Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL00694:Adgrl4'

10470

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Adgrl4

Ensembl Gene

ENSMUSG00000039167

Gene Name

adhesion G protein-coupled receptor L4

Synonyms

EGF-TM7 receptor, Eltd1, 1110033N21Rik, Etl

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL00694

Quality Score

Status

Chromosome

Chromosomal Location

151143519-151250718 bp(+) (GRCm39)

Type of Mutation

splice site

DNA Base Change (assembly)

T to C at 151145033 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000143744 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000046977] [ENSMUST00000196970]

AlphaFold

Q923X1

Predicted Effect

probably benign
Transcript: ENSMUST00000046977

SMART Domains

Protein: ENSMUSP00000041939
Gene: ENSMUSG00000039167

Domain	Start	End	E-Value	Type
EGF	21	57	9.13e0	SMART
EGF_CA	58	107	4.88e-9	SMART
EGF_CA	108	157	4.88e-9	SMART
Pfam:GAIN	182	390	6.8e-38	PFAM
GPS	414	467	1.25e-17	SMART
Pfam:7tm_2	473	709	2.5e-58	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000141038

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000155652

Predicted Effect

probably benign
Transcript: ENSMUST00000196970

SMART Domains

Protein: ENSMUSP00000143744
Gene: ENSMUSG00000039167

Domain	Start	End	E-Value	Type
signal peptide	1	19	N/A	INTRINSIC
EGF	21	57	4.5e-2	SMART
EGF_CA	58	107	2.5e-11	SMART

Coding Region Coverage

Validation Efficiency

MGI Phenotype

PHENOTYPE: For a targeted mutation, no significant differences were detected between homozygous mice and controls in a high-throughput screen. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 25 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Aqr	A	T	2: 113,982,006 (GRCm39)	D259E	probably damaging	Het
Arl14ep	A	T	2: 106,797,537 (GRCm39)	F153L	probably damaging	Het
Asb15	G	T	6: 24,570,663 (GRCm39)	R547L	possibly damaging	Het
Chd8	A	C	14: 52,455,427 (GRCm39)	V1020G	probably damaging	Het
Coq2	C	T	5: 100,803,180 (GRCm39)	S370N	probably benign	Het
Crebl2	T	A	6: 134,826,158 (GRCm39)	S36R	probably damaging	Het
Cyp2c29	A	T	19: 39,310,079 (GRCm39)	T263S	possibly damaging	Het
Edem1	T	C	6: 108,818,562 (GRCm39)	I190T	possibly damaging	Het
Fbn2	T	G	18: 58,170,881 (GRCm39)	E2170A	possibly damaging	Het
Gak	T	G	5: 108,761,500 (GRCm39)	*129C	probably null	Het
Hc	T	C	2: 34,881,641 (GRCm39)	I1436V	probably benign	Het
Kmt2c	A	T	5: 25,498,159 (GRCm39)	F534I	probably damaging	Het
Mfhas1	G	A	8: 36,057,925 (GRCm39)	R800Q	probably benign	Het
Npat	A	G	9: 53,474,817 (GRCm39)	T870A	probably benign	Het
Pde8a	T	C	7: 80,956,456 (GRCm39)	V285A	possibly damaging	Het
Potegl	A	T	2: 23,120,180 (GRCm39)	Q192L	probably damaging	Het
Pramel28	G	T	4: 143,692,392 (GRCm39)	P203Q	possibly damaging	Het
Slc25a26	T	A	6: 94,511,204 (GRCm39)	I127N	probably damaging	Het
Spag1	A	T	15: 36,227,317 (GRCm39)	E658V	possibly damaging	Het
St3gal2	A	T	8: 111,696,213 (GRCm39)	H266L	probably damaging	Het
Sult6b2	A	G	6: 142,736,015 (GRCm39)	I193T	possibly damaging	Het
Tas2r120	T	C	6: 132,634,238 (GRCm39)	F107L	probably benign	Het
Thoc1	A	G	18: 9,989,744 (GRCm39)	D475G	possibly damaging	Het
Tpo	T	A	12: 30,155,993 (GRCm39)	R169S	probably damaging	Het
Zhx2	A	G	15: 57,685,156 (GRCm39)	N175S	probably benign	Het

