Incidental Mutation 'IGL01707:Ttc41'
ID 104631
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Ttc41
Ensembl Gene ENSMUSG00000044937
Gene Name tetratricopeptide repeat domain 41
Synonyms Gnn, BC030307
Accession Numbers
Essential gene? Probably non essential (E-score: 0.146) question?
Stock # IGL01707
Quality Score
Status
Chromosome 10
Chromosomal Location 86705811-86776844 bp(+) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) A to T at 86776767 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Arginine to Serine at position 1301 (R1301S)
Ref Sequence ENSEMBL: ENSMUSP00000075059 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000075632] [ENSMUST00000099396]
AlphaFold no structure available at present
Predicted Effect probably damaging
Transcript: ENSMUST00000075632
AA Change: R1301S

PolyPhen 2 Score 0.996 (Sensitivity: 0.55; Specificity: 0.98)
SMART Domains Protein: ENSMUSP00000075059
Gene: ENSMUSG00000044937
AA Change: R1301S

DomainStartEndE-ValueType
low complexity region 216 229 N/A INTRINSIC
low complexity region 307 315 N/A INTRINSIC
Pfam:NACHT 337 515 5.4e-10 PFAM
SCOP:d1qqea_ 805 1028 2e-5 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000099396
SMART Domains Protein: ENSMUSP00000096994
Gene: ENSMUSG00000054027

DomainStartEndE-ValueType
low complexity region 5 25 N/A INTRINSIC
Pfam:5_nucleotid 83 526 1.8e-159 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000218802
Predicted Effect probably benign
Transcript: ENSMUST00000219476
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 33 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ablim1 C A 19: 57,039,447 R404L probably damaging Het
Acot6 C A 12: 84,100,989 S6R probably benign Het
Adamtsl4 T A 3: 95,683,991 Q222L probably benign Het
Adgre5 T A 8: 83,724,347 T725S probably damaging Het
Agbl3 A T 6: 34,839,454 K766N possibly damaging Het
Ankrd12 A G 17: 65,984,278 S1387P probably damaging Het
Camk2a G A 18: 60,960,050 probably null Het
Cd209d T C 8: 3,878,296 I30V probably benign Het
Ces1d A T 8: 93,189,550 S150T possibly damaging Het
Cox4i2 T C 2: 152,757,036 Y38H probably damaging Het
Csmd2 T C 4: 128,383,005 Y867H possibly damaging Het
Dbh G A 2: 27,165,544 C10Y probably benign Het
Dnajc13 A G 9: 104,228,979 V332A probably damaging Het
Gnb3 G T 6: 124,839,689 A11E possibly damaging Het
Herc2 A G 7: 56,165,187 R2725G probably damaging Het
Kdm4c C T 4: 74,336,927 L573F probably damaging Het
Kmt2c T A 5: 25,300,098 Q3404L probably damaging Het
Mmp9 A G 2: 164,949,989 H231R probably benign Het
Nphp3 A T 9: 104,018,158 D371V possibly damaging Het
Nphp4 A G 4: 152,538,983 I705V probably benign Het
Nutm2 A T 13: 50,469,717 N150I probably damaging Het
Olfr576 T C 7: 102,965,919 I273T probably damaging Het
Olfr611 A T 7: 103,517,934 I150N probably damaging Het
Phb2 A G 6: 124,714,035 Q52R probably benign Het
Plekhh1 T A 12: 79,078,964 V1258E probably benign Het
Pou2f1 A T 1: 165,915,116 N69K probably damaging Het
Rapsn T A 2: 91,043,240 M297K probably benign Het
Senp5 A C 16: 31,989,770 V195G probably damaging Het
Trim25 T C 11: 88,999,691 V68A probably damaging Het
Vcan T C 13: 89,689,745 Y1600C probably damaging Het
