (GRCm38)	missense	probably damaging	0.97
R7509:Ttc41	UTSW	10	86,713,432 (GRCm38)	missense	probably damaging	1.00
R7689:Ttc41	UTSW	10	86,759,224 (GRCm38)	missense	probably damaging	1.00
R7807:Ttc41	UTSW	10	86,776,631 (GRCm38)	missense	probably benign	0.02
R7926:Ttc41	UTSW	10	86,776,047 (GRCm38)	missense	probably benign	0.10
R7998:Ttc41	UTSW	10	86,736,847 (GRCm38)	missense	probably benign	0.01
R8021:Ttc41	UTSW	10	86,733,714 (GRCm38)	missense	probably benign
R8059:Ttc41	UTSW	10	86,712,978 (GRCm38)	missense	probably benign	0.01
R8170:Ttc41	UTSW	10	86,776,166 (GRCm38)	missense	probably damaging	1.00
R8303:Ttc41	UTSW	10	86,719,630 (GRCm38)	missense	probably benign	0.06
R8375:Ttc41	UTSW	10	86,763,980 (GRCm38)	missense	probably damaging	0.97
R8383:Ttc41	UTSW	10	86,719,526 (GRCm38)	missense	probably benign	0.00
R8698:Ttc41	UTSW	10	86,712,977 (GRCm38)	missense	probably benign	0.00
R8773:Ttc41	UTSW	10	86,729,815 (GRCm38)	missense	probably benign	0.35
R8902:Ttc41	UTSW	10	86,713,001 (GRCm38)	missense	probably benign	0.06
R8985:Ttc41	UTSW	10	86,731,092 (GRCm38)	missense	possibly damaging	0.80
R8988:Ttc41	UTSW	10	86,713,735 (GRCm38)	missense	possibly damaging	0.88
R9007:Ttc41	UTSW	10	86,733,761 (GRCm38)	missense	probably damaging	1.00
R9137:Ttc41	UTSW	10	86,776,622 (GRCm38)	missense	probably benign	0.22
R9236:Ttc41	UTSW	10	86,776,730 (GRCm38)	missense	probably damaging	1.00
R9248:Ttc41	UTSW	10	86,731,249 (GRCm38)	missense	probably benign	0.00
R9287:Ttc41	UTSW	10	86,763,966 (GRCm38)	missense	probably benign	0.43
R9345:Ttc41	UTSW	10	86,759,225 (GRCm38)	missense	probably damaging	0.99
R9386:Ttc41	UTSW	10	86,713,026 (GRCm38)	missense	probably damaging	0.99
R9500:Ttc41	UTSW	10	86,729,862 (GRCm38)	missense	probably benign	0.03
R9570:Ttc41	UTSW	10	86,713,734 (GRCm38)	missense	possibly damaging	0.88
R9593:Ttc41	UTSW	10	86,713,185 (GRCm38)	missense	probably benign	0.24
X0024:Ttc41	UTSW	10	86,724,250 (GRCm38)	missense	probably damaging	1.00
X0064:Ttc41	UTSW	10	86,729,797 (GRCm38)	missense	probably benign	0.01

Posted On

2014-01-21