Other mutations in Adgrl4

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00488:Adgrl4	APN	3	151,248,478 (GRCm39)	missense	probably damaging	1.00
IGL01143:Adgrl4	APN	3	151,205,866 (GRCm39)	splice site	probably null
IGL01359:Adgrl4	APN	3	151,248,923 (GRCm39)	missense	probably damaging	1.00
IGL01947:Adgrl4	APN	3	151,216,428 (GRCm39)	critical splice donor site	probably null
IGL02149:Adgrl4	APN	3	151,205,991 (GRCm39)	missense	possibly damaging	0.95
IGL02324:Adgrl4	APN	3	151,203,511 (GRCm39)	missense	probably damaging	1.00
IGL02562:Adgrl4	APN	3	151,144,949 (GRCm39)	missense	probably damaging	1.00
IGL02644:Adgrl4	APN	3	151,198,007 (GRCm39)	missense	probably benign	0.00
trivial	UTSW	3	151,223,247 (GRCm39)	missense	probably benign	0.07
R0077:Adgrl4	UTSW	3	151,223,418 (GRCm39)	missense	probably damaging	1.00
R0116:Adgrl4	UTSW	3	151,223,247 (GRCm39)	missense	probably benign	0.07
R0331:Adgrl4	UTSW	3	151,203,577 (GRCm39)	missense	probably benign	0.00
R0601:Adgrl4	UTSW	3	151,204,066 (GRCm39)	splice site	probably benign
R0613:Adgrl4	UTSW	3	151,248,859 (GRCm39)	splice site	probably benign
R1293:Adgrl4	UTSW	3	151,213,081 (GRCm39)	missense	probably benign	0.00
R1463:Adgrl4	UTSW	3	151,216,233 (GRCm39)	missense	probably damaging	0.98
R1697:Adgrl4	UTSW	3	151,223,248 (GRCm39)	missense	probably damaging	1.00
R1731:Adgrl4	UTSW	3	151,246,623 (GRCm39)	missense	possibly damaging	0.64
R1765:Adgrl4	UTSW	3	151,248,872 (GRCm39)	missense	probably damaging	1.00
R1782:Adgrl4	UTSW	3	151,248,442 (GRCm39)	nonsense	probably null
R1888:Adgrl4	UTSW	3	151,144,914 (GRCm39)	missense	probably benign	0.11
R1888:Adgrl4	UTSW	3	151,144,914 (GRCm39)	missense	probably benign	0.11
R1957:Adgrl4	UTSW	3	151,216,416 (GRCm39)	missense	possibly damaging	0.94
R2128:Adgrl4	UTSW	3	151,205,838 (GRCm39)	missense	probably benign	0.00
R2180:Adgrl4	UTSW	3	151,205,779 (GRCm39)	missense	probably damaging	0.96
R2238:Adgrl4	UTSW	3	151,205,779 (GRCm39)	missense	probably damaging	0.96
R2474:Adgrl4	UTSW	3	151,248,361 (GRCm39)	missense	probably benign	0.01
R2697:Adgrl4	UTSW	3	151,216,260 (GRCm39)	missense	probably damaging	1.00
R3835:Adgrl4	UTSW	3	151,216,254 (GRCm39)	missense	probably damaging	1.00
R4499:Adgrl4	UTSW	3	151,216,422 (GRCm39)	missense	possibly damaging	0.81
R4640:Adgrl4	UTSW	3	151,205,947 (GRCm39)	unclassified	probably benign
R4747:Adgrl4	UTSW	3	151,213,077 (GRCm39)	missense	probably benign	0.01
R5428:Adgrl4	UTSW	3	151,248,323 (GRCm39)	missense	probably damaging	1.00
R5510:Adgrl4	UTSW	3	151,203,467 (GRCm39)	missense	possibly damaging	0.89
R5717:Adgrl4	UTSW	3	151,197,971 (GRCm39)	missense	probably benign	0.01
R6106:Adgrl4	UTSW	3	151,246,622 (GRCm39)	missense	possibly damaging	0.67
R6343:Adgrl4	UTSW	3	151,223,443 (GRCm39)	missense	probably damaging	1.00
R6419:Adgrl4	UTSW	3	151,144,953 (GRCm39)	missense	probably damaging	1.00
R6468:Adgrl4	UTSW	3	151,198,012 (GRCm39)	missense	probably benign
R6636:Adgrl4	UTSW	3	151,223,410 (GRCm39)	nonsense	probably null
R6637:Adgrl4	UTSW	3	151,223,410 (GRCm39)	nonsense	probably null
R6687:Adgrl4	UTSW	3	151,248,392 (GRCm39)	missense	probably benign	0.00
R6856:Adgrl4	UTSW	3	151,205,755 (GRCm39)	missense	probably benign	0.00
R6887:Adgrl4	UTSW	3	151,248,370 (GRCm39)	missense	possibly damaging	0.46
R7041:Adgrl4	UTSW	3	151,144,959 (GRCm39)	missense	probably benign	0.00
R7527:Adgrl4	UTSW	3	151,144,887 (GRCm39)	missense	probably benign	0.08
R7597:Adgrl4	UTSW	3	151,248,895 (GRCm39)	missense	probably damaging	1.00
R7751:Adgrl4	UTSW	3	151,197,946 (GRCm39)	missense	probably damaging	0.99
R8556:Adgrl4	UTSW	3	151,216,302 (GRCm39)	missense	probably damaging	0.98
R8696:Adgrl4	UTSW	3	151,248,344 (GRCm39)	missense	probably damaging	1.00
R8698:Adgrl4	UTSW	3	151,203,512 (GRCm39)	missense	probably damaging	1.00
R8795:Adgrl4	UTSW	3	151,216,416 (GRCm39)	missense	probably benign	0.03
R9226:Adgrl4	UTSW	3	151,198,064 (GRCm39)	critical splice donor site	probably null
R9655:Adgrl4	UTSW	3	151,248,450 (GRCm39)	missense	probably damaging	0.96
R9755:Adgrl4	UTSW	3	151,216,418 (GRCm39)	missense	probably benign	0.01
R9767:Adgrl4	UTSW	3	151,207,394 (GRCm39)	missense	probably benign	0.16
R9784:Adgrl4	UTSW	3	151,214,948 (GRCm39)	missense	probably damaging	1.00
X0053:Adgrl4	UTSW	3	151,203,470 (GRCm39)	missense	probably damaging	1.00
Z1088:Adgrl4	UTSW	3	151,205,812 (GRCm39)	missense	probably benign	0.00

Posted On

2012-12-06