Washc5 A G 15: 59,342,015 I864T possibly damaging Het
Wif1 T A 10: 121,083,985 probably null Het
Zdhhc15 G A X: 104,565,816 R208C probably damaging Het
Other mutations in Ttc41
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00846:Ttc41 APN 10 86,736,933 (GRCm38) missense possibly damaging 0.71
IGL01373:Ttc41 APN 10 86,775,957 (GRCm38) missense possibly damaging 0.61
IGL01636:Ttc41 APN 10 86,776,678 (GRCm38) missense probably benign
IGL01814:Ttc41 APN 10 86,731,026 (GRCm38) missense probably damaging 0.98
IGL01845:Ttc41 APN 10 86,776,624 (GRCm38) missense probably benign 0.03
IGL01918:Ttc41 APN 10 86,713,190 (GRCm38) missense probably damaging 1.00
IGL02374:Ttc41 APN 10 86,775,951 (GRCm38) missense probably damaging 1.00
IGL02489:Ttc41 APN 10 86,760,914 (GRCm38) nonsense probably null
IGL02887:Ttc41 APN 10 86,733,654 (GRCm38) missense probably damaging 1.00
IGL03061:Ttc41 APN 10 86,736,857 (GRCm38) missense possibly damaging 0.65
IGL03077:Ttc41 APN 10 86,758,348 (GRCm38) missense probably damaging 1.00
IGL03210:Ttc41 APN 10 86,724,414 (GRCm38) critical splice donor site probably null
IGL03242:Ttc41 APN 10 86,776,819 (GRCm38) makesense probably null
IGL03307:Ttc41 APN 10 86,744,440 (GRCm38) missense possibly damaging 0.76
BB003:Ttc41 UTSW 10 86,776,047 (GRCm38) missense probably benign 0.10
BB013:Ttc41 UTSW 10 86,776,047 (GRCm38) missense probably benign 0.10
R0071:Ttc41 UTSW 10 86,736,846 (GRCm38) missense probably benign 0.01
R0071:Ttc41 UTSW 10 86,736,846 (GRCm38) missense probably benign 0.01
R0379:Ttc41 UTSW 10 86,712,977 (GRCm38) missense possibly damaging 0.65
R0384:Ttc41 UTSW 10 86,763,947 (GRCm38) missense probably damaging 1.00
R0545:Ttc41 UTSW 10 86,759,097 (GRCm38) missense probably benign 0.00
R1589:Ttc41 UTSW 10 86,776,390 (GRCm38) missense probably benign 0.01
R1599:Ttc41 UTSW 10 86,776,573 (GRCm38) missense probably benign 0.04
R1608:Ttc41 UTSW 10 86,775,993 (GRCm38) missense probably damaging 1.00
R1670:Ttc41 UTSW 10 86,776,252 (GRCm38) missense possibly damaging 0.93
R1938:Ttc41 UTSW 10 86,776,214 (GRCm38) missense probably benign
R2398:Ttc41 UTSW 10 86,713,386 (GRCm38) missense possibly damaging 0.91
R2401:Ttc41 UTSW 10 86,724,374 (GRCm38) missense probably benign 0.42
R3117:Ttc41 UTSW 10 86,724,320 (GRCm38) missense possibly damaging 0.62
R3119:Ttc41 UTSW 10 86,724,320 (GRCm38) missense possibly damaging 0.62
R4805:Ttc41 UTSW 10 86,729,798 (GRCm38) missense possibly damaging 0.62
R4840:Ttc41 UTSW 10 86,731,125 (GRCm38) missense probably benign 0.10
R4841:Ttc41 UTSW 10 86,731,125 (GRCm38) missense probably benign 0.10
R4842:Ttc41 UTSW 10 86,731,125 (GRCm38) missense probably benign 0.10
R4884:Ttc41 UTSW 10 86,731,018 (GRCm38) missense probably benign 0.00
R4885:Ttc41 UTSW 10 86,759,102 (GRCm38) missense possibly damaging 0.76
R4898:Ttc41 UTSW 10 86,776,192 (GRCm38) missense possibly damaging 0.80
R5067:Ttc41 UTSW 10 86,744,544 (GRCm38) missense probably damaging 0.96
R5253:Ttc41 UTSW 10 86,730,942 (GRCm38) missense probably benign 0.13
R5268:Ttc41 UTSW 10 86,744,478 (GRCm38) missense possibly damaging 0.76
R5297:Ttc41 UTSW 10 86,776,579 (GRCm38) missense probably benign 0.04
R5301:Ttc41 UTSW 10 86,719,520 (GRCm38) missense probably benign 0.00
R5425:Ttc41 UTSW 10 86,776,630 (GRCm38) missense probably damaging 0.96
R5567:Ttc41 UTSW 10 86,760,920 (GRCm38) critical splice donor site probably null
R5635:Ttc41 UTSW 10 86,736,977 (GRCm38) missense probably benign 0.09
R5752:Ttc41 UTSW 10 86,758,346 (GRCm38) missense probably benign 0.33
R5868:Ttc41 UTSW 10 86,750,264 (GRCm38) missense possibly damaging 0.70
R5948:Ttc41 UTSW 10 86,713,224 (GRCm38) missense probably damaging 1.00
R6116:Ttc41 UTSW 10 86,759,088 (GRCm38) critical splice acceptor site probably null
R6247:Ttc41 UTSW 10 86,776,663 (GRCm38) missense probably benign 0.00
R6260:Ttc41 UTSW 10 86,733,707 (GRCm38) missense probably benign 0.32
R6260:Ttc41 UTSW 10 86,731,159 (GRCm38) missense probably benign 0.20
R6276:Ttc41 UTSW 10 86,744,449 (GRCm38) missense probably benign 0.01
R6458:Ttc41 UTSW 10 86,758,270 (GRCm38) missense possibly damaging 0.45
R7170:Ttc41 UTSW 10 86,713,503 (GRCm38) missense probably benign 0.17
R7348:Ttc41 UTSW 10 86,750,348 (GRCm38) nonsense probably null
R7382:Ttc41 UTSW 10 86,776,510 (GRCm38) missense probably damaging 0.97
R7509:Ttc41 UTSW 10 86,713,432 (GRCm38) missense probably damaging 1.00
R7689:Ttc41 UTSW 10 86,759,224 (GRCm38) missense probably damaging 1.00
R7807:Ttc41 UTSW 10 86,776,631 (GRCm38) missense probably benign 0.02
R7926:Ttc41 UTSW 10 86,776,047 (GRCm38) missense probably benign 0.10
R7998:Ttc41 UTSW 10 86,736,847 (GRCm38) missense probably benign 0.01
R8021:Ttc41 UTSW 10 86,733,714 (GRCm38) missense probably benign
R8059:Ttc41 UTSW 10 86,712,978 (GRCm38) missense probably benign 0.01
R8170:Ttc41 UTSW 10 86,776,166 (GRCm38) missense probably damaging 1.00
R8303:Ttc41 UTSW 10 86,719,630 (GRCm38) missense probably benign 0.06
R8375:Ttc41 UTSW 10 86,763,980 (GRCm38) missense probably damaging 0.97
R8383:Ttc41 UTSW 10 86,719,526 (GRCm38) missense probably benign 0.00
R8698:Ttc41 UTSW 10 86,712,977 (GRCm38) missense probably benign 0.00
R8773:Ttc41 UTSW 10 86,729,815 (GRCm38) missense probably benign 0.35
R8902:Ttc41 UTSW 10 86,713,001 (GRCm38) missense probably benign 0.06
R8985:Ttc41 UTSW 10 86,731,092 (GRCm38) missense possibly damaging 0.80
R8988:Ttc41 UTSW 10 86,713,735 (GRCm38) missense possibly damaging 0.88
R9007:Ttc41 UTSW 10 86,733,761 (GRCm38) missense probably damaging 1.00
R9137:Ttc41 UTSW 10 86,776,622 (GRCm38) missense probably benign 0.22
R9236:Ttc41 UTSW 10 86,776,730 (GRCm38) missense probably damaging 1.00
R9248:Ttc41 UTSW 10 86,731,249 (GRCm38) missense probably benign 0.00
R9287:Ttc41 UTSW 10 86,763,966 (GRCm38) missense probably benign 0.43
R9345:Ttc41 UTSW 10 86,759,225 (GRCm38) missense probably damaging 0.99
R9386:Ttc41 UTSW 10 86,713,026 (GRCm38) missense probably damaging 0.99
R9500:Ttc41 UTSW 10 86,729,862 (GRCm38) missense probably benign 0.03
R9570:Ttc41 UTSW 10 86,713,734 (GRCm38) missense possibly damaging 0.88
R9593:Ttc41 UTSW 10 86,713,185 (GRCm38) missense probably benign 0.24
X0024:Ttc41 UTSW 10 86,724,250 (GRCm38) missense probably damaging 1.00
X0064:Ttc41 UTSW 10 86,729,797 (GRCm38) missense probably benign 0.01
Posted On 2014-01